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Cited by 89Essential Oils and Antimicrobial ActivityMedicinal Plant ResearchBioactive natural compounds

Eugenol a valuable compound for in vitro experimental research and worthwhile for further in vivo investigation

Laekeman, G. M., van Hoof, L., Haemers, A., Berghe, D. A. Vanden, Herman, A. G., Vlietinck, A. J.·1990·Phytotherapy Research
DOI 10.1002/ptr.2650040304
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Abstract

Abstract Eugenol and isoeugenol are responsible for several pharmacological activities exhibited by nutmeg preparations. We studied their antimicrobial and antiaggregation activity in vitro and their influence on platelet function ex vivo. At the same time biogenetically or metabolically related derivatives were tested. Eugenol and isoeugenol (1 mg/mL) showed pronounced antibacterial properties: growth inhibition of 6 out of 10 Gram + and Gram – microorganisms was comparable with neomycin (500 μg/mL). Growth inhibition was even more pronounced for Candida species in comparison with nystatin (5000 U/mL). Eugenol and some of its analogues inhibited growth of Aspergillus and Trichophyton species at concentrations of 100 μg/mL. However, cytotoxicity of the compounds will limit their systemical use. The IC50, of eugenol (3.0 × 10−7 M) and isoeugenol (7.2 × 10−7 M), were comparable with indomethacin (2.2 × 10−7 M) on platelet aggregation. Their free hydroxy group was necessary for pharmacological activity. Ex vivo results revealed a dose‐dependent blocking effect on the thromboxane biosynthesis by rat blood platelets: 66% inhibition by 50 mg/kg to 96% inhibition by 400 mg/kg. Eugenol and acetyleugenol given orally to rabbits had mean biological half‐lives of 95 and 60 min respectively. Eugenol might be an interesting basic structure for drug design.

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  • Most antimicrobial activity of phenylpropenes is conferred by their free hydroxyl groups.

    “Most antimicrobial activity of these molecules is conferred by their free hydroxyl groups [39].”

    From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [39]

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Authors
Laekeman, G. M., van Hoof, L., Haemers, A., Berghe, D. A. V., Herman, A. G., & Vlietinck, A. J.
Affiliations
University of Antwerp (BE)
Corresponding author
Laekeman, G. M.
ORCID
Herman, A. G.
Venue
Phytotherapy Research
Publisher
Wiley
Published
1990-06
Volume
4
Issue
3
Pages
90-96
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.2650040304
OpenAlex
W1992851681
Cited by
89
References
32
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5703 d)
Locations
Phytotherapy Research (publishedVersion)
Funders
Department of Science and Technology, Ministry of Science and Technology, India
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
eugenol, isoeugenol, nutmeg, antimicrobial activity, antibacterial activity, antifungal activity, Candida, Aspergillus, Trichophyton, platelet aggregation, platelet function, thromboxane synthesis, cytotoxicity, pharmacokinetics, drug design

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