The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

The American journal of clinical nutrition

(1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)92305-h · Cited by 3,324

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Horton, J. D., Shah, N. A., Warrington, J. A., Anderson, N. N., Park, S. W., Brown, M. S., & Goldstein, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534923100 · Cited by 1,270

Conversion of α -linolenic acid to longer-chain polyunsaturated fatty acids in human adults

Burdge, G. C., & Calder, P. C. (2005) · Reproduction Nutrition Development · doi:10.1051/rnd:2005047 · Cited by 939

Metabolism of highly unsaturated n-3 and n-6 fatty acids

Sprecher, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 868

Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women

Burdge, G. C., & Wootton, S. A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002689 · Cited by 812

n-3 Fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits.

Gebauer, S. K., Psota, T. L., Harris, W. S., & Kris-Etherton, P. M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1526s · Cited by 642

Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man

Brenna, J. T. (2002) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200203000-00002 · Cited by 512

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker, E. J., Miles, E. A., Burdge, G. C., Yaqoob, P., & Calder, P. C. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.07.002 · Cited by 472

??-Linolenic acid metabolism in men and women: nutritional and biological implications

Burdge, G. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200403000-00006 · Cited by 426

FATTY ACIDS AS BIOCOMPOUNDS: THEIR ROLE IN HUMAN METABOLISM, HEALTH AND DISEASE - A REVIEW. PART 1: CLASSIFICATION, DIETARY SOURCES AND BIOLOGICAL FUNCTIONS

Tvrzicka, E., Kremmyda, L.-S., Stankova, B., & Zak, A. (2011) · Biomedical Papers · doi:10.5507/bp.2011.038 · Cited by 407

Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances

Lee, J., Lee, H., Kang, S., & Park, W. (2016) · Nutrients · doi:10.3390/nu8010023 · Cited by 398

Metabolism of α-linolenic acid in humans

Burdge, G. C. (2006) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.05.013 · Cited by 388

Long-chain conversion of [13C]linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men

Hussein, N., Ah-Sing, E., Wilkinson, P., Leach, C., Griffin, B. A., & Millward, D. J. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400225-jlr200 · Cited by 371

α-Linolenic acid: Nutraceutical, pharmacological and toxicological evaluation

Kim, K.-B., Nam, Y. A., Kim, H. S., Hayes, A. W., & Lee, B.-M. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.05.009 · Cited by 314

Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial

Bloedon, L. T., Balikai, S., Chittams, J., Cunnane, S. C., Berlin, J. A., Rader, D. J., & Szapary, P. O. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719676 · Cited by 253

Plant- and marine-derived n−3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects

Finnegan, Y. E., Minihane, A. M., Leigh-Firbank, E. C., Kew, S., Meijer, G. W., Muggli, R., Calder, P. C., & Williams, C. M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.783 · Cited by 246

Flaxseed and Cardiovascular Risk

Bloedon, L. T., & Szapary, P. O. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00002.x · Cited by 198

Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats

Poudyal, H., Panchal, S. K., Waanders, J., Ward, L., & Brown, L. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.11.011 · Cited by 187

Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats

Vijaimohan, K., Jainu, M., Sabitha, K. E., Subramaniyam, S., Anandhan, C., & Shyamala Devi, C. S. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.025 · Cited by 186

Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Sala‐Vila, A., Guasch‐Ferré, M., Hu, F. B., Sánchez‐Tainta, A., Bulló, M., Serra‐Mir, M., López‐Sabater, C., Sorlí, J. V., Arós, F., Fiol, M., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002543 · Cited by 178

An α-Linolenic Acid-Rich Formula Reduces Oxidative Stress and Inflammation by Regulating NF-κB in Rats with TNBS-Induced Colitis ,

Hassan, A., Ibrahim, A., Mbodji, K., Coëffier, M., Ziegler, F., Bounoure, F., Chardigny, J.-M., Skiba, M., Savoye, G., Déchelotte, P., et al. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119768 · Cited by 177

Dietary chia seed (Salvia hispanica L.) rich in α-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats

Chicco, A. G., D'Alessandro, M. E., Hein, G. J., Oliva, M. E., & Lombardo, Y. B. (2008) · British Journal of Nutrition · doi:10.1017/s000711450899053x · Cited by 171

Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones—Microbiota—Inflammation Axis in Rats

Wang, T., Sha, L., Li, Y., Zhu, L., Wang, Z., Li, K., Lu, H., Bao, T., Guo, L., Zhang, X., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00284 · Cited by 162

Anti-inflammatory effects of α-linolenic acid in M1-like macrophages are associated with enhanced production of oxylipins from α-linolenic and linoleic acid

Pauls, S. D., Rodway, L. A., Winter, T., Taylor, C. G., Zahradka, P. C., & Aukema, H. M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.020 · Cited by 155

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Blondeau, N., Nguemeni, C., Debruyne, D. N., Piens, M., Wu, X., Pan, H., Hu, X., Gandin, C., Lipsky, R. H., Plumier, J.-C., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.84 · Cited by 154

α-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction

Campos, H., Baylín, A., & Willett, W. C. (2008) · Circulation · doi:10.1161/circulationaha.107.762419 · Cited by 153

Bioavailability of Alpha-Linolenic Acid in Subjects after Ingestion of Three Different Forms of Flaxseed

Austria, J. A., Richard, M. N., Chahine, M. N., Edel, A. L., Malcolmson, L., Dupasquier, C. M. C., & Pierce, G. N. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719693 · Cited by 151

Understanding omega-3's

DeFilippis, A. P., & Sperling, L. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.03.051 · Cited by 150

The Majority of Dietary Linoleate in Growing Rats is β-Oxidized or Stored in Visceral Fat ,

Cunnane, S. C., & Anderson, M. J. (1997) · Journal of Nutrition · doi:10.1093/jn/127.1.146 · Cited by 144

