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A Comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials
Abstract
Panax ginseng C.A. Meyer is a well‐known medicinal herb native to China and Korea, and has been used as a herbal remedy in eastern Asia for thousands of years. However, there is different evidence of ginseng efficacy between traditional Chinese medicine (TCM), modern pharmacological experiments and clinical trials. In TCM, ginseng is a highly valued herb and has been applied to a variety of pathological conditions and illnesses such as hypodynamia, anorexia, shortness of breath, palpitation, insomnia, impotence, hemorrhage and diabetes. Modern pharmacological experiments have proved that ginseng possesses multiple constituents (ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, etc.) and actions (central nervous system effects, neuroprotective effect, immunomodulation, anticancer, etc.), ginsenosides as the active ingredients, especially, having antioxidant, antiinflammatory, antiapoptotic and immunostimulant properties. Recently, ginseng has been studied in a number of randomized controlled trials investigating its effect mainly on physical and psychomotor performance, cognitive function, immunomodulation, diabetes mellitus, cardiovascular risk factors, quality of life, as well as adverse effects. Equivocal results have been demonstrated for many of these indications. Because of the poor quality of most clinical trials on ginseng, reliable clinical data in humans are still lacking. Therefore, a broader understanding of medical knowledge and reasoning on ginseng is necessary. Copyright © 2008 John Wiley & Sons, Ltd.
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Cites
Attele, A. S., Wu, J. A., & Yuan, C.-S. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00212-9 · Cited by 1,866
Stuart, G. A., & Smith, F. P. (1911) · American Presbyterian Mission Press eBooks · doi:10.5962/bhl.title.25114 · Cited by 505
Recent advances on ginseng research in China
Chang-Xiao, L., & Pei-Gen, X. (1992) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(92)90057-x · Cited by 421
Panax ginseng: A Systematic Review of Adverse Effects and Drug Interactions
Coon, J. T., & Ernst, E. (2002) · Drug Safety · doi:10.2165/00002018-200225050-00003 · Cited by 390
The efficacy of ginseng. A systematic review of randomised clinical trials
Vogler, B. K., Pittler, M. H., & Ernst, E. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050674 · Cited by 364
Chinese Materia Medica: Chemistry, Pharmacology and Applications
Zhu, Y.-P. (2024) · CRC Press eBooks · doi:10.1201/9781003580782 · Cited by 338
Cho, W. C. S., Chung, W.-S., Lee, S. K. W., Leung, A. W. N., Cheng, C. H. K., & Yue, K. K. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.056 · Cited by 272
The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies
Tyler, V. E. (1981) · Medical Entomology and Zoology · Cited by 262
Inhibition of Tumor Angiogenesis and Metastasis by a Saponin of Panax ginseng, Ginsenoside-Rb2.
SATO, K., MOCHIZUKI, M., SAIKI, I., YOO, Y., SAMUKAWA, K., & AZUMA, I. (1994) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.17.635 · Cited by 211
The angiosuppressive effects of 20(R)- ginsenoside Rg3
Yue, P. Y. K., Wong, D. Y. L., Wu, P. K., Leung, P. Y., Mak, N. K., Yeung, H. W., Liu, L., Cai, Z., Jiang, Z.-H., Fan, T. P. D., et al. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.034 · Cited by 206
Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats
Tian, J., Fu, F., Geng, M., Jiang, Y., Yang, J., Jiang, W., Wang, C., & Liu, K. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.030 · Cited by 199
Wakabayashi, C., Hasegawa, H., Murata, J., & SAIKI, I. (1997) · PubMed · Cited by 194
Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root
Lim, J.-H., Wen, T.-C., Matsuda, S., Tanaka, J., Maeda, N., Peng, H., Aburaya, J., Ishihara, K., & Sakanaka, M. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00041-2 · Cited by 185
Keum, Y.-S., Han, S. S., Chun, K.-S., Park, K.-K., Park, J.-H., Lee, S. K., & Surh, Y.-J. (2003) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00323-8 · Cited by 185
Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress
Chen, X. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01945-9 · Cited by 166
Anti-diabetic effect of ginsenoside Re in ob/ob mice
