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Turmeric ( Curcuma longa ) and its major constituent (curcumin) as nontoxic and safe substances: Review
Abstract
Curcumin is the major constituent of turmeric ( Curcuma longa ). Turmeric has been widely used as a spice in foods and for therapeutic applications such as anti‐inflammatory, antihyperlipidemic, and antimicrobial activities. Turmeric and curcumin are nonmutagenic and nongenotoxic. Oral use of turmeric and curcumin did not have reproductive toxicity in animals at certain doses. Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 4–7 weeks. However, some adverse effects such as gastrointestinal upsets may occur. Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article. In addition, curcumin is known as a generally recognized as safe substance. This review discusses the safety and toxicity of turmeric and curcumin in medicine. Turmeric and curcumin are nontoxic for human especially in oral administration. Turmeric and curcumin are also safe in animals. They are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed.
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Self-citation
Metadata
- Authors
- Soleimani, V., Sahebkar, A., & Hosseinzadeh, H.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Corresponding author
- Hosseinzadeh, Hossein
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2018-02-26
- Volume
- 32
- Issue
- 6
- Pages
- 985-995
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2789343877
- Cited by
- 579
- References
- 106
- Citations by year
- 2026: 43 · 2025: 66 · 2024: 73 · 2023: 81 · 2022: 100 · 2021: 121 · 2020: 49 · 2019: 33 · 2018: 12
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Saffron Plant Research Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Keywords
- turmeric, curcumin, safety, toxicity, reproductive toxicity, oral bioavailability, gastrointestinal adverse effects, nanoformulations, GRAS, anti-inflammatory activity, hypolipidemic activity, antimicrobial activity
- MeSH terms
- Animals, Anti-Inflammatory Agents, Curcumin, Humans, Curcuma, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