Flaxseed Consumption Reduces Blood Pressure in Patients With Hypertension by Altering Circulating Oxylipins via an α-Linolenic Acid–Induced Inhibition of Soluble Epoxide Hydrolase

Caligiuri, S. P. B., Aukema, H. M., Ravandi, A., Guzman, R., Dibrov, E., & Pierce, G. N. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03179 · Cited by 144

Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial

Dodin, S., Cunnane, S. C., Mâsse, B., Lemay, A., Jacques, H., Asselin, G., Tremblay-Mercier, J., Marc, I., Lamarche, B., Légaré, F., et al. (2008) · Nutrition · doi:10.1016/j.nut.2007.09.003 · Cited by 142

Sheep cheese naturally enriched in α-linolenic, conjugated linoleic and vaccenic acids improves the lipid profile and reduces anandamide in the plasma of hypercholesterolaemic subjects

Pintus, S., Murru, E., Carta, G., Cordeddu, L., Batetta, B., Accossu, S., Pistis, D., Uda, S., Ghiani, M. E., Mele, M. L., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003224 · Cited by 138

Effects and mechanisms of edible and medicinal plants on obesity: an updated review

Shang, A., Gan, R., Xu, X., Mao, Q., Zhang, P., & Li, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1769548 · Cited by 130

The Evidence for α-Linolenic Acid and Cardiovascular Disease Benefits: Comparisons with Eicosapentaenoic Acid and Docosahexaenoic Acid

Fleming, J. A., & Kris‐Etherton, P. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.005850 · Cited by 125

Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet

Gao, X., Chang, S., Liu, S., Peng, L., Xie, J., Dong, W., Tian, Y., & Sheng, J. (2020) · mSystems · doi:10.1128/msystems.00391-20 · Cited by 125

α-Linolenic acid (ALA) is an anti-inflammatory agent in inflammatory bowel disease

Reifen, R. M., Karlinsky, A., Stark, A. H., Berkovich, Z., & Nyska, A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.006 · Cited by 122

Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid

Zatonski, W., Campos, H., & Willett, W. (2008) · European Journal of Epidemiology · doi:10.1007/s10654-007-9195-1 · Cited by 119

Anti-Inflammatory Effects of Alpha Linolenic Acid on Human Corneal Epithelial Cells

Erdinest, N., Shmueli, O., Grossman, Y., Ovadia, H., & Solomon, A. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9724 · Cited by 116

Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats

Rincón‐Cervera, M. Á., Valenzuela, R., Hernández‐Rodas, M. C., Barrera, C. R., Espinosa, A., Marambio, M., & Valenzuela, A. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.02.002 · Cited by 113

Elevated Production of Docosahexaenoic Acid in Females: Potential Molecular Mechanisms

Kitson, A. P., Stroud, C. K., & Stark, K. D. (2010) · Lipids · doi:10.1007/s11745-010-3391-6 · Cited by 106

Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke

Nguemeni, C., Delplanque, B., Rovère, C., Simon-Rousseau, N., Gandin, C., Agnani, G., Nahon, J., Heurteaux, C., & Blondeau, N. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.007 · Cited by 105

α‐Linolenic acid‐derived metabolites from gut lactic acid bacteria induce differentiation of anti‐inflammatory M2 macrophages through G protein‐coupled receptor 40

Ohue‐Kitano, R., Watanabe‐Yasuoka, Y., Goto, T., Kitamura, N., Park, S., Kishino, S., Kimura, I., Kasubuchi, M., Takahashi, H., Li, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700273r · Cited by 105

α-Linolenic acid in health and disease

Connor, W. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.827 · Cited by 103

α‐Linolenic acid metabolism in adult humans: the effects of gender and age on conversion to longer‐chain polyunsaturated fatty acids

Burdge, G. C., & Calder, P. C. (2005) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200501145 · Cited by 103

Linoleic acid, α-linolenic acid, and monolinolenins as antibacterial substances in the heat-processed soybean fermented with Rhizopus oligosporus

Kusumah, D., Wakui, M., Mai, M., Xie, X., Kabuyama, Y., & Maeda, I. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1731299 · Cited by 103

Diets containing α-linolenic (ω3) or oleic (ω9) fatty acids rescues obese mice from insulin resistance

Oliveira, V., Marinho, R., Vitorino, D., Santos, G. A., Moraes, J. C., Dragano, N., Sartori-Cintra, A., Pereira, L., Catharino, R. R., da Silva, A. S. R., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1880 · Cited by 102 · cited 2×

Whole body distribution of deuterated linoleic and α-linolenic acids and their metabolites in the rat

Lin, Y. H., & Salem, N. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700369-jlr200 · Cited by 95

Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome

Baxheinrich, A., Stratmann, B., Lee-Barkey, Y. H., Tschoepe, D., & Wahrburg, U. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002875 · Cited by 92

Effects of α-linolenic acid intake on blood lipid profiles：a systematic review and meta-analysis of randomized controlled trials

Yue, H., Qiu, B., Jia, M., Liu, W., Guo, X., Li, N., Xu, Z., Du, F., Xu, T., & Li, D. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1790496 · Cited by 92

Flaxseed Oil Supplementation Does Not Affect Plasma Lipoprotein Concentration or Particle Size in Human Subjects

Harper, C. R., Edwards, M. C., & Jacobson, T. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.11.2844 · Cited by 90

Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

Burns, R. N., & Moniri, N. H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.057 · Cited by 89

Dietary α-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation

Holy, E. W., Forestier, M., Richter, E. K., Akhmedov, A., Leiber, F., Camici, G. G., Mocharla, P., Lüscher, T. F., Beer, J. H., & Tanner, F. C. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.226118 · Cited by 88

The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary

Wood, K., Mantzioris, E., Gibson, R. A., Ramsden, C. E., & Mühlhäusler, B. S. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.01.001 · Cited by 88

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Winnik, S. H., Lohmann, C., Richter, E., Schäfer, N., Song, W., Leiber, F., Mocharla, P., Hofmann, J., Klingenberg, R., Borén, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq501 · Cited by 81

Vegetable lipids as components of functional foods.

