The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
Open accessAbstract
Summary The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.
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Cites
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
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Cited by
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
Cheng, V. C. C., Lau, S. K. P., Woo, P. C. Y., & Yuen, K. Y. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00023-07 · Cited by 1,192
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
Bojkova, D., Klann, K., Koch, B., Widera, M., Krause, D., Ciesek, S., Cinatl, J., & Münch, C. (2020) · Nature · doi:10.1038/s41586-020-2332-7 · Cited by 1,010
Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review
Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6178 · Cited by 804
Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome
Hendren, N. S., Drazner, M. H., Bozkurt, B., & Cooper, L. T. (2020) · Circulation · doi:10.1161/circulationaha.120.047349 · Cited by 576
Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)
Zhang, Q., & Ye, M. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.07.072 · Cited by 549
Metadata
- Authors
- Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., & Doerr, H.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 361
- Issue
- 9374
- Pages
- 2045-2046
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2105037592
- Cited by
- 1,158
- References
- 1
- FWCI
- 37.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., & Doerr, H. (2003). Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet. https://doi.org/10.1016/s0140-6736(03)13615-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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