The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds
Abstract
Aqueous and ethanol extracts of propolis were analysed phytochemically and examined for their antiviral activity in vitro. Different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. The antiviral effect of propolis extracts and selected constituents, e.g. caffeic acid (1), p‐coumaric acid (2), benzoic acid (3), galangin (4), pinocembrin (5) and chrysin (6) against herpes simplex virus type 1 (HSV‐1) was analysed in cell culture. The 50% inhibitory concentration (IC 50) of aqueous and ethanol propolis extracts for HSV‐1 plaque formation was determined at 0.0004% and 0.000035%, respectively. Both propolis extracts exhibited high levels of antiviral activity against HSV‐1 in viral suspension tests, plaque formation was significantly reduced by >98%. In order to determine the mode of antiviral action of propolis, the extracts were added at different times during the viral infection cycle. Both propolis extracts exhibited high anti‐HSV‐1 activity when the viruses were pretreated with these drugs prior to infection. Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. However, the extracts containing many different components exhibited significantly higher antiherpetic effects as well as higher selectivity indices than single isolated constituents. Propolis extracts might be suitable for topical application against herpes infection. Copyright © 2009 John Wiley & Sons, Ltd.
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Cites
Review of the biological properties and toxicity of bee propolis (propolis)
Burdock, G. A. (1998) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(97)00145-2 · Cited by 1,603
Propolis: chemical composition, biological properties and therapeutic activity
Marcucci, M. C. (1995) · Apidologie · doi:10.1051/apido:19950202 · Cited by 1,323
Antibacterial, antifungal and antiviral activity of propolis of different geographic origin
Kujumgiev, A., Tsvetkova, I., Serkedjieva, Y., Bankova, V, Christov, R., & Popov, S. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00131-7 · Cited by 1,106
Age‐Specific Prevalence of Infection with Herpes Simplex Virus Types 2 and 1: A Global Review
Smith, J. S., & Robinson, N. J. (2002) · The Journal of Infectious Diseases · doi:10.1086/343739 · Cited by 885
Recent progress in pharmacological research of propolis
Banskota, A. H., Tezuka, Y., & Kadota, S. (2001) · Phytotherapy Research · doi:10.1002/ptr.1029 · Cited by 862
Phenolic compounds from Brazilian propolis with pharmacological activities
Marcucci, M. C., Ferreres, F., Garcı́a-Viguera, C., Bankova, V. S., De Castro, S. L., Dantas, A. P., Valente, P. H. M., & Paulino, N. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00326-3 · Cited by 528
In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens
Koo, H., Gomes, B. P. F. A., Rosalen, P. L., Ambrosano, G. M. B., Park, Y. K., & Cury, J. A. (2000) · Archives of Oral Biology · doi:10.1016/s0003-9969(99)00117-x · Cited by 419
Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin
Russo, A., Longo, R., & Vanella, A. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00187-9 · Cited by 387
Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition
Popova, M., Silici, S., Kaftanoglu, O., & Bankova, V. (2005) · Phytomedicine · doi:10.1016/j.phymed.2003.09.007 · Cited by 308
Amoros, M., Simõs, C. M. O., Girre, L., Sauvager, F., & Cormier, M. (1992) · Journal of Natural Products · doi:10.1021/np50090a003 · Cited by 299
Cited by
Antibacterial properties of propolis
Przybyłek, I., & Karpiński, T. M. (2019) · Molecules · doi:10.3390/molecules24112047 · Cited by 683
Silva-Carvalho, R., Baltazar, F., & Almeida-Aguiar, C. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/206439 · Cited by 333
Metadata
- Authors
- Schnitzler, P., Neuner, A., Nolkemper, S., Zundel, C., Nowack, H., Sensch, K. H., & Reichling, J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 24
- Issue
- S1
- Pages
- S20-8
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2047760217
- Cited by
- 253
- References
- 27
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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