Stuchlík, M., & Žák, S. (2002) · Biomedical Papers · doi:10.5507/bp.2002.001 · Cited by 81

Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs

Smink, W., Gerrits, W. J. J., Gloaguen, M., Ruiter, A., & van Baal, J. (2012) · animal · doi:10.1017/s1751731111001479 · Cited by 80

Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study

Djoussé, L., Hunt, S. C., Arnett, D. K., Province, M. A., Eckfeldt, J. H., & Ellison, R. C. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1098 · Cited by 80

Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice

Wang, M., Zhang, X., Feng, K., He, C., Li, P., Yuanjia, H., Su, H., & Wan, J. (2016) · Scientific Reports · doi:10.1038/srep26826 · Cited by 80

Reduced acute neuroinflammation and improved functional recovery after traumatic brain injury by α-linolenic acid supplementation in mice

Desai, A., Park, T., Barnes, J., Kevala, K., Chen, H., & Kim, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0714-4 · Cited by 77

The effect of alpha-linolenic acid on glycemic control in individuals with type 2 diabetes: A systematic review and meta-analysis of randomized controlled clinical trials

Jovanovski, E., Li, D., Ho, H. V. T., Djedovic, V., Marques, A. D. C. R., Shishtar, E., Mejía, S. B., Sievenpiper, J. L., de Souza, R. J., Duvnjak, L. S., et al. (2017) · Medicine · doi:10.1097/md.0000000000006531 · Cited by 77

α-Linolenic Acid Intake Attenuates Myocardial Ischemia/Reperfusion Injury through Anti-inflammatory and Anti-oxidative Stress Effects in Diabetic But Not Normal Rats

Xie, N., Zhang, W., Li, J., Liang, H., Zhou, H., Duan, W., Xu, X., Yu, S., Zhang, H., & Yi, D. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.04.008 · Cited by 76

Alpha-linolenic acid protects against lipopolysaccharide-induced acute lung injury through anti-inflammatory and anti-oxidative pathways

Zhu, X., Wang, B., Zhang, X., Chen, X., Zhu, J., Zou, Y., & Li, J. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104077 · Cited by 74

Cloning and functional characterisation of a fatty acyl elongase from southern bluefin tuna (Thunnus maccoyii)

Gregory, M. K., See, V. H. L., Gibson, R. A., & Schuller, K. A. (2009) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2009.11.002 · Cited by 71

Effects of a 12-week high-α-linolenic acid intervention on EPA and DHA concentrations in red blood cells and plasma oxylipin pattern in subjects with a low EPA and DHA status

Greupner, T., Kutzner, L., Nolte, F., Strangmann, A., Kohrs, H., Hahn, A., Schebb, N. H., & Schuchardt, J. P. (2018) · Food & Function · doi:10.1039/c7fo01809f · Cited by 70

Substitution of linoleic acid with α-linolenic acid or long chain n-3 polyunsaturated fatty acid prevents Western diet induced nonalcoholic steatohepatitis

Jeyapal, S., Kona, S. R., Mullapudi, S. V., Putcha, U. K., Gurumurthy, P., & Ibrahim, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29222-y · Cited by 70

Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension.

Singer, P., Jaeger, W., Berger, I., Barleben, H., Wirth, M., Richter-Heinrich, E., Voigt, S., & Gödicke, W. (1990) · PubMed · Cited by 69

Research Communication: Plant and Marine Derived (n-3) Polyunsaturated Fatty Acids Do Not Affect Blood Coagulation and Fibrinolytic Factors in Moderately Hyperlipidemic Humans

Finnegan, Y. E., Minihane, A. M., Williams, C. M., Howarth, D., Kew, S., Miller, G. J., & Calder, P. C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2210 · Cited by 68

Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats

Oliva, M. E., Ferreira, M. D. R., Chicco, A. G., & Lombardo, Y. B. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.010 · Cited by 68

High Dose Flaxseed Oil Supplementation May Affect Fasting Blood Serum Glucose Management in Human Type 2 Diabetics

Barre, D. E., Mizier-Barre, K. A., Griscti, O., & Hafez, K. K. (2008) · Journal of Oleo Science · doi:10.5650/jos.57.269 · Cited by 68

Alpha-Linolenic Acid Intake and 10-Year Incidence of Coronary Heart Disease and Stroke in 20,000 Middle-Aged Men and Women in The Netherlands

de Goede, J., Verschuren, W. M. M., Boer, J. M. A., Kromhout, D., & Geleijnse, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017967 · Cited by 68

α-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress

Katsoulieris, E. N., Mabley, J. G., Samai, M. H., Green, I. C., & Chatterjee, P. K. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.09.015 · Cited by 67

Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Umesha, S. S., & Naidu, K. A. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.05.118 · Cited by 66

Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes

Gomes, P. M., Miranda, W. R. D. H., Beraldo, R. A., Castro, A. V., Geloneze, B., Foss, M. C., & Foss‐Freitas, M. C. (2015) · Nutrition · doi:10.1016/j.nut.2014.12.028 · Cited by 64

Enhancing LC-PUFA production in Thalassiosira pseudonana by overexpressing the endogenous fatty acid elongase genes

Cook, O., & Hildebrand, M. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0617-2 · Cited by 64

α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes

Zhang, Y., Dong, L., Yang, X., Shi, H., & Zhang, L. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-81 · Cited by 63

Hypolipidemic Activity of Peony Seed Oil Rich in α-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid β-Oxidation

Su, J., Ma, C., Liu, C., Gao, C., Nie, R., & Wang, H. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13252 · Cited by 62

Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa

Hoffman, D. R., DeMar, J. C., Heird, W. C., Birch, D. G., & Anderson, R. E. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30271-6 · Cited by 62

Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells

Moon, H., Batırel, S., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.009 · Cited by 61

Effect of dietary alpha-linolenic acid on blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials

Su, H., Liu, R., Chang, M., Huang, J., Jin, Q., & Wang, X. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1386-2 · Cited by 61

The Alpha Linolenic Acid Content of Flaxseed is Associated with an Induction of Adipose Leptin Expression

McCullough, R. S., Edel, A. L., Bassett, C. M. C., LaVallee, R., Dibrov, E., Blackwood, D. P., Ander, B. P., & Pierce, G. N. (2011) · Lipids · doi:10.1007/s11745-011-3619-0 · Cited by 60

Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat

Pal, M., & Ghosh, M. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.12.042 · Cited by 60

Effects of an energy-restricted diet rich in plant-derived α-linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits

Egert, S., Baxheinrich, A., Lee-Barkey, Y. H., Tschoepe, D., Wahrburg, U., & Stratmann, B. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002001 · Cited by 59

Anti-inflammatory Potential of Alpha-Linolenic Acid Mediated Through Selective COX Inhibition: Computational and Experimental Data

Anand, R., & Kaithwas, G. (2014) · Inflammation · doi:10.1007/s10753-014-9857-6 · Cited by 57

Increased dietary α-linolenic acid has sex-specific effects upon eicosapentaenoic acid status in humans: re-examination of data from a randomised, placebo-controlled, parallel study

Childs, C. E., Kew, S., Finnegan, Y. E., Minihane, A. M., Leigh-Firbank, E. C., Williams, C. M., & Calder, P. C. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-113 · Cited by 56

The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat

Bassett, C. M. C., McCullough, R. S., Edel, A. L., Patenaude, A. F., LaVallee, R., & Pierce, G. N. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00958.2010 · Cited by 55

α-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation

Fan, R., Kim, J., You, M., Giraud, D., Toney, A. M., Shin, S. H., Kim, S., Borkowski, K., Newman, J. W. I., & Chung, S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108285 · Cited by 55

α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux

Li, G., Wang, X., Yang, H., Zhang, P., Wu, F., Li, Y., Zhou, Y., Xing, Z., Ma, H., Zhang, W., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2277-7 · Cited by 55

Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds

Yang, Q., Cao, W., Zhou, X., Cao, W., Xie, Y., & Wang, S. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-348 · Cited by 54

Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes

Zhang, Y., Yang, X., Shi, H., Dong, L., & Bai, J. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-122 · Cited by 53

α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression

Fukumitsu, S., Villareal, M. O., Onaga, S., Aida, K., Han, J., & Isoda, H. (2012) · Cytotechnology · doi:10.1007/s10616-012-9510-x · Cited by 52

The association and dose–response relationship between dietary intake of α-linolenic acid and risk of CHD: a systematic review and meta-analysis of cohort studies

Wei, J., Hou, R., Xi, Y., Kowalski, A. J., Wang, T., Yu, Z., Hu, Y., Chandrasekar, E. K., Sun, H., & Ali, M. K. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003294 · Cited by 52

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

Cândido, C. J., Figueiredo, P. S., Silva, R. D. C., Portugal, L. C., Jaques, J. A. D. S., de Almeida, J. A., Penteado, B. D. B., Dias, D. A., Marcelino, G., Pott, A., et al. (2019) · Nutrients · doi:10.3390/nu12010009 · Cited by 52

Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils

Gonzalez‐Mañán, D., Tapia, G., Gormaz, J. G., D’Espessailles, A., Espinosa, A., Masson, L., Varela, P., Valenzuela, A., & Valenzuela, R. (2012) · Food & Function · doi:10.1039/c2fo30012e · Cited by 49

Dietary supplementation of α-linolenic acid induced conversion of n-3 LCPUFAs and reduced prostate cancer growth in a mouse model

Li, J., Gu, Z., Pan, Y., Wang, S., Chen, H., Zhang, H., Chen, W., & Chen, Y. Q. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0529-z · Cited by 49

Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology

Pan, H., Hu, X., Jacobowitz, D. M., Chen, C., McDonough, J. H., Shura, K. E. V., Lyman, M. E., & Marini, A. M. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.07.001 · Cited by 48

Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke

Bourourou, M., Heurteaux, C., & Blondeau, N. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.040 · Cited by 47

Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats

Matravadia, S., Herbst, E. A. F., Jain, S. S., Mutch, D. M., & Holloway, G. P. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00032.2014 · Cited by 46

A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats

Hanke, D., Zahradka, P. C., Mohankumar, S. K., Clark, J. L., & Taylor, C. G. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.009 · Cited by 46

α-linolenic acid inhibits human renal cell carcinoma cell proliferation through PPAR-γ activation and COX-2 inhibition

Yang, L., Yuan, J., Liu, L., Shi, C., Wang, L., Tian, F., Liu, F., Wang, H., Shao, C., Zhang, Q., et al. (2013) · Oncology Letters · doi:10.3892/ol.2013.1336 · Cited by 46

α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition

Wang, S., Sun, H., Hsu, Y., Liu, S., Lii, C., Tsai, C.-H., Liu, K., Huang, C., & Li, C. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114152 · Cited by 46

The effect of flaxseed dose on circulating concentrations of alpha-linolenic acid and secoisolariciresinol diglucoside derived enterolignans in young, healthy adults

Edel, A. L., Patenaude, A. F., Richard, M. N., Dibrov, E., Austria, J. A., Aukema, H. M., Pierce, G. N., & Aliani, M. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0885-2 · Cited by 45

Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action

Zhang, J., Kris‐Etherton, P. M., Thompson, J. T., Hannon, D. B., Gillies, P. J., & Heuvel, J. P. V. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.01.004 · Cited by 45

Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans

Hadjighassem, M., Kamalıdehghan, B., Shekarriz, N., Baseerat, A., Molavi, N., Mehrpour, M., Joghataei, M. T., Tondar, M., Ahmadipour, F., & Meng, G. Y. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0012-5 · Cited by 45

