The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Puerarin: A Review of Pharmacological Effects
Abstract
Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin. Copyright © 2013 John Wiley & Sons, Ltd.
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1 retracted
Puerarin injection for unstable angina pectoris
Wang, Q., Wu, T., Chen, X. Y., Duan, X., Zheng, J., Qiao, J., Zhou, L., Wei, J., & Ni, J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004196.pub2 · Cited by 55
RetractedVasoregulation by the β1 subunit of the calcium-activated potassium channel
Brenner, R., Peréz, G. J., Bonev, A. D., Eckman, D. M., Kosek, J. C., Wiler, S. W., Patterson, A. J., Nelson, M. T., & Aldrich, R. W. (2000) · Nature · doi:10.1038/35038011 · Cited by 796
Soy Isoflavones and Cancer Prevention: CLINICAL SCIENCE REVIEW
Sarkar, F. H., & Li, Y. (2003) · Cancer Investigation · doi:10.1081/cnv-120023773 · Cited by 383
Wong, K. H., Li, G. Q., Li, K. M., Razmovski-Naumovski, V., & Chan, K. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.02.001 · Cited by 373
Diabetes is an inflammatory disease: evidence from traditional Chinese medicines
Xie, W., & Du, L. (2011) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01336.x · Cited by 304
Antihyperglycemic Effect of Puerarin in Streptozotocin-Induced Diabetic Rats
Hsu, F.-L., Liu, I.-M., Kuo, D.-H., Chen, W.-C., Su, H.-C., & Cheng, J.-T. (2003) · Journal of Natural Products · doi:10.1021/np0203887 · Cited by 221
Park, O. J., & Surh, Y.-J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.06.001 · Cited by 203
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Puerarin protects rat pancreatic islets from damage by hydrogen peroxide
Fu-Liang, X., Sun, X., Lu, G., Yang, X., & Xu, H. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.024 · Cited by 152
Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
Liu, C., Ma, J., & Sun, Y.-Z. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.11.015 · Cited by 151
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Metadata
- Authors
- Zhou, Y., Zhang, H., & Peng, C.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2013-12-13
- Volume
- 28
- Issue
- 7
- Pages
- 961-975
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1558352361
- Cited by
- 687
- References
- 85
- FWCI
- 40.79
- Type
- journal article
- Language
- en
- Open access
- closed
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