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Antiviral effects of Glycyrrhiza species
Open accessAbstract
Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus‐induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV‐1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV‐1 with the cell, induction of interferon gamma in T‐cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs. Copyright © 2007 John Wiley & Sons, Ltd.
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Cites
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,346
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., & Doerr, H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13615-x · Cited by 1,158
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds
Chen, F., Chan, K. H., Jiang, Y., Kao, R. Y. T., Lu, H. T., Fan, K. W., Cheng, V. C. C., Tsui, W. H. W., Hung, I. F. N., & Lee, T. S. W. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.03.003 · Cited by 534
A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice
SHIBATA, S. (2000) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.120.10_849 · Cited by 523
Isbrucker, R. A., & Burdock, G. A. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.06.002 · Cited by 501
Glycyrrhizic acid inhibits virus growth and inactivates virus particles
Pompei, R., Flore, O., Marccialis, M. A., Pani, A., & Loddo, B. (1979) · Nature · doi:10.1038/281689a0 · Cited by 464
Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS−Coronavirus
Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, G. A., Doerr, H. W., & Cinatl, J. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0493008 · Cited by 416
Trease and Evans Pharmacognosy
Phillipson, J. D. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00161-7 · Cited by 405
The long term efficacy of glycyrrhizin in chronic hepatitis C patients
Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., & Kumada, H. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970415)79:8<1494::aid-cncr8>3.0.co;2-b · Cited by 403
A history of the therapeutic use of liquorice in Europe
Fiore, C., Eisenhut, M., Ragazzi, E., Zanchin, G., & Armanini, D. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.015 · Cited by 389
Self-citationCurrent lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection
De Clercq, E. (2000) · Medicinal Research Reviews · doi:10.1002/1098-1128(200009)20:5<323::aid-med1>3.0.co;2-a · Cited by 355
Pharmacognosy and Pharmacobiotechnology
Robbers, J. E., Speedie, M. K., & Tyler, V. E. (1996) · Cited by 306
glycyrrhizin as a potential treatment for chronic hepatitis C
Rossum, T. G. J. V., Vulto, Man, R. A. D., Brouwer, & Schalm (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00309.x · Cited by 270
Encyclopedia of dietary supplements
(2005) · Choice Reviews Online · doi:10.5860/choice.43-0034 · Cited by 249
Chemical Modification of Glycyrrhizic Acid As A Route to New Bioactive Compounds for Medicine
Baltina, L. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033368538 · Cited by 244
Kiso, Y., Tohkin, M., Hikino, H., Hattori, M., Sakamoto, T., & Namba, T. (1984) · Planta Medica · doi:10.1055/s-2007-969714 · Cited by 220
Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S., & Yamamoto, N. (1987) · Antiviral Research · doi:10.1016/0166-3542(87)90001-5 · Cited by 218
JEONG, H. G., YOU, H. J., PARK, S. J., MOON, A. R., CHUNG, Y. C., KANG, S. K., & CHUN, H. K. (2002) · Pharmacological Research · doi:10.1016/s1043-6618(02)00121-4 · Cited by 201
Utsunomiya, T., Kobayashi, M., Pollard, R. B., & Suzuki, F. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.3.551 · Cited by 190
History of The Endocrine Effects of Licorice
Armanini, D., Fiore, C., Mattarello, M., Bielenberg, J., & Palermo, M. (2002) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2002-34587 · Cited by 188
Self-citationTherapeutic basis of glycyrrhizin on chronic hepatitis B
SATO, H., GOTO, W., YAMAMURA, J., KUROKAWA, M., KAGEYAMA, S., TAKAHARA, T., WATANABE, A., & SHIRAKI, K. (1996) · Antiviral Research · doi:10.1016/0166-3542(96)00942-4 · Cited by 185
Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro
Baba, M., & Shigeta, S. (1987) · Antiviral Research · doi:10.1016/0166-3542(87)90025-8 · Cited by 184
Herbal medicines for liver diseases in India
THYAGARAJAN, S., JAYARAM, S., GOPALAKRISHNAN, V, HARI, R., JEYAKUMAR, P., & SRIPATHI, M. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.17.s3.30.x · Cited by 168
Ko, H.-C., Wei, B., & Chiou, W. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.03.004 · Cited by 139
Harada, S. (2005) · Biochemical Journal · doi:10.1042/bj20051069 · Cited by 137
Curreli, F., Friedman‐Kien, A. E., & Flore, O. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523334 · Cited by 119
Sasaki, H., Takei, M., Kobayashi, M., Pollard, R. B., & Suzuki, F. (2002) · Pathobiology · doi:10.1159/000069334 · Cited by 108
Wang, J., Guo, J., Li, H., Liu, S., & Zern, M. Α. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00147.x · Cited by 67
Acharya, S. K., Dasarathy, S., Tandon, A., Joshi, Y., & Tandon, B. N. (1993) · PubMed · Cited by 56
Current concepts in SARS treatment
Fujii, T., Iwamoto, A., Nakamura, T., & Iwamoto, A. (2004) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-003-0296-9 · Cited by 52
Glycyrrhizin increases survival of mice with herpes simplex encephalitis.
Sekizawa, T., YANAGI, K., & Itoyama, Y. (2001) · PubMed · Cited by 51
Mori, K., SAKAI, H., Suzuki, S., AKUTSU, Y., ISHIKAWA, M., Imaizumi, M., Tada, K., Aihara, M., SAWADA, Y., YOKOYAMA, M., et al. (1990) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.162.183 · Cited by 44
Enhancement of Anti-Herpetic Activity of Glycyrrhizic Acid by Physiological Proteins
Lampis, G., Deidda, D., Pinza, M., & Pompei, R. (2001) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020101200206 · Cited by 39
Ohtsuki, K., & Iahida, N. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80292-4 · Cited by 33
Antiviral agents with activity against human retroviruses.
Tochikura, T. S., Nakashima, H., & Yamamoto, N. (1989) · PubMed · Cited by 25
Cited by
Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., Fukushima, E. O., Akashi, T., Aoki, T., Saito, K., et al. (2011) · The Plant Cell · doi:10.1105/tpc.110.082685 · Cited by 331
Ji, S., Li, Z., Song, W., Wang, Y., Liang, W., Li, K., Tang, S., Wang, Q., Qiao, X., Zhou, D., et al. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00877 · Cited by 242
Arora, R., Chawla, R., Marwah, R., Arora, P., Sharma, R. K., Kaushik, V., Goel, R., Kaur, A., Silambarasan, M., Tripathi, R. P., et al. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2011/586506 · Cited by 117
Effect of glycyrrhizic acid on scopolamine-induced cognitive impairment in mice
Ban, J. Y., Park, H. K., & Kim, S. K. (2020) · International Neurourology Journal · doi:10.5213/inj.2040154.077 · Cited by 40
Liu, J., Luo, L., Zhang, H., Jia, B., Lu, J., Li, P., & Chen, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.04.019 · Cited by 15
Metadata
- Authors
- Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., & Bielenberg, J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2007-09-20
- Volume
- 22
- Issue
- 2
- Pages
- 141-148
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1977828927
- Cited by
- 458
- References
- 35
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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