Xie, J., Mehendale, S. R., Li, X., Quigg, R. J., Wang, X., Wang, C., Wu, J. A., Aung, H. H., Rue, P. A., Bell, G. I., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.10.010 · Cited by 151
Ginsenoside Rh4, A Genuine Dammarane Glycoside from Korean Red Ginseng
Baek, N., Kim, D., Lee, Y., et al. (1996) · Planta Medica · doi:10.1055/s-2006-957816 · Cited by 144
The effects of Panax ginseng on quality of life
Coleman, C. I., Hebert, J. H., & Reddy, P. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00467.x · Cited by 133
Leung, K. W., Pon, Y. L., Wong, R. N., & Wong, A. S. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606698200 · Cited by 131
Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress1
Chen, X., Yi-can, Z., Chen, Y., Zhu, Y., Fang, F. A. N. G., & Chen, L. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00019.x · Cited by 131
Systematic Review of the Effects of Ginseng on Cardiovascular Risk Factors
Buettner, C., Yeh, G. Y., Phillips, R. S., Mittleman, M. A., & Kaptchuk, T. J. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g216 · Cited by 130
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (2000) · Sports Medicine · doi:10.2165/00007256-200029020-00004 · Cited by 124
Wen, T., Yoshimura, H., Matsuda, S., Lim, J.-H., & Sakanaka, M. (1995) · Acta Neuropathologica · doi:10.1007/s004010050387 · Cited by 122
Ginseng, Sex Behavior, and Nitric Oxide
Murphy, L. L., & Lee, T. J.-F. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04081.x · Cited by 120
Signaling pathway of ginsenoside‐Rg1 leading to nitric oxide production in endothelial cells
Leung, K. W., Cheng, Y., Mak, N. K., Chan, K. K. C., Fan, T., & Wong, R. N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.080 · Cited by 119
Kim, N. D., Kim, E. M., Kang, K. W., et al. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705490 · Cited by 116
Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice
Yokozawa, T., Satoh, A., & Cho, E. J. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022449 · Cited by 114
Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation
Lee, E.-J., Ko, E., Lee, J., Rho, S., Ko, S., Shin, M., Min, B.-I., Hong, M., Kim, S.-Y., & Bae, H. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2003.12.007 · Cited by 111
Rhim, H., Kim, H., Lee, D.-Y., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01613-2 · Cited by 110
Cho, J., Park, W., Lee, S., Ahn, W., & Lee, Y. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031823 · Cited by 109
Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain
Salim, K. N., McEwen, B. S., & Chao, H. M. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00042-9 · Cited by 106
The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response
Rivera, E., Pettersson, F. E., Inganäs, M., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.04.007 · Cited by 105
Furukawa, T., Bai, C., Kaihara, A., Ozaki, E., Kawano, T., Nakaya, Y., Awais, M., Sato, M., Umezawa, Y., & Kurokawa, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.028134 · Cited by 101
Evaluation of Commercial Ginseng Products
Liberti, L. E., & Marderosian, A. D. (1978) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600671050 · Cited by 100
Min, J., Kim, J.-H., Cho, Y.-L., Maeng, Y., Lee, S., Pyun, B., Kim, Y.-M., Park, J. H., & Kwon, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.129 · Cited by 99
Huang, Y., Chen, C., Chen, S.-C., Lai, P.-H., Liang, H., Chang, Y., Yu, L.-C., & Sung, H. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-2500-3 · Cited by 98
Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors
Sala, F., Mulet, J., Choi, S., Jung, S.-Y., Nah, S.-Y., Rhim, H., Valor, L. M., Criado, M., & Sala, S. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.1052 · Cited by 80
Mannaa, F. A. E., Abdel-Wahhab, M. A., Ahmed, H. H., & Park, M. H. (2006) · Journal of Applied Toxicology · doi:10.1002/jat.1128 · Cited by 80
Bae, E., Kim, E., Park, J., Kim, H.-S., Ryu, J., & Kim, D. (2006) · Planta Medica · doi:10.1055/s-2006-931563 · Cited by 75
Xue, J., Liu, Z., Hu, J., Chen, H., Zhang, J., & Chen, N. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.106 · Cited by 72
Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells
Shen, L., & Zhang, J. (2004) · Neurological Research · doi:10.1179/016164104225016047 · Cited by 70