Alpha-Linolenic Acid fromPerilla frutescensvar.japonicaOil Protects Aβ-Induced Cognitive Impairment through Regulation of APP Processing and Aβ Degradation

Lee, A. Y., Lee, M. H., Lee, S., & Cho, E. J. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03941 · Cited by 45

Essential Fatty Acids Linoleic Acid and α‐Linolenic Acid Sex‐Dependently Regulate Glucose Homeostasis in Obesity

Zhuang, P., Shou, Q., Wang, W., He, L., Wang, J., Chen, J., Zhang, Y., & Jiao, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800448 · Cited by 45

Effect of α-linolenic acid on vascular function and metabolic risk markers during the fasting and postprandial phase: A randomized placebo-controlled trial in untreated (pre-)hypertensive individuals

Joris, P. J., Draijer, R., Fuchs, D., & Mensink, R. P. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.032 · Cited by 45

Effect of alpha-linolenic acid in combination with the flavonol quercetin on markers of cardiovascular disease risk in healthy, non-obese adults: A randomized, double-blinded placebo-controlled crossover trial

Burak, C., Wolffram, S., Zur, B., Langguth, P., Fimmers, R., Alteheld, B., Stehle, P., & Egert, S. (2018) · Nutrition · doi:10.1016/j.nut.2018.06.012 · Cited by 44

Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse

Monteiro, J., Askarian, F., Nakamura, M., Moghadasian, M. H., & David, W. L. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0308 · Cited by 43

Neuroprotective Effect of Alpha-Linolenic Acid against Aβ-Mediated Inflammatory Responses in C6 Glial Cell

Lee, A. Y., Lee, M. H., Lee, S., & Cho, E. J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00836 · Cited by 43

Low-linoleic acid diet and oestrogen enhance the conversion ofα-linolenic acid into DHA through modification of conversion enzymes and transcription factors

Kim, D., Choi, J.-E., & Park, Y. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518003252 · Cited by 43

α-Linolenic Acid-Rich Diet Influences Microbiota Composition and Villus Morphology of the Mouse Small Intestine

Todorov, H., Kollar, B., Bayer, F., Brandão, I., Mann, A., Mohr, J., Pontarollo, G., Formes, H., Stauber, R. H., Kittner, J. M., et al. (2020) · Nutrients · doi:10.3390/nu12030732 · Cited by 43

Prostatic Alpha-Linolenic Acid (ALA) Is Positively Associated with Aggressive Prostate Cancer: A Relationship Which May Depend on Genetic Variation in ALA Metabolism

Azrad, M., Zhang, K., Vollmer, R. T., Madden, J. F., Polascik, T. J., Snyder, D. C., Ruffin, M. T., Moul, J. W., Brenner, D. E., Hardy, R. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053104 · Cited by 42

Alpha-linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expression in human cervical cancer cell lines

Deshpande, R., Mansara, P., & Kaul-Ghanekar, R. (2015) · Tumor Biology · doi:10.1007/s13277-015-4170-z · Cited by 41

Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats

Gao, H. Y., Yan, P., Zhang, S., Huang, H., Huang, F., Sun, T., Deng, Q., Huang, Q., Chen, S., Ye, K., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9393-x · Cited by 41

Maternal α‐linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring

Niculescu, M. D., Lupu, D. S., & Craciunescu, C. N. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.09.006 · Cited by 41

Alpha‐linolenic acid given as an anti‐inflammatory agent in a mouse model of colonic inflammation

Wen, J., KHAN, I. A., Li, A., Chen, X., Yang, P., Song, P., Jing, Y., Wei, J., Che, T., & Zhang, C. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1225 · Cited by 41

Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source

Begg, D. P., Sinclair, A. J., Stahl, L., Premaratna, S. D., Ahmad, H., Jois, M., & Weisinger, R. S. (2010) · Hypertension Research · doi:10.1038/hr.2010.84 · Cited by 40

Effects of a low and a high dietary LA/ALA ratio on long-chain PUFA concentrations in red blood cells

Greupner, T., Kutzner, L., Pagenkopf, S., Kohrs, H., Hahn, A., Schebb, N. H., & Schuchardt, J. P. (2018) · Food & Function · doi:10.1039/c8fo00735g · Cited by 40

Linolenic Acid Transport in Hamster Intestinal Cells Is Carrier-Mediated

Goré, J., & Hoinard, C. (1993) · Journal of Nutrition · doi:10.1093/jn/123.1.66 · Cited by 39

α-Linolenic Acid-Enriched Cold-Pressed Perilla Oil Suppress High-Fat Diet-Induced Hepatic Steatosis through Amelioration of the ER Stress-Mediated Autophagy

Bae, S. J., Kim, J. E., Choi, H. J., Choi, Y. J., Lee, S. J., Gong, J. E., Seo, S., Yang, S. Y., An, B., Lee, H. S., et al. (2020) · Molecules · doi:10.3390/molecules25112662 · Cited by 39

Dietary {alpha}-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Winnik, S. H., Lohmann, C., Richter, E., Schäfer, N., Song, W.-M., Leiber, F., Mocharla, P. S., Hofmann, J., Klingenberg, R., Borén, J., et al. (2011) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-44655 · Cited by 38

Flaxseed Oil Containingα-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Han, H., Yan, P., Chen, L., Luo, C., Gao, H. Y., Deng, Q., Zheng, M., Shi, Y., & Liu, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/958217 · Cited by 37

Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults

Heskey, C. E., Jaceldo‐Siegl, K., Sabaté, J., Fraser, G. E., & Rajaram, S. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118935 · Cited by 36

α-Linolenic acid prevents hepatic steatosis and improves glucose tolerance in mice fed a high-fat diet

