Ameliorating effect of balloon flower saponin on the ethanol‐induced memory impairment in mice
Abstract
The ameliorating effect of the root extract of Platycodon grandiflorum (Campanulaceae) on ethanol-induced cognitive dysfunction in mice was investigated. The mice with repeated administration of the root extract of P. grandiflorum, crude saponin fraction and platycoside E, a main ingredient of crude saponin fraction, showed a markedly prolonged step-through latency period (STL) on the passive avoidance task performed after acute ethanol intoxication, respectively. The present results suggest that the memory enhancing effect of the extract was ascribed mainly to the saponin fraction and that saponin of P. grandiflorum, particularly platycoside E could exert a beneficial effect on memory impairment in mice.
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Saponins, the main chemical constituent of butanol fraction of E. prostrate, prevented ethanol induced memory impairment in rats.
“Saponins, the main chemical constituent of butanol fraction of E. prostrate, prevented ethanol induced memory impairment in rats [208].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [208]
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- Authors
- Choi, Y. H., Kim, Y. S., Yeo, S. J., Roh, S. H., Jeong, Y. C., Kang, J. S., & Ryu, S. Y.
- Affiliations
- Korea Research Institute of Chemical Technology (KR)
- Chungnam National University (KR)
- International University of Korea (KR)
- Corresponding author
- Kang, Jong Seong
- Ryu, Shi Yong
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2008-06-20
- Volume
- 22
- Issue
- 7
- Pages
- 973-976
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2099342207
- Cited by
- 20
- References
- 12
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 4 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of Korea (MOST); Inter-Institutional Collaboration Research Program under Korea Research Council for Industrial Science and Technology (KOCI), Korea
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Keywords
- Platycodon grandiflorum, ethanol-induced memory impairment, cognitive impairment, passive avoidance, saponin fraction, root extract, memory enhancement, ethanol intoxication
- MeSH terms
- Ethanol, Animals, Avoidance Learning, Behavior, Animal, Central Nervous System Depressants, Cognition, Cognition Disorders, Disease Models, Animal, Male, Memory, Memory Disorders, Mice, Inbred ICR, Plant Extracts, Saponins, Plant Roots, Campanulaceae, Mice
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