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Cited by 110

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Anticancer activity of limonene: A systematic review of target signaling pathways

Araújo‐Filho, Heitor Gomes de, dos Santos, Jucilene F., Carvalho, Mikaella T. B., Picot, Laurent, Fruitier‐Arnaudin, Ingrid, Groult, Hugo, Quintans‐Júnior, Lucindo J., Quintans, Jullyana S.S.·2021·Phytotherapy Research
DOI 10.1002/ptr.7125
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Abstract

Limonene (LIM) is a monoterpene, which is abundant in essential oils of Citrus fruits peels (Rutaceae). More recently, LIM, as a potential natural anticancer compound, has attracted major attention and exerted a chemopreventive activity, stimulating the detoxification of carcinogenic compounds and limiting tumor growth and angiogenesis in various cancer models. Twenty‐six (26) articles were selected based on previously established criteria. Anticancer activity of LIM was related to the inhibition of tumor initiation, growth, and angiogenesis and the induction of cancer cells apoptosis. LIM was able to increase Bax expression, release cytochrome c, and activate the caspase pathway. In addition, LIM increased the expression of p53 and decreased the activity of Ras/Raf/MEK/ERK and PI3K/Akt pathways. LIM also decreased the expression of VEGF and increased the activities of the Man‐6‐P / IGF2R and TGF‐βIIR receptors. These results highlight LIM as an abundant natural molecule with low toxicity and pleiotropic pharmacological activity in cancer cells, targeting various cell‐signaling pathways critically involved in the initiation, growth, and chemoresistance of cancer cells.

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Metadata

Authors
Araújo‐Filho, H. G. D., dos Santos, J. F., Carvalho, M. T. B., Picot, L., Fruitier‐Arnaudin, I., Groult, H., Quintans‐Júnior, L. J., & Quintans, J. S. S.
Affiliations
  • Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology Federal University of Sergipe São Cristóvão Brazil
  • Laboratory of Neuropharmacology and Integrative Physiology (LNFI), Department of Physiology Federal University of Alagoas Maceió Brazil
  • UMRi CNRS 7266 LIENSs University of La Rochelle La Rochelle France
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2021-04-17
Volume
35
Issue
9
Pages
4957-4970
ISSN
  • 0951-418X
  • 1099-1573
DOI
10.1002/ptr.7125
Cited by
110
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Anticancer activity of limonene: A systematic review of target signaling pathways. https://app.cochat.ai/papers/10.1002/ptr.7125
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Araújo‐Filho, H. G. D., dos Santos, J. F., Carvalho, M. T. B., Picot, L., Fruitier‐Arnaudin, I., Groult, H., Quintans‐Júnior, L. J., & Quintans, J. S. S. (2021). Anticancer activity of limonene: A systematic review of target signaling pathways. Phytotherapy Research. https://doi.org/10.1002/ptr.7125

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