Gonçalves, N. B., Bannitz, R. F., da Silva, B. R., Becari, D. D., Poloni, C., Gomes, P. M., Foss, M. C., & Foss‐Freitas, M. C. (2018) · Clinics · doi:10.6061/clinics/2018/e150 · Cited by 36

Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells

Wiggins, A. K. A., Mason, J. K., & Thompson, L. U. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.020 · Cited by 35

α-Linolenic Acid Inhibits Receptor Activator of NF-κB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-κB-iNOS) Signaling Pathways

Song, J., Jing, Z., Hu, W. M., Yu, J., & Cui, X. (2017) · Medical Science Monitor · doi:10.12659/msm.904795 · Cited by 35

The Effects of Alpha-Linolenic Acid on the Secretory Activity of Astrocytes and β Amyloid-Associated Neurodegeneration in Differentiated SH-SY5Y Cells: Alpha-Linolenic Acid Protects the SH-SY5Y cells against β Amyloid Toxicity

Litwiniuk, A., Domańska, A., Chmielowska, M., Martyńska, L., Bik, W., & Kalisz, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8908901 · Cited by 35

AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid

Zhou, X., Wu, W.-C., Chen, J., Wang, X., & Wang, Y. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0006-5 · Cited by 34

Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway

Gao, H. Y., Yan, P., Zhang, S., Nie, S., Huang, F., Han, H., Deng, Q., Huang, Q., Yang, W. Q., Wu, H., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.012 · Cited by 34

Characterization of a New α‐Linolenic Acid‐Rich Oil: Eucommia ulmoides Seed Oil

Zhang, Z., Liu, Y., & Che, L. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14049 · Cited by 34

α-Linolenic Acid Reduces Growth of Both Triple Negative and Luminal Breast Cancer Cells in High and Low Estrogen Environments

Wiggins, A. K. A., Kharotia, S., Mason, J. K., & Thompson, L. U. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1053496 · Cited by 33

α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology

Piermartiri, T., Pan, H., Figueiredo, T. H., & Marini, A. M. (2015) · Molecules · doi:10.3390/molecules201119698 · Cited by 33

Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice

Wang, M., Zhang, X., Yan, C., He, C., Li, P., Chen, M., Su, H., & Wan, J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.012 · Cited by 33

Dietary α-linolenic acid–rich formula reduces adhesion molecules in rats with experimental colitis

Ibrahim, A. B., Aziz, M., Hassan, A., Mbodji, K., Colasse, É., Coëffier, M., Bounoure, F., Savoye, G., Déchelotte, P., & Marion‐Letellier, R. (2012) · Nutrition · doi:10.1016/j.nut.2011.10.008 · Cited by 32

Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome

Egert, S., Baxheinrich, A., Lee-Barkey, Y. H., Tschoepe, D., Stehle, P., Stratmann, B., & Wahrburg, U. (2017) · Nutrition · doi:10.1016/j.nut.2017.11.002 · Cited by 32

Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide

Lee, A. Y., Choi, J. M., Lee, M. H., Lee, J., Lee, S., & Cho, E. J. (2018) · Nutrition Research and Practice · doi:10.4162/nrp.2018.12.2.93 · Cited by 32

Linoleic and α-linolenic fatty acid consumption over three generations exert cumulative regulation of hepatic expression of genes related to lipid metabolism

Jacometo, C. B., Schmitt, E., Pfeifer, L. F. M., Schneider, A., Bado, F., da Rosa, F. T., Halfen, S., Pino, F. A. B. D., Loor, J. J., Corrêa, M. N., et al. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0405-7 · Cited by 31

Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva

Kumari, S., Mazumder, A. G., Bhardwaj, A., & Singh, D. (2019) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2019.02.002 · Cited by 31

Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo

Shen, J., Ma, Q., Shen, S., Xu, G., & Das, U. N. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.09.010 · Cited by 30

Alpha-Linolenic Acid Exerts an Endothelial Protective Effect against High Glucose Injury via PI3K/Akt Pathway

Zhang, W., Li, R., Li, J., Wang, W., Tie, R., Tian, F., Liang, X., Xing, W., He, Y., Yu, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068489 · Cited by 30

Uptake of α‐Linolenic Acid and Its Conversion to Long Chain Omega‐3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil

Dhavamani, S., & Lokesh, B. R. (2012) · Lipids · doi:10.1007/s11745-012-3731-9 · Cited by 30

Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning

Shomonov-Wagner, L., Raz, A., & Leikin-Frenkel, A. I. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0012-7 · Cited by 30

Effect of ALA‐Enriched Food Supply on Cardiovascular Risk Factors in Males

Sioen, I., Hacquebard, M., Hick, G., Maindiaux, V., Larondelle, Y., Carpentier, Y., & Henauw, S. D. (2009) · Lipids · doi:10.1007/s11745-009-3307-5 · Cited by 28

The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special Turku Coronary Risk Factor Intervention Project Study

Skilton, M. R., Pahkala, K., Viikari, J. S. A., Rönnemaa, T., Simell, O., Jula, A., Niinikoski, H., Celermajer, D. S., & Raitakari, O. T. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.01.020 · Cited by 28

Synergism of α‐Linolenic Acid, Conjugated Linoleic Acid and Calcium in Decreasing Adipocyte and Increasing Osteoblast Cell Growth

Kim, Y. J., Kelly, O. J., & Ilich, J. Z. (2013) · Lipids · doi:10.1007/s11745-013-3803-5 · Cited by 28

Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring’s Anxious Behavior with a Sex-Dependent Manner in Mice

Sakayori, N., Tokuda, H., Yoshizaki, K., Kawashima, H., Innis, S. M., Shibata, H., & Osumi, N. (2016) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.240.31 · Cited by 27

Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity

Miyazawa, D., Yasui, Y., Yamada, K., Ohara, N., & Okuyama, H. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.003 · Cited by 25

Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study

Cabout, M., Alssema, M., Nijpels, G., Stehouwer, C. D. A., Zock, P. L., Brouwer, I. A., Elshorbagy, A. K., Refsum, H., & Dekker, J. M. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1261-6 · Cited by 25

Consumption of alpha-linolenic acid-enriched diacylglycerol induces increase in dietary fat oxidation compared with alpha-linolenic acid-enriched triacylglycerol: A randomized, double-blind trial

Ando, Y., Saito, S., Miura, H., Osaki, N., & Katsuragi, Y. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.10.012 · Cited by 25

Chlorambucil (nitrogen mustard) induced impairment of early vascular endothelial cell migration – Effects of α-linolenic acid and N-acetylcysteine

Steinritz, D., Schmidt, A., Simons, T., Ibrahim, M. A., Morguet, C., Balszuweit, F., Thiermann, H., Kehe, K., Bloch, W., & Bölck, B. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.05.015 · Cited by 24

Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study

Lemaître, R. N., Sitlani, C. M., Song, X., King, I. B., McKnight, B., Spiegelman, D. L., Sacks, F. M., Djoussé, L., Rimm, E. B., Siscovick, D. S., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037960 · Cited by 24

Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Kim, M., Kim, M., Lee, Y. J., Lee, S. P., Kim, T. S., Yang, H. J., Kwon, D. Y., Lee, S., & Lee, J. H. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.026 · Cited by 24

Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice

Hollander, K. S., Brami, C. T., Konikoff, F. M., FAINARU, M., & Leikin-Frenkel, A. I. (2014) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2014.940352 · Cited by 23

Lymphatic Transport of α‐Linolenic Acid and Its Conversion to Long Chain n‐3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil

Dhavamani, S., Devaraj, V. C., Mullangi, R., et al. (2013) · Lipids · doi:10.1007/s11745-013-3873-4 · Cited by 23

Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice

Canetti, L., Werner, H., & Leikin-Frenkel, A. I. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.868002 · Cited by 22

α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats

Monaco, C. M. F., Proudfoot, R., Miotto, P. M., Herbst, E. A. F., MacPherson, R. E. K., & Holloway, G. P. (2017) · Diabetologia · doi:10.1007/s00125-017-4456-3 · Cited by 22

Alpha-linolenic acid protects against cardiac injury and remodelling induced by beta-adrenergic overstimulation

Folino, A., Sprio, A. E., Scipio, F. D., Berta, G. N., & Rastaldo, R. (2015) · Food & Function · doi:10.1039/c5fo00034c · Cited by 21

Effect of Alpha Linolenic Acid Supplementation on Serum Prostate Specific Antigen (PSA): Results from the Alpha Omega Trial

Brouwer, I. A., Geleijnse, J. M., Klaasen, V. M., Smit, L. A., Giltay, E. J., de Goede, J., Heijboer, A. C., Kromhout, D., & Katan, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081519 · Cited by 20

Effect of enteral administration of α-linolenic acid and linoleic acid against methotrexate induced intestinal toxicity in albino rats

Raj, P., Singh, M., Rawat, J. K., Gautam, S., Saraf, S. A., & Kaithwas, G. (2014) · RSC Advances · doi:10.1039/c4ra10213d · Cited by 20

α-Linolenic acid increases the G0/G1 switch gene 2 mRNA expression in peripheral blood mononuclear cells from obese patients: a pilot study

Zhao, N., Wang, L., & Guo, N. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0207-6 · Cited by 20

Alpha Linolenic Acid-enriched Diacylglycerol Enhances Postprandial Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trail

Ando, Y., Saito, S., Oishi, S., Yamanaka, N., Hibi, M., Osaki, N., & Katsuragi, Y. (2016) · Journal of Oleo Science · doi:10.5650/jos.ess16064 · Cited by 20

Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies

Chen, Y., Zhao, Q., Du, G., & Xu, Y. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0512-8 · Cited by 20

Dietary α-Linolenic Acid Counters Cardioprotective Dysfunction in Diabetic Mice: Unconventional PUFA Protection

Russell, J., Griffith, T., Naghipour, S., Vider, J., Toit, E. D., Patel, H. H., Peart, J. N., & Headrick, J. (2020) · Nutrients · doi:10.3390/nu12092679 · Cited by 20

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

Piermartiri, T., Pan, H., Chen, J., McDonough, J. H., Grunberg, N. E., Apland, J. P., & Marini, A. M. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8353-y · Cited by 19

Isolation of alpha-linolenic acid from Sutherlandia frutescens and its inhibition of Mycobacterium tuberculosis’ shikimate kinase enzyme

Masoko, P., Mabusa, I. H., & Howard, R. L. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1344-1 · Cited by 18

Alpha-Linolenic Acid Treatment Reduces the Contusion and Prevents the Development of Anxiety-Like Behavior Induced by a Mild Traumatic Brain Injury in Rats

Figueiredo, T. H., Harbert, C. L., Pidoplichko, V. I., Almeida-Suhett, C. P., Pan, H., Rossetti, K., Braga, M. F. M., & Marini, A. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0732-y · Cited by 17

The effect of Portulaca oleracea and α-linolenic acid on oxidant/antioxidant biomarkers of human peripheral blood mononuclear cells

Jelodar, G., Boskabady, M.-H., Mashhadi, S. Y., Askari, V. R., & Ghorani, V. (2018) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_737_16 · Cited by 17

Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity

Istıflı, E. S., Demir, E., Kaplan, H. M., Ateş, K. E., & Doran, F. (2019) · Cytotechnology · doi:10.1007/s10616-019-00333-2 · Cited by 17

Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography

Stivala, S., Sorrentino, S., Gobbato, S., Bonetti, N. R., Camici, G. G., Lüscher, T. F., Medalia, O., & Beer, J. H. (2019) · Haematologica · doi:10.3324/haematol.2019.220988 · Cited by 17

