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Metabonomics: the use of electrospray mass spectrometry coupled to reversed‐phase liquid chromatography shows potential for the screening of rat urine in drug development
Abstract
The application of liquid chromatography/mass spectrometry (LC/MS) followed by principal components analysis (PCA) has been successfully applied to the screening of rat urine following the administration of three candidate pharmaceuticals. With this methodology it was possible to differentiate the control samples from the dosed samples and to identify the components of the mass spectrum responsible for the separation. These data clearly show that LC/MS is a viable alternative, or complementary, technique to proton NMR for metabonomics applications in drug discovery and development. Copyright © 2002 John Wiley & Sons, Ltd.
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Citations
Cited by
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945
Cloarec, O., Dumas, M.-E., Craig, A., Barton, