The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Antiviral effects of Glycyrrhiza species
Open accessAbstract
Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus‐induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV‐1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV‐1 with the cell, induction of interferon gamma in T‐cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs. Copyright © 2007 John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,346
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., & Doerr, H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13615-x · Cited by 1,158
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds
Chen, F., Chan, K. H., Jiang, Y., Kao, R. Y. T., Lu, H. T., Fan, K. W., Cheng, V. C. C., Tsui, W. H. W., Hung, I. F. N., & Lee, T. S. W. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.03.003 · Cited by 534
A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice
SHIBATA, S. (2000) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.120.10_849 · Cited by 523
Isbrucker, R. A., & Burdock, G. A. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.06.002 · Cited by 501
Glycyrrhizic acid inhibits virus growth and inactivates virus particles
Pompei, R., Flore, O., Marccialis, M. A., Pani, A., & Loddo, B. (1979) · Nature · doi:10.1038/281689a0 · Cited by 464
Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS−Coronavirus
Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, G. A., Doerr, H. W., & Cinatl, J. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0493008 · Cited by 416
Trease and Evans Pharmacognosy
Phillipson, J. D. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00161-7 · Cited by 405
The long term efficacy of glycyrrhizin in chronic hepatitis C patients
Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., & Kumada, H. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970415)79:8<1494::aid-cncr8>3.0.co;2-b · Cited by 403
A history of the therapeutic use of liquorice in Europe
Fiore, C., Eisenhut, M., Ragazzi, E., Zanchin, G., & Armanini, D. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.015 · Cited by 389
Self-citation
Cited by
Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., Fukushima, E. O., Akashi, T., Aoki, T., Saito, K., et al. (2011) · The Plant Cell · doi:10.1105/tpc.110.082685 · Cited by 331
Ji, S., Li, Z., Song, W., Wang, Y., Liang, W., Li, K., Tang, S., Wang, Q., Qiao, X., Zhou, D., et al. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00877 · Cited by 242
Arora, R., Chawla, R., Marwah, R., Arora, P., Sharma, R. K., Kaushik, V., Goel, R., Kaur, A., Silambarasan, M., Tripathi, R. P., et al. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2011/586506 · Cited by 117
Effect of glycyrrhizic acid on scopolamine-induced cognitive impairment in mice
Ban, J. Y., Park, H. K., & Kim, S. K. (2020) · International Neurourology Journal · doi:10.5213/inj.2040154.077 · Cited by 40
Liu, J., Luo, L., Zhang, H., Jia, B., Lu, J., Li, P., & Chen, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.04.019 · Cited by 15
Metadata
- Authors
- Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., & Bielenberg, J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2007-09-20
- Volume
- 22
- Issue
- 2
- Pages
- 141-148
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1977828927
- Cited by
- 458
- References
- 35
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Antiviral effects of Glycyrrhiza species. https://app.cochat.ai/papers/10.1002/ptr.2295
- The paper
- Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., & Bielenberg, J. (2008). Antiviral effects of Glycyrrhiza species. Phytotherapy Research. https://doi.org/10.1002/ptr.2295
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
