Crocus sativus L. in the treatment of mild to moderate depression: a double‐blind, randomized and placebo‐controlled trial
Akhondzadeh, Shahin, Tahmacebi‐Pour, Najaf, Noorbala, Ahamad‐Ali, Amini, Homayoun, Fallah‐Pour, Hassan, Jamshidi, Amir‐Hossein, Khani, Mousa·2005·Phytotherapy Research
DOI 10.1002/ptr.1647
Cited by (298)
Items 201–298 of 298
- Saffron and Neurological DisordersSaeed Samarghandian, Tahereh Farkhondeh · 2020 · Elsevier eBooks
- The Effect of Krocina™ on Decreasing Substance User Withdrawal Syndrome, Craving, Depression and Stress: A Double-Blind Randomized Parallel Clinical TrialHamid Jomehpour, Shahrokh Aghayan, Ahmad Khosravi, Fahimeh Afzaljavan · 2022 · Substance Use & Misuse
- Saffron (Crocus sativus) and its constituents for pain management: A review of current evidenceAli Mohammad Pourbagher‐Shahri, Fatemeh Forouzanfar · 2023 · Phytotherapy Research
- Contact Dermatitis in Saffron Workers: Clinical Profile and Identification of Contact Sensitizers in a Saffron-Cultivating Area of Kashmir Valley of North IndiaIffat Hassan, Afifa S. Kamili, Farhan Rasool, F.A. Nehvi, Parvaiz Anwar Rather, Salwee Yasmin, Rafiq Ahmed Pampori, Yasmeen Jabeen, Atiya Yaseen, Safia Bashir et al. · 2015 · Dermatitis
- Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the EvidenceAhmad Shamabadi, Shahin Akhondzadeh · 2021 · Archives of Iranian Medicine
- Exploring Saffron's Therapeutic Potential: Insights on Phytochemistry, Bioactivity, and Clinical ImplicationsDebasis Sen, Sunny Rathee, Vishal Pandey, Sanjay Jain · 2024 · Current Pharmaceutical Design
- Mechanisms of action of herbal antidepressantsMahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh · 2021 · Elsevier eBooks
- Problems in the Descriptions of the Psychiatric Inclusion and Exclusion Criteria in Publications of Antidepressant Efficacy Trials: A Qualitative Review and Recommendations for Improved ClarityMark Zimmerman, Matthew D. Multach, Emily K. Walsh, Lia K. Rosenstein, Douglas Gazarian, Heather Clark · 2016 · CNS Drugs
- Antidepressant Effect of Crocus sativus: an Evidence Based ReviewMaryam Kamalipour, A H Jamshidi, Shahin Akhondzadeh · 2010 · DOAJ (DOAJ: Directory of Open Access Journals)
- Use of saffron as a functional food and saffron nutraceuticalsCeleste De Monte, Stefania Cesa · 2020 · Elsevier eBooks
- Current Research on Complementary and Alternative Medicine (CAM) in the Treatment of Major Depressive Disorder: An Evidence-Based ReviewVladimir Trkulja, Hrvoje Barić · 2021 · Advances in experimental medicine and biology
- Anticonvulsant effects of hydroalcoholic extract of Melissa officinalis on pentylenetetrazole (PTZ) model of convulsion in miceReza Ebrahimi Hariry · 2011 · Journal of Medicinal Plants Research
- Novel Insights into Dietary Bioactive Compounds and Major Depressive Disorders: Evidence from Animal Studies and Future PerspectivesChwan‐Li Shen, Taha Hassan, Peyton Presto, Daniel Payberah, Rodan Devega, Sarah Mallard Wakefield, Dale M. Dunn, Volker Neugebauer · 2025 · Journal of Nutrition
