The effect of curcumin (turmeric) on Alzheimer’s disease: An overview
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This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology.
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Curcumin is the main curcuminoid associated with reduced Alzheimer's disease risk due to its anti-inflammatory activity.
“Moreover, curcumin is the main curcuminoid associated with reduced AD risk due to its anti-inflammatory activity [149].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [149]
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- Authors
- Mishra, S., & Palanivelu, K.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Mishra, Shrikant
- ORCID
- Mishra, Shrikant
- Venue
- Annals of Indian Academy of Neurology
- Published
- 2008
- Volume
- 11
- Issue
- 1
- Pages
- 13
- ISSN
- 0972-2327 (ISSN-L)
- PMC
- PMC2781139
- OpenAlex
- W1979734999
- Cited by
- 599
- References
- 50
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 42 · 2023: 51 · 2022: 59 · 2021: 62 · 2020: 42 · 2019: 45 · 2018: 34 · 2017: 57 · 2016: 35 · 2015: 35 · 2014: 21 · 2013: 27 · 2012: 16
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Annals of Indian Academy of Neurology (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, turmeric, Alzheimer's disease, dementia, oxidative stress, amyloid plaques, neuroinflammation, metal chelation, antioxidant activity, anti-inflammatory activity, microglia, cognitive function, memory, neuroprotection
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