The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders
Abstract
Berberine, an isoquinoline alkaloid of the protoberberine type found in an array of plants, has been used in Indian and Chinese medicines as an antimicrobial, stomachic, bitter tonic and in the treatment of oriental sores. Although pharmacological investigations of berberine have been reported by many in the past, there is renewed interest in berberine because of its reported beneficial effect in various neurodegenerative and neuropsychiatric disorders. The alkaloid is reported to modulate neurotransmitters and their receptor systems in the brain. This review attempts to discuss the pharmacological basis of the use of berberine in various central nervous system and related disorders. Its protective effect in Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety are highlighted. However, more detailed clinical trials along with a safety assessment of berberine are warranted for positioning the alkaloid in the treatment of neurological disorders. Copyright © 2009 John Wiley & Sons, Ltd.
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Cites
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Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
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Alkaloids Isolated from Natural Herbs as the Anticancer Agents
Lu, J.-J., Bao, J.-L., Chen, X.-P., Huang, M., & Wang, Y.-T. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/485042 · Cited by 384
Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
Durairajan, S. S. K., Liu, L.-F., Lu, J.-H., Chen, L.-L., Yuan, Q., Chung, S. K., Huang, L., Li, X.-S., Huang, J.-D., & Li, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.016 · Cited by 271
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
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Och, A., Och, M., Nowak, R., Podgórska, D., & Podgórski, R. (2022) · Molecules · doi:10.3390/molecules27041351 · Cited by 104
Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice
Guo, Y., Pope, C., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.058 · Cited by 77
The mechanism of berberine alleviating metabolic disorder based on gut microbiome
Wang, H., Zhang, H., Gao, Z., Zhang, Q., & Gu, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854885 · Cited by 69
“, 2020), and neurological diseases (Kulkarni and Dhir, 2010).”
Zilaee, M., Kermany, T., Tavalaee, S., Salehi, M., Ghayour-Mobarhan, M., & Ferns, G. A. A. (2014) · Phytotherapy Research · doi:10.1002/ptr.5117 · Cited by 24
Wang, B., Deng, A.-J., Li, Z.-H., Wang, N., & Qin, H.-L. (2020) · Molecules · doi:10.3390/molecules25081871 · Cited by 23
(2013) · PubMed · Cited by 21
Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
Rabiee, R., Hosseini Hooshiar, S., Ghaderi, A., & Jafarnejad, S. (2023) · Neurochemical Research · doi:10.1007/s11064-022-03798-4 · Cited by 11
Yadawa, A. K., Srivastava, P., Singh, A., Kumar, R., Arya, J. K., & Rizvi, S. I. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01350-7 · Cited by 10
Metadata
- Authors
- Kulkarni, S. K., & Dhir, A.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-12-08
- Volume
- 24
- Issue
- 3
- Pages
- 317-324
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1988521712
- Cited by
- 367
- References
- 4
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
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