- Understanding the research landscape of over-the-counter herbal products, dietary supplements, and medications evaluated for depressive symptoms in adults: a scoping reviewRachael Frost, Aiman Zamri, Silvy Mathew, Adriana Salame, Cini Bhanu, Sukvinder Kaur Bhamra, Juan Carlos Bazo‐Alvarez, Michael Heinrich, Kate R Walters · 2025 · Frontiers in Pharmacology
- Crocus sativus L. (saffron) extract antioxidant potential and use in agingSaeed Samarghandian, Tahereh Farkhondeh, Tayebeh Zeinali · 2020 · Elsevier eBooks
- Natural Products in the Clinical Management of Metabolic SyndromeOzra Tabatabaei‐Malazy, Narges Lavari, Mohammad Reza Abdollahi · 2024 · Handbook of experimental pharmacology
- Effect of combination of honey, saffron (Crocus sativus L.) and sedge (Cyperus rotundus L.) on cognitive dysfunction in patients with Alzheimer's diseaseNahid Jivad, Nadereh Zare-Hassanabadi, Mahmoud Azizi · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
- Crocus sativus Linn - A Potential Source for Diverse Therapeutic ApplicationsM. Malathi, D. Ramya Devi, B.N. Vedha Hari · 2014
- Advances in bioactive compounds from Crocus sativus (saffron): Structure, bioactivity and biotechnologyDevendra Kumar Pandey, Samapika Nandy, Anuradha Mukherjee, Abhijit Dey · 2020 · Studies in natural products chemistry
- Saffron Safety in Humans: Lessons from the Animal and Clinical StudiesLymperopoulou CD, Fotini N. Lamari · 2015 · Medicinal & Aromatic Plants
- Saffron (Crocus sativus)Jean M. Bokelmann · 2021 · Elsevier eBooks
- Mood Disorders in YouthKirti Saxena, Sherin R. Kurian, Reena R. Kumar, Lawrence Eugene Arnold, Deborah Risher Simkin · 2023 · Child and Adolescent Psychiatric Clinics of North America
- Antidepressant and antianxiety properties of saffronSeyed Ahmad Mohajeri, Samaneh Sepahi, Adel Ghorani‐Azam · 2020 · Elsevier eBooks
- Antidepressant activity of Crocus sativus L. and its main constituents: A reviewBibi Marjan Razavi, Azar Hosseini, Hossein Hosseinzadeh · 2021 · Elsevier eBooks
- Crocus sativusT. K. Lim · 2014 · Springer eBooks
- Herbal Medicines in the Treatment of Depression and AnxietyMaryam Kamalipour, SH Akhondzadeh, Sh Rezazadeh · 2008 · DOAJ (DOAJ: Directory of Open Access Journals)
- Effect of saffron on depression, anxiety and mood disorder: a GRADE assessed systematic review and meta-analysis of 34 randomized controlled trialsRoya Mahmoudi, Mohsen Mohammadi Sartang, Karo Servatyari, Nastaran Rafieipour · 2026 · Nutritional Neuroscience
- The Influence of Spermidine and Biofertilizer Application on the Growth, Yield and Some Active Constituents of Saffron Plant (Crocus sativus L.)Saad Ali Ihsan, Maher H. S. Al-Mohammad, Sabah N. Al-Thamir · 2014 · Journals & Books Hosting (International Knowledge Sharing Platform)
- Application of Somatic Embryogenesis to Secondary Metabolite-Producing PlantsFelipe Vázquez‐Flota, Miriam Monforte‐González, María de Lourdes Miranda‐Ham · 2016 · Springer eBooks
- Saffron: A Therapeutic and Prophylactic Nutrition for Human PopulationM. H. Khan, Bashir Ahmad Alie, Asif M. Iqbal Qureshi, G. H. Mir, Niyaz A. Dar, Shahid Qayoom, Tauseef Ali, Shabir Ahmad Dar, Ajaz Ahmad Lone, Z. A. Dar et al. · 2021 · Springer eBooks
