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Chemistry and pharmacology of the citrus bioflavonoid hesperidin
Abstract
Hesperidin, a bioflavonoid, is an abundant and inexpensive by‐product of Citrus cultivation. A deficiency of this substance in the diet has been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night leg cramps. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Both hesperidin and its aglycone hesperetin have been reported to possess a wide range of pharmacological properties. This paper reviews various aspects of hesperidin and its related compounds, including their occurrence, physical and chemical properties, analysis, pharmacokinetics, safety and toxicity and the marketed products available. A special emphasis has been laid on the pharmacological properties and medicinal uses of these compounds. Copyright © 2001 John Wiley & Sons, Ltd.
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Cited by
Converting citrus wastes into value-added products: Economic and environmently friendly approaches
Sharma, K., Mahato, N., Cho, M. H., & Lee, Y. R. (2017) · Nutrition · doi:10.1016/j.nut.2016.09.006 · Cited by 617
Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits
Bellavite, P., & Donzelli, A. (2020) · Antioxidants · doi:10.3390/antiox9080742 · Cited by 207
Landberg, R., Sun, Q., Rimm, E. B., Cassidy, A., Scalbert, A., Mantzoros, C. S., Hu, F. B., & van Dam, R. M. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.133843 · Cited by 121
Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms
Li, R., Li, J., Cai, L., Hu, C.-M., & Zhang, L. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.2.0011 · Cited by 84
Cincin, Z. B., Kiran, B., Baran, Y., & Cakmakoglu, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.020 · Cited by 56
Metadata
- Authors
- Garg, A., Garg, S., Zaneveld, L. J. D., & Singla, A. K.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2001-10-23
- Volume
- 15
- Issue
- 8
- Pages
- 655-669
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1965119043
- Cited by
- 856
- References
- 0
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garg, A., Garg, S., Zaneveld, L. J. D., & Singla, A. K. (2001). Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytotherapy Research. https://doi.org/10.1002/ptr.1074
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