Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Open accessAbstract
The word dementia describes a class of heterogeneous diseases which etiopathogenetic mechanisms are not well understood. There are different types of dementia, among which, Alzheimer’s disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) are the more common. Currently approved pharmacological treatments for most forms of dementia seem to act only on symptoms without having profound disease-modifying effects. Thus, alternative strategies capable of preventing the progressive loss of specific neuronal populations are urgently required. In particular, the attention of researchers has been focused on phytochemical compounds that have shown antioxidative, anti-amyloidogenic, anti-inflammatory and anti-apoptotic properties and that could represent important resources in the discovery of drug candidates against dementia. In this review, we summarize the neuroprotective effects of the main phytochemicals belonging to the polyphenol, isothiocyanate, alkaloid and cannabinoid families in the prevention and treatment of the most common kinds of dementia. We believe that natural phytochemicals may represent a promising sources of alternative medicine, at least in association with therapies approved to date for dementia.
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Many experimental preclinical pharmacological studies have demonstrated the efficacy of phytochemicals in the management of Alzheimer's disease.
“Many experimental preclinical pharmacological studies have demonstrated the efficacy of phytochemicals in the management of AD”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [78]
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Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
- Authors
- Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E.
- Affiliations
- Centro Neurolesi Bonino Pulejo (IT)
- IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
- Corresponding author
- Mazzon, Emanuela
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-04-21
- Volume
- 21
- Issue
- 4
- Pages
- 518
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6274085
- OpenAlex
- W2335863657
- Cited by
- 107
- References
- 250
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 15 · 2023: 7 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 5
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- phytochemicals, dementia, Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, neuroprotection, polyphenols, isothiocyanates, alkaloids, cannabinoids, antioxidant activity, anti-amyloidogenic activity, anti-inflammatory activity, anti-apoptotic effects, disease-modifying therapy, drug candidates
- MeSH terms
- Alzheimer Disease, Animals, Clinical Trials as Topic, Dementia, Humans, Neurons, Dementia, Vascular, Neuroprotective Agents, Lewy Body Disease, Frontotemporal Dementia, Phytochemicals
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