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Cited by 365Nigella sativa pharmacological applicationsMedicinal Plant ResearchEssential Oils and Antimicrobial Activity

Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug

Hajhashemi, Valiollah, Ghannadi, Alireza, Jafarabadi, Hadi·2004·Phytotherapy Research
DOI 10.1002/ptr.1390
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Abstract

The steam-distilled essential oil of Iranian black cumin seed (Nigella sativa L.) was investigated for its composition and analgesic and antiinflammatory properties. After oil analysis by GC/MS, 20 compounds were identified in the oil, obtained in 0.4% (v/w) yield. Among them, para-cymene (37.3%) and thymoquinone (13.7%) were the major components. Acetic acid-induced writhing, formalin and light tail flick tests were used for assessment of analgesic activity. Antiinflammatory activity was evaluated using carrageenan-induced paw oedema in rats and croton oil-induced ear oedema in mice. Black cumin seed essential oil (BCSEO) was found to produce a significant analgesic effect in acetic acid-induced writhing, formalin and light tail flick tests. Naloxone, an opioid antagonist, could not reverse the analgesic effect observed in the formalin test. Although oral administration of BCSEO at doses of 100, 200 and 400 micro L/kg did not exert a significant antiinflammatory effect in the carrageenan test, i.p. injection of the same doses significantly (p < 0.001) inhibited carrageenan-induced paw oedema. BCSEO at doses of 10 and 20 micro L/ear could also reduce croton oil-induced oedema. It seems that mechanism(s) other than opioid receptors is (are) involved in the analgesic effect of BCSEO since naloxone could not reverse this effect. Both systemic and local administration of BCSEO showed antiinflammatory activity. Thymoquinone, as one of the major components of BCSEO, probably has an important role in these pharmacological effects.

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  • Carrageenan-induced mouse paw oedema is frequently used to determine anti-inflammatory activity of plant extracts and essential oils.

    “Carrageenan-induced mouse paw oedema is frequently used to determine the anti-inflammatory activity of diverse bioactive compounds such as plant extracts and essential oils [87,88,89,90,91,92,93,94,95].”

    From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [88]

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Authors
Hajhashemi, V., Ghannadi, A., & Jafarabadi, H.
Affiliations
Isfahan University of Medical Sciences (IR)
Corresponding author
Hajhashemi, Valiollah
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2004-03
Volume
18
Issue
3
Pages
195-199
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.1390
OpenAlex
W2035201015
Cited by
365
References
28
Citations by year
2026: 4 · 2025: 5 · 2024: 12 · 2023: 18 · 2022: 22 · 2021: 33 · 2020: 28 · 2019: 16 · 2018: 15 · 2017: 18 · 2016: 23 · 2015: 24 · 2014: 26 · 2013: 20 · 2012: 15
FWCI
17.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 45 d)
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Research Council of the Isfahan University of Medical Sciences, Isfahan, Iran (80239)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
Nigella sativa, thymoquinone, p-cymene, analgesic activity, anti-inflammatory activity, carrageenan-induced paw edema, formalin test, acetic acid-induced writhing, naloxone, essential oil composition
MeSH terms
Administration, Oral, Analgesics, Animals, Anti-Inflammatory Agents, Non-Steroidal, Carrageenan, Croton Oil, Dose-Response Relationship, Drug, Edema, Formaldehyde, Male, Phytotherapy, Pain, Pain Measurement, Plant Oils, Seeds, Acetic Acid, Nigella sativa, Mice

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