The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology
Abstract
α‐linolenic acid (ALA, 18:3n‐3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA. Information on ALA was collected from the internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library, and Europe PMC using a combination of keywords including “pharmacology,” “metabolism,” “sources.” The following findings are mainly contained. (a) ALA can only be ingested from food and then converted into eicosapentaenoic acid and docosahexaenoic acid in the body. (b) This conversion process is relatively limited and affected by many factors such as dose, gender, and disease. (c) Pharmacological research shows that ALA has the anti‐metabolic syndrome, anticancer, antiinflammatory, anti‐oxidant, anti‐obesity, neuroprotection, and regulation of the intestinal flora properties. (d) There are the most studies that prove ALA has anti‐metabolic syndrome effects, including experimental studies and clinical trials. (e) The therapeutic effect of ALA will be affected by the dosage. In short, ALA is expected to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of ALA.
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Cites
1 retracted
Gao, F., Taha, A. Y., Ma, K., et al. (2012) · AGE · doi:10.1007/s11357-012-9390-1 · Cited by 17
RetractedThe American journal of clinical nutrition
(1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)92305-h · Cited by 3,324
Horton, J. D., Shah, N. A., Warrington, J. A., Anderson, N. N., Park, S. W., Brown, M. S., & Goldstein, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534923100 · Cited by 1,270
Conversion of α -linolenic acid to longer-chain polyunsaturated fatty acids in human adults
Burdge, G. C., & Calder, P. C. (2005) · Reproduction Nutrition Development · doi:10.1051/rnd:2005047 · Cited by 939
Metabolism of highly unsaturated n-3 and n-6 fatty acids
Sprecher, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 868
Burdge, G. C., & Wootton, S. A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002689 · Cited by 812
Gebauer, S. K., Psota, T. L., Harris, W. S., & Kris-Etherton, P. M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1526s · Cited by 642
Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man
Brenna, J. T. (2002) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200203000-00002 · Cited by 512
Metabolism and functional effects of plant-derived omega-3 fatty acids in humans
Baker, E. J., Miles, E. A., Burdge, G. C., Yaqoob, P., & Calder, P. C. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.07.002 · Cited by 472
??-Linolenic acid metabolism in men and women: nutritional and biological implications
Burdge, G. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200403000-00006 · Cited by 426
Metadata
- Authors
- Yuan, Q., Xie, F., Huang, W., Hu, M., Yan, Q., Chen, Z., Zheng, Y., & Liu, L.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2021-09-22
- Volume
- 36
- Issue
- 1
- Pages
- 164-188
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W3201094218
- Cited by
- 285
- References
- 191
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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