Alpha-linolenic acid regulates amyloid precursor protein processing by mitogen-activated protein kinase pathway and neuronal apoptosis in amyloid beta-induced SH-SY5Y neuronal cells

Lee, A. Y., Lee, M.-H., Lee, S., & Cho, E. J. (2017) · Applied Biological Chemistry · doi:10.1007/s13765-017-0334-4 · Cited by 16

Alpha-linolenic acid and linoleic acid differentially regulate the skeletal muscle secretome of obese Zucker rats

Rajna, A., Gibling, H., Sarr, O., Matravadia, S., Holloway, G. P., & Mutch, D. M. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00038.2018 · Cited by 16

Perilla oil rich in α-linolenic acid suppresses hepatic SREBPs and NF-κB expression in hypercholesterolemia-induced apolipoprotein E knockout mice

Lee, J., & Song, Y. O. (2012) · Food Science and Biotechnology · doi:10.1007/s10068-012-0104-3 · Cited by 15

Supplementation with alpha-linolenic acid and inflammation: a feasibility trial

Cavina, M., Battino, M. A., Gaddi, A. V., Savo, M. T., & Visioli, F. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1802581 · Cited by 14

Beneficial impact of a mix of dairy fat with rapeseed oil on n‐6 and n‐3 PUFA metabolism in the rat: A small enrichment in dietary alpha‐linolenic acid greatly increases its conversion to DHA in the liver

Ezanno, H., Beauchamp, E., Catheline, D., Legrand, P., & Rioux, V. (2014) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201400304 · Cited by 12

Alpha-Linolenic Acid-Enriched Diacylglycerol Oil Suppresses the Postprandial Serum Triglyceride Level—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Yamanaka, N., Saito, S., Osaki, N., Sakura, K., Nakamura, H., & Katsuragi, Y. (2016) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.62.402 · Cited by 12

Evidence for the use of glomerulomegaly as a surrogate marker of glomerular damage and for alpha-linolenic acid-rich oils in the treatment of early obesity-related glomerulopathy in a diet-induced rodent model of obesity

Caligiuri, S. P. B., Blydt‐Hansen, T. D., Love, K., Grégoire, M., Taylor, C. G., Zahradka, P. C., & Aukema, H. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0476 · Cited by 11

Biphasic effect of alpha-linolenic acid on glucose-induced dysmorphogenesis and lipoperoxidation in whole rat embryo in culture

Chirino‐Galindo, G., Barrera-Argüelles, J.-I., Trejo-González, N. L., Mejía‐Zepeda, R., & Palomar-Morales, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.011 · Cited by 10

Alpha linolenic acid intake alleviates myocardial ischemia/reperfusion injury via the P2X7R/NF-κB signalling pathway

Wang, S., Liu, C., Gong, C., Li, T., Zhao, J., Xiao, W., Liu, Y., Peng, S., Xiong, C., Wang, R., et al. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.08.012 · Cited by 10

Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7)

Mason-Ennis, J. K., LeMay‐Nedjelski, L., Wiggins, A. K. A., et al. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.04.037 · Cited by 9

Effect of 1‐ and 2‐Month High‐Dose Alpha‐Linolenic Acid Treatment on 13C‐Labeled Alpha‐Linolenic Acid Incorporation and Conversion in Healthy Subjects

Pignitter, M., Lindenmeier, M., Andersen, G., Herrfurth, C., Beermann, C., Schmitt, J. J., Feußner, I., Fulda, M. S., & Somoza, V. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800271 · Cited by 9

Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice

Cao, J., Gregoire, B. R., Michelsen, K. G., & Picklo, M. J. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa044 · Cited by 9

Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat

Valenzuela, R., Barrera, C. R., Ayala, J., Julio Sanhueza, C., & Valenzuela, A. (2014) · Grasas y Aceites · doi:10.3989/gya.110113 · Cited by 8

Maternal Diet Enriched with α-Linolenic or Saturated Fatty Acids Differentially Regulates Gene Expression in the Liver of Mouse Offspring

Leikin-Frenkel, A. I., Shomonov-Wagner, L., Juknat, A., & Pasmanik‐Chor, M. (2015) · Lifestyle Genomics · doi:10.1159/000442945 · Cited by 8

Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice

Miyazawa, D., Yasui, Y., Yamada, K., Ohara, N., & Okuyama, H. (2011) · Biomedical Research · doi:10.2220/biomedres.32.237 · Cited by 7

Benefits on body fat composition of isocalorically controlled diets including functionally optimized meat products: Role of alpha-linolenic acid

Navas‐Carretero, S., San-Cristóbal, R., Avellaneda, A., Planes, J., Zulet, M. Á., & Martínez, J. A. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.005 · Cited by 7

Maternal supplementation of α-linolenic acid in normal and protein-restricted diets modulate lipid metabolism, adipose tissue growth and leptin levels in the suckling offspring

Kondreddy, V. K. R., & Naidu, K. A. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0755-3 · Cited by 7

Construction of a series of intermediates in the β-oxidation pathway from THA to EPA via DHA in free acid form

Kanamori, S., Ishida, H., Yamamoto, K., & Itoh, T. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.07.004 · Cited by 6

NO synthesis from arginine is favored by α-linolenic acid in mice fed a high-fat diet

Hermier, D., Guelzim, N., Martin, P. G. P., Huneau, J., Mathé, V., Quignard‐Boulangé, A., Lasserre, F., & Mariotti, F. (2016) · Amino Acids · doi:10.1007/s00726-016-2243-y · Cited by 5

Role of adenosine 5'-monophosphate-activated protein kinase inα-linolenic acid-induced intestinal lipid metabolism

Zhou, X., Chen, J., Wu, W.-C., Wang, X., & Wang, Y. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002391 · Cited by 4

Metabolic markers in Ossabaw pigs fed high fat diets enriched in regular or low α-linolenic acid soy oil

Potu, R. B., Lu, H., Adeola, O., & Ajuwon, K. M. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-27 · Cited by 4