- The Effect of Crocin and its Mechanism of Action on Chronic Pain Induced by Spinal Cord Contusion in a Rat ModelMasoume Karami, Bathaie Seyede Zahra, Tiraihi Taqi, Habibi Rezaie Mehran, Arab Kheradmand Jalil, Faghihzadeh Soghrat · 2013
- Antinociceptive Effects of Pomegranate (Punica granatum L.) Juice and Seed Extracts on Acute Corneal Pain in MiceZahra Malek, Shirin Mansoori Dara, Mahsa Hadipour Jahromy · 2014 · World Journal of Neuroscience
- Evidence Based Herbal Medicine and Mental HealthReza Hajiaghaee, Shahin Akhondzadeh · 2012 · DOAJ (DOAJ: Directory of Open Access Journals)
- Exploring the neurofunctional potential of saffron bioactives: from mood-related behavioral modulation to brain access of safranalCamille Monchaux de Oliveira, Adeline Vignault, Alexandrine Guille, Sylvie Vancassel, Lucile Capuron, Line Pourtau, Nathalie Castanon · 2026 · Food & Function
- AN OVERVIEW OF SOME HERBAL ANTIDEPRESSANT PLANTSTANMAYI PATIL, Mohan Kale, Rutuja G. Kumbhar, VISHAL SHARAD BODKE, KOMAL CHAUDHARI · 2024 · International Journal of Current Pharmaceutical Research
- A Cluster-wise Linear Regression Model to Investigate the Effect of Demographical and Clinical Variables on the Average Depression ScoreZahra Zamaninasab, Hamid Najafipour, Moghaddameh Mirzaee, Abbas Bahrampour · 2022 · Medical Journal of the Islamic Republic of Iran
- Histopathological and biomedical parameters determination in the protective effect of crocin on hepatotoxicity induced by methotrexate in ratsCyrus Jalili, Amir Abdolmaleki, Shiva Roshankhah, Mohammad Reza Salahshoor · 2020 · Journal of Herbmed Pharmacology · Retracted
- Anxiolytics of natural origin I. Originally occurring plants and plants cultivated in the Czech RepublicZdeňka Navrátilová · 2012 · Kontakt
- Integrative and Complementary Medicine in PsychiatryJerome J. Sarris, Patricia L. Gerbarg, Richard P. Brown, Philip R. Muskin · 2015
- Plantas medicinais com potencial para tratamento de transtornos de ansiedade e depressão: uma revisão integrativaTânea Maria Bisognin Garlet, Bettina Monika Ruppelt · 2024 · Revista Fitos
- Saffron as a Retinal Neuroprotectant: A Narrative Review of Preclinical Studies and Clinical ResultsMaria Anna Maggi, Rocco Mastromartino, Marco Piccardi, Angelo Maria Minnella, Dario Marangoni, Stefano Di Marco, Benedetto Falsini, Silvia Bisti · 2026 · Antioxidants
- Corm size and planting density affect the yield and longevity of saffron (Crocus sativus L.)Parthenopi Ralli, Georgios C. Menexes, Christos A. Dordas · 2024 · Notulae Botanicae Horti Agrobotanici Cluj-Napoca
- A systematic review on the use of phytotherapy in managing clinical depressionSutude Fazilat, Fateme Tahmasbi, Mohammadreza Mirzaei, Sarvin Sanaie, Zahra Yousefi, Solmaz Asnaashari, Shadi Yaqoubi, Ahad Banagozar Mohammadi, Mostafa Araj‐Khodaei · 2024 · Bioimpacts
- Optimizing Saffron Flowering and Yield as Affected by Vernalization and Corm Size of Crocus Sativus L.S. Shah, Masood Ahmad, Hamza Ali, Naeem Ahmad, Mehdi Raza, Asim Hassan, Sadaf Hussain, Shahana Jabin, Sumbal Ayaz, Midrar Ullah et al. · 2024 · Indus journal of bioscience research.