Stereospecificity of Ginsenoside Rg3 Action on Ion Channels
Jeong, S. M., Lee, J., Kim, J., Lee, B.-H., Yoon, I., Lee, J., Kim, D., Rhim, H., Kim, Y., & Nah, S.-Y. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13128-1 · Cited by 67
Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes
Bai, C., Sunami, A., Namiki, T., Sawanobori, T., & Furukawa, T. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02174-5 · Cited by 59
Xu, B., Liu, C., Gao, X., Zhang, W., Wang, S., & Cao, Y.-L. (2004) · Journal of Asian Natural Products Research · doi:10.1080/10286020410001690172 · Cited by 58
Self-citationEmbryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture
Chan, L. Y.-S., Chiu, P. Y., & Lau, T. K. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.06.001 · Cited by 54
Epidermis proliferative effect of thePanax ginseng Ginsenoside Rb2
Choi, S. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02975265 · Cited by 51
Ginseng: Its History, Dispersion, and Folk Tradition
Goldstein, B. (1975) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x75000244 · Cited by 45
Protective effect of ginsenoside Rg1 on MPP + -induced apoptosis in SHSY5Y cells
Chen, X.-C., Fang, F., Zhu, Y.-G., Chen, L.-M., Zhou, Y.-C., & Chen, Y.-X. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0005-y · Cited by 39
Zhang, H., Zhou, Q., Li, X., Xie, Y., Duan, X., Min, F.-L., Liu, B., & Yuan, Z.-G. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02974276 · Cited by 38
Ginsenoside Re attenuate β-amyloid and serum-free induced neurotoxicity in PC12 cells
Ji, Z., Dong, T. T. X., Ye, W., et al. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.02.004 · Cited by 38
Joo, S. S., & Lee, D. I. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02972981 · Cited by 34
Wang, X. Y., Chen, J., & Zhang, J. T. (2001) · PubMed · Cited by 32
GINSENG-QUALITY SAFETY AND EFFICACY?
Phillipson, J. D., & Anderson, L. A. (1984) · Cited by 29
Lee, H., Gonzalez, F. J., & Yoon, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.197 · Cited by 25
Modulation of Protein Kinase C Activity in NIH 3T3 Cells by Plant Glycosides fromPanax ginseng
Byun, B. H., Shin, I., Yoon, Y. S., Kim, S., & Joe, C. O. (1997) · Planta Medica · doi:10.1055/s-2006-957719 · Cited by 24
Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats
Stancheva, S. L., & Alova, L. G. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90435-z · Cited by 20
[Immunoregulatory effects of ginsenoside Rg1 in aged rats].
Liu, M., & Jt, Z. (1995) · PubMed · Cited by 19
[Studies on the mechanisms of immunoregulatory effects of ginsenoside Rg1 in aged rats].
Liu, M., & Jt, Z. (1996) · PubMed · Cited by 19
Kang, Y. J., Sohn, J., & Chang, K. C. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.12.016 · Cited by 18
Chen, X., Li-min, C., Zhu, Y., Fang, F., Yi-can, Z., & Zhao, C. (2003) · PubMed · Cited by 15
Kim, H.-S., Hwang, S.-L., & Oh, S. (2000) · Neurochemical Research · doi:10.1023/a:1007634432095 · Cited by 14
Influence of ginsenoside Rb1 on brain neurosteroid during acute immobilization stress
Lee, S. E., Jung, B. H., Choi, S. Y., Kim, S. Y., Lee, E. H., & Chung, B. C. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02969266 · Cited by 12
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Beneficial effects of green tea: A literature review
Chacko, S. M., Thambi, P. T., Kuttan, R., & Nishigaki, I. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-13 · Cited by 987
Molecular activities, biosynthesis and evolution of triterpenoid saponins
Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Pharmacology of ginsenosides: a literature review
Leung, K., & Wong, A. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-20 · Cited by 537
Qi, F., Zhao, L., Zhou, A., Zhang, B., Li, A., Wang, Z., & Han, J. (2015) · BioScience Trends · doi:10.5582/bst.2015.01019 · Cited by 481
Self-citationAraghizadeh, A., Kohanteb, J., & Fani, M. M. (2013) · Medical Principles and Practice · doi:10.1159/000348299 · Cited by 345
Metadata
- Authors
- Xiang, Y., Shang, H., Gao, X., & Zhang, B.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2008-06-20
- Volume
- 22
- Issue
- 7
- Pages
- 851-858
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1968458245
- Cited by
- 298
- References
- 62
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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