Evaluation of antinociceptive and antiinflammatory activities of the essential oil (EO) of Ocimum micranthum Willd. from Northeastern Brazil
Abstract
The EO of Ocimum micranthum was studied for a possible analgesic effect on the acetic acid induced writhing and formalin test in mice and antioedema activities on the carrageenan and dextran induced paw oedema in rats. The EO demonstrated antinociceptive effects, and pretreatment with naloxone did not reverse the antinociception, indicating that the opioid system is not involved. On the other hand, pretreatment with L-arginine (L-arg) reversed the antinociception, suggesting involvement of the nitric oxide (NO) system. The EO did not present an antioedematogenic effect in the carrageenan and dextran models.
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Carrageenan-induced mouse paw oedema is frequently used to determine anti-inflammatory activity of plant extracts and essential oils.
“Carrageenan-induced mouse paw oedema is frequently used to determine the anti-inflammatory activity of diverse bioactive compounds such as plant extracts and essential oils [87,88,89,90,91,92,93,94,95].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [90]
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- Authors
- Lino, C. S., Gomes, P. B., Lucetti, D. L., Diógenes, J. P. L., Sousa, F. C. F., Silva, M. G. V., & Viana, G. S. B.
- Affiliations
- Universidade Federal do Ceará (BR)
- Corresponding author
- Lino, C. S.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2005-08
- Volume
- 19
- Issue
- 8
- Pages
- 708-712
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1996059978
- Cited by
- 25
- References
- 24
- Citations by year
- 2026: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- essential oils, antinociceptive activity, anti-inflammatory activity, acetic acid-induced writhing, formalin test, paw edema, carrageenan, dextran, naloxone, L-arginine, nitric oxide system, opioid system, analgesic effect
- MeSH terms
- Analgesics, Animals, Anti-Inflammatory Agents, Arginine, Brazil, Edema, Female, Male, Phytotherapy, Naloxone, Narcotic Antagonists, Oils, Volatile, Plant Oils, Ocimum, Mice
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