Cited by 107Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

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Libro, Rosaliana, Giacoppo, Sabrina, Soundara Rajan, Thangavelu, Bramanti, Placido, Mazzon, Emanuela·2016·Molecules

Abstract

The word dementia describes a class of heterogeneous diseases which etiopathogenetic mechanisms are not well understood. There are different types of dementia, among which, Alzheimer’s disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) are the more common. Currently approved pharmacological treatments for most forms of dementia seem to act only on symptoms without having profound disease-modifying effects. Thus, alternative strategies capable of preventing the progressive loss of specific neuronal populations are urgently required. In particular, the attention of researchers has been focused on phytochemical compounds that have shown antioxidative, anti-amyloidogenic, anti-inflammatory and anti-apoptotic properties and that could represent important resources in the discovery of drug candidates against dementia. In this review, we summarize the neuroprotective effects of the main phytochemicals belonging to the polyphenol, isothiocyanate, alkaloid and cannabinoid families in the prevention and treatment of the most common kinds of dementia. We believe that natural phytochemicals may represent a promising sources of alternative medicine, at least in association with therapies approved to date for dementia.

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Authors
Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E.
Affiliations
  • Centro Neurolesi Bonino Pulejo (IT)
  • IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
Corresponding author
Mazzon, Emanuela
Venue
Molecules
Publisher
MDPI AG
Published
2016-04-21
Volume
21
Issue
4
Pages
518
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2335863657
Cited by
107
References
250
Citations by year
2026: 2 · 2025: 15 · 2024: 15 · 2023: 7 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 5
FWCI
2.22
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
phytochemicals, dementia, Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, neuroprotection, polyphenols, isothiocyanates, alkaloids, cannabinoids, antioxidant activity, anti-amyloidogenic activity, anti-inflammatory activity, anti-apoptotic effects, disease-modifying therapy, drug candidates
MeSH terms
Alzheimer Disease, Animals, Clinical Trials as Topic, Dementia, Humans, Neurons, Dementia, Vascular, Neuroprotective Agents, Lewy Body Disease, Frontotemporal Dementia, Phytochemicals

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