The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders
Abstract
Berberine, an isoquinoline alkaloid of the protoberberine type found in an array of plants, has been used in Indian and Chinese medicines as an antimicrobial, stomachic, bitter tonic and in the treatment of oriental sores. Although pharmacological investigations of berberine have been reported by many in the past, there is renewed interest in berberine because of its reported beneficial effect in various neurodegenerative and neuropsychiatric disorders. The alkaloid is reported to modulate neurotransmitters and their receptor systems in the brain. This review attempts to discuss the pharmacological basis of the use of berberine in various central nervous system and related disorders. Its protective effect in Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety are highlighted. However, more detailed clinical trials along with a safety assessment of berberine are warranted for positioning the alkaloid in the treatment of neurological disorders. Copyright © 2009 John Wiley & Sons, Ltd.
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Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573 · cited 2×
“Zhang et al. (2008) studied the antidiabetic properties of berberine (1000 mg daily for 3 months) and it was concluded that berberine is safe to be employed in humans, with the exception that it produced mild to moderate constipation in some individuals as compared to a placebo control group.”
BackgroundCardiovascular effects of berberine in patients with severe congestive heart failure
Marin ‐ NETO, J. A., Maciel, B. C., Secches, A. L., & Gallo, L. (1988) · Clinical Cardiology · doi:10.1002/clc.4960110411 · Cited by 128
Cited by
Neag, M. A., Mocan, A., Echeverría, J., Pop, R. M., Bocsan, C. I., Crişan, G., & Buzoianu, A. D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00557 · Cited by 562
Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
Durairajan, S. S. K., Liu, L.-F., Lu, J.-H., Chen, L.-L., Yuan, Q., Chung, S. K., Huang, L., Li, X.-S., Huang, J.-D., & Li, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.016 · Cited by 271
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E. (2016) · Molecules · doi:10.3390/molecules21040518 · Cited by 107
Plants-derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms
Elufioye, T. O., Berida, T. I., & Habtemariam, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3574012 · Cited by 107
Metadata
- Authors
- Kulkarni, S. K., & Dhir, A.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-12-08
- Volume
- 24
- Issue
- 3
- Pages
- 317-324
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1988521712
- Cited by
- 367
- References
- 4
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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