- Herbal Medicine in the Treatment of Premenstrual SyndromesLadan Kashani, Reza Hajiaghaee, Shahin Akhondzadeh · 2011 · DOAJ (DOAJ: Directory of Open Access Journals)
- Pharmacological Importance of Crocus sativus ApocarotenoidsShoib Ahmad Baba, Nasheeman Ashraf · 2016 · SpringerBriefs in plant science
- VALORISATION OF SAFFRON (CROCUS SATIVUS)Georges Betti, Mathias Schmidt · 2007 · Acta Horticulturae
- Crocus sativus L. (Iridaceae)Shahid Akbar · 2020 · Springer eBooks
- Therapeutic Effects of Citrus aurantium Components on Psychological States: A Systematic ReviewFarkhondeh Aboualsoltani, Parvin Bastani, Laleh Khodaie, Seyyed Mohammad Bagher Fazljou · 2020 · DOAJ (DOAJ: Directory of Open Access Journals)
- A REVIEW OF MEDICINAL PLANTS POSSESSING ANTIDEPRESSANT POTENTIALAshwani K. Dhingra, Bhawna Chopra, Rameshwar Dass, Suchita Mittal · 2016 · INDIAN DRUGS
- Probing the Mystery of the Use of Saffron in Medieval NunneriesVolker Schier · 2010 · The Senses and Society
- Treatments for Comorbid Anxiety and Mood DisordersJerome J. Sarris, David Mischoulon · 2016 · Springer eBooks
- SaffronYousef Rasmi, Elihud Salazar, Ena Gupta, Behrokh Daeihassani, Martín Calderón‐Juárez · 2022 · Wiley eBooks
- Memory-boosting fruits and foods for elderlyRajeshwar Kamal Kant Arya, Meena Kausar, Dheeraj Bisht, Raj Kumar Keservani, Amit Kumar · 2024 · Elsevier eBooks
- Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysisMohammad Mehdi Mohammadi, Zohreh Karimi · 2025 · Korean Journal of Family Medicine
- Therapeutic effects of Crocus sativus: An overview of systematic reviewsHojjat Rouhi-Boroujeni, Sara Kiani · 2016 · DOAJ (DOAJ: Directory of Open Access Journals)
- Herbal Medicine for Women\'s HealthLadan Kashani, M.-R. Nikbakhat, Shahin Akhondzadeh · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
- Alternative Therapieoptionen bei erektiler DysfunktionJulian Marcon, Christian Georg Stief, Matthias Trottmann · 2016 · Uro-News
- ApocarotenoidsMadiha Ilyas, Faraz Ali Rana, Muhammad Riaz · 2021 · Springer eBooks
- Integrative and Complementary Medicine in PsychiatryJerome J. Sarris, Patricia L. Gerbarg, Richard P. Brown, Philip R. Muskin · 2023 · Springer eBooks
- Integrative and Complementary Medicine in PsychiatryJerome J. Sarris, Patricia L. Gerbarg, Richard P. Brown, Philip R. Muskin · 2024 · Springer eBooks
- Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild‐to‐Moderate Anxiety During the COVID‐19 LockdownCristina Pages-García, M. Almagro, Jorge Ruíz-Moreno, Roser De-Castellar · 2024 · Depression and Anxiety
- Comparison of Salivary Opiorphin in Burning Mouth Syndrome and Healthy Subjects and Its Correlation With Psychiatric DisordersZohreh Dalirsani, Maryam Amirchaghmaghi, M Najafi Semnani, Mahdi Talebi, Seyed Isaac Hashemy, Mohammad Taghi Shakeri, Ava Taghizadeh · 2024 · Clinical and Experimental Dental Research
- Clinical Perspective on The Effects of Crocus sativus in Depression and Attention Deficit Hyperactivity Disorder and Sleep QualityDidem Deliorman Orhan · 2025 · Pharmedicine journal.
