Cited by 599Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

The effect of curcumin (turmeric) on Alzheimer’s disease: An overview

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Mishra, Shrikant, Palanivelu, Kalpana·2008·Annals of Indian Academy of Neurology

Abstract

This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology.

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  1. [4]Shishodia S Sethi G Aggarwal BB Getting back to roots Ann NY Acad Sci 2005 1056 206 17 16387689
  2. [32]DAI Xueling SUN Yaxuan JIANG Zhaofeng Copper (2) potentiation of Alzheimers A-(beta)1-40 cytotoxicity and transition on its secondary structure Acta Biochimica et Biophysica Sinica 1938 11 765 72 17091193
  3. [33]Liu G Huang W Moir RD Vanderburg CR Barry AI Zicheng P Metal exposure and Alzheimers pathogenesis J Structural Biol 2005 155 45 51 16503166

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Authors
Mishra, S., & Palanivelu, K.
Affiliations
United States Department of Veterans Affairs (US)
Corresponding author
Mishra, Shrikant
Venue
Annals of Indian Academy of Neurology
Published
2008
Volume
11
Issue
1
Pages
13
ISSN
0972-2327 (ISSN-L)
OpenAlex
W1979734999
Cited by
599
References
50
Citations by year
2026: 22 · 2025: 32 · 2024: 42 · 2023: 51 · 2022: 59 · 2021: 62 · 2020: 42 · 2019: 45 · 2018: 34 · 2017: 57 · 2016: 35 · 2015: 35 · 2014: 21 · 2013: 27 · 2012: 16
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Annals of Indian Academy of Neurology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
curcumin, turmeric, Alzheimer's disease, dementia, oxidative stress, amyloid plaques, neuroinflammation, metal chelation, antioxidant activity, anti-inflammatory activity, microglia, cognitive function, memory, neuroprotection

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