Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women
Open accessAbstract
Flavonoids show antiinflammatory effects in vitro and human intervention studies have suggested beneficial effects of flavonoid-rich foods on biomarkers of inflammation and endothelial function. In the present study, we assessed the relationship between flavonoid intake and biomarkers of inflammation and endothelial dysfunction in a cross-sectional study of participants from the Nurses' Health Study cohort. Intake of 6 flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and polymeric flavonoids) was assessed using a FFQ administered in 1990. Also, the main food sources of these flavonoids were examined. Blood samples were collected in 1989-1990 and plasma C-reactive protein (CRP), IL-6, IL-18, soluble tumor necrosis factor receptor-2 (sTNF-R2), soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 1194-1598 women. The multivariate-adjusted geometric mean of plasma IL-8 were lower for women in the highest intake quintile of flavones, flavanones, and total flavonoids compared with those in the lowest quintiles by 9% (Q1: 264 ng/L, Q5: 241 ng/L; P-trend = 0.019), 11% (Q1: 273 ng/L, Q5: 244 ng/L; P-trend = 0.011), and 8% (Q1: 276 ng/L, Q5: 55 ng/L; P-trend = 0.034), respectively. The multivariate-adjusted geometric mean for women in the highest intake quintile of flavonol compared with those in the lowest quintile was 4% lower for sVCAM-1 (Q1: 578 μg/L, Q5: 557 μg/L; P-trend = 0.012). Among flavonoid-rich foods, higher intake of grapefruit was significantly associated with lower concentrations of CRP and sTNF-R2. In summary, higher intakes of selected flavonoid subclasses were associated with modestly lower concentrations of inflammatory biomarkers. In particular, flavonoids typically found in citrus fruits were modestly associated with lower plasma IL-18 concentrations.
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Adipokine secretion profiles differ between subcutaneous and abdominal adipose tissues.
“In addition, the profile of adipokines produced is dissimilar between the subcutaneous and abdominal adipose tissues.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [57]
Leptin is preferentially expressed and secreted by subcutaneous adipose tissue, while adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogene, CCL5 and MIP-1b are expressed more in abdominal fat.
“Thus, leptin is preferentially expressed and secreted by subcutaneous adipose tissue (52) , while the expression of adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogena, CCL5 and MIP-1b is higher in abdominal fat.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [57]
IL-6 and TNF-a appear to be synthesised equally by different adipose tissue sites.
“In contrast to such distributions, there are reports that IL-6 and TNF-a seem to be equally synthesised by the different sites (28,36,53 -59) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [57]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
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- Authors
- Landberg, R., Sun, Q., Rimm, E. B., Cassidy, A., Scalbert, A., Mantzoros, C. S., Hu, F. B., & van Dam, R. M.
- Affiliations
- Swedish University of Agricultural Sciences (SE)
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Unité de Nutrition Humaine (FR)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Landberg, Rikard
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 141
- Issue
- 4
- Pages
- 618-625
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC3057665
- OpenAlex
- W2151975547
- Cited by
- 121
- References
- 63
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 14 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 11 · 2014: 10 · 2013: 14 · 2012: 15
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- National University of Singapore (submittedVersion)
- HAL (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K99HL098459)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082486)
- National Institute of Dental and Craniofacial Research (R01 DE082486)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- dietary flavonoids, inflammatory markers, endothelial dysfunction, flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, C-reactive protein, interleukin-6, IL-18, soluble tumor necrosis factor receptor 2, soluble VCAM-1, E-selectin, interleukin-8, grapefruit, citrus fruit, women's health, flavonoid-rich foods
- MeSH terms
- Adult, Aged, C-Reactive Protein, Female, Flavonoids, Humans, Inflammation, Middle Aged, Biomarkers, Interleukin-18, Endothelial Cells, Receptors, Tumor Necrosis Factor, Type II
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