- Efficacy of Saffron ( Crocus sativus L.) and Its Constituents on Breast Cancer, a Systematic Review of Preclinical Studies and Potential Therapeutic MechanismsFatemeh Sadat Hasheminasab, Maryam Azimi · 2025 · Integrative Cancer Therapies
- Protective effects of Saffron hydroalcoholic extract against renal tissue damages induced by ischemia-reperfusion in ratsHoushang Najafi, Leila Mahmoudzadeh, Darioush Shakibae · 2014 · DOAJ (DOAJ: Directory of Open Access Journals)
- Passionflower and Sage for Mental HealthReza Hajiaghaee, S Akhondzadeh · 2013 · DOAJ (DOAJ: Directory of Open Access Journals)
- DepressionCraig Schneider, Theodore Wissink · 2017 · Elsevier eBooks
- Herbal Medicine and Women’s Mental HealthLadan Kashani, Shahin Akhondzadeh · 2009 · DOAJ (DOAJ: Directory of Open Access Journals)
- Saffron a Prototype Example for Evidence Based Herbal MedicineReza Hajiaghaee, Mahmoud Reza Heidari, Shahin Akhondzadeh · 2013 · DOAJ (DOAJ: Directory of Open Access Journals)
- Effectiveness of Medicinal Plants Extract Combination on Sexual and Psychological Performance in Patients with SchizophreniaRezaei Omid, Majedi Elmira, Asghar Dadkhah, Masafi Saideh, Rooshenas Fatemeh · 2014
- Evidence Based Medicine: Clinical TrialsLadan Kashani, R Hajaghaee, Shahin Akhondzadeh · 2014 · DOAJ (DOAJ: Directory of Open Access Journals)
- 4BGGSPO$SPDVTTBUJWVT-BOENBKPSE FQSFTTJWF EJTPSEFSBNFUB BOBMZTJTPGSBO EPNJ(FEDMJOJDBM USJBMTHeather Ann Hausenblas, Debbie Saha, Pamela J. Dubyak, Stephen Douglas Anton · 2013
- Botanicals for Depression: Rhodiola, St. John’s Wort, Curcumin, and SaffronJudith Pentz · 2015 · CRC Press eBooks
- Mental health and complementary and alternative medicineJerome J. Sarris, James Lake · 2012
- Both sides of the saffron’s coinMuhammad Torequl Islam · 2017 · International Journal of Medicine
- Alternative Therapieoptionen bei erektiler DysfunktionJulian Marcon, Christian Georg Stief, Matthias Trottmann · 2017 · Journal für Urologie und Urogynäkologie/Österreich
- Traditional Medicines for Mental HealthSmıta Sıngh, Anup Kumar Singh, Abhai Kumar, Rameshwar Nath Chaurasia · 2020 · CRC Press eBooks
- Depression2011 · Elsevier eBooks
- Alternative Therapieoptionen bei erektiler DysfunktionJulian Marcon, Christian Georg Stief, Matthias Trottmann · 2017 · Journal für Urologie und Urogynäkologie/Österreich
- An Assessment of Neurological and Psychological Disorders and Their Herbal Therapeutic TreatmentNitesh Kumar, Pratibha Pratibha, Ruchika Devi, Harinder Singh Banyal, Vineeta Yadav, Neeraj Kumari Chauhan, Aviral Goswami, Pankaj Thakur, Sunil Kumar Sharma · 2024 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- Spices as CosmeceuticalsB. Chempakam, P. N. Ravindran · 2023 · Springer eBooks
- Indian SaffronBashir Ahmad Alie, M. H. Khan, Niyaz A. Dar, F.A. Nehvi, G. H. Mir, Asif M. Iqbal Qureshi, Mehraj uddin Sofi, M. T. Ali · 2023 · Springer eBooks
- Effectiveness of saffron in the treatment of mild to moderate Alzheimer’s disease with ADAS-cog scoreVenkata Sunanda Bhumireddy Papireddygari, Rammohan Bondha, Abhay Kumar John · 2024 · International Journal of Health Sciences
- Effect of Phosphorus and Planting Distance on Corm Production of Saffron (Crocus sativus)Masood Sayeed, Gul Ahmad Zahiryan, Rohullah Zahiryan, Najibullah Mujadadi · 2023 · Nangarhar University international journal of biosciences.
- From Mood to Memory: Unlocking Saffron’s Potential in Brain HealthTarlan Kehtari, Diego Cardenas Tovar, Dustin Epstein, Patricia Junquera · 2025 · Cureus
- Herbal Products for Depression in Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta‐AnalysisRui‐Feng Yang, You Wu, Lindong Zhang, Lili Wu, Lingling Qin, Tonghua Liu · 2025 · Phytotherapy Research
- The impacts of Crocin on serum cytokines concentrations in participants with metabolic syndrome: a double-blind randomized clinical trial studyRazie Rezaiee, Hamideh Ghazizadeh, Susan Darroudi, Roshanak Ghaffarian Zirak, Mohadese Rohban, Marziyeh Eidi, Irandokht Nikbakht‐Jam, Ali Asghar Mahmoudi, Farzin Hadizadeh, Malihe Aghasizadeh et al. · 2025 · Scientific Reports
- Vergleich der Wirkung und Anwendung von Arzneipflanzen, die in der ayurvedischen und der westlichen Medizin verwendet werden oder verfügbar sindWolfgang Schachinger, Michael Wink, Hermann Philipp Theodor Ammon, Ernst Schrott · 2026 · Springer eBooks
- Targeting pathological chemokines in CVD: the role of saffron on CCL2 and CXCL8Yousef Baghcheghi, Ahmad Golkar, Ali Moghbeli, Mahdiyeh Hedayati‐Moghadam · 2026 · Molecular Biology Reports
- The Role of Saffron in the Treatment of Depression: A Literature ReviewLuigi Dimech · 2026 · Cureus
- Current Umbrella Evidence on Nutraceuticals and Herbal Medicine for Depression in Adults: A Scoping ReviewGiorgos Tzigkounakis, Jonathan E. Brown, Konstantinos Georgiadis · 2026 · Journal of Integrative and Complementary Medicine
- Troubles dépressifs et réponse thérapeutique : mécanismes d'action et modulation nutritionnelle par des actifs de safran (Crocus sativus L.).Camille Monchaux de Oliveira · 2021 · theses.fr (ABES)
- Brain–immune mechanisms underpinning the mental effects of Ayurvedic botanical medicinal plants: A narrative review of clinical evidence and neuroimmune pathwaysBernhard Theodor Baune, Mansi M. Patel, Manish V Patel, Shivenarain N. Gupta · 2026 · Brain Behavior and Immunity Integrative
- The SAFE-study: comparative treatment effect, side effect and health evaluation of allopathic versus ayurvedic treatments for major depressive disorder: a naturalistic real-world studyB. Baune, Anusha Prabhakaran, M. Patel, Sarah Elisabeth Fromme Grübel, Jagdish Varma, Manish Patel, Shivenarain N. Gupta · 2026 · Frontiers in Psychiatry
- Ayurvedic Dravya-Based Herbal Products for Cognition, Stress, Sleep, and Psychiatric Symptoms: A Node-Resolved Systematic Review and Meta-AnalysisBernhard Theodor Baune, Mansi M. Patel, Manish V Patel, Shivenarain N. Gupta · 2026 · Journal of Integrative and Complementary Medicine
- Ameliorated potential and possible mechanisms of medicine food homology for depressionChunyan Huo, Qiang Li, Ning Cai, Chao Teng, Jie Kou · 2026 · 3 Biotech
- Neuroprotective potential of natural products in dementia: Mechanisms and clinical evidenceArya Sajeev, T P Reshma, O Shilpa, Anu Joseph · 2026 · Pharmacological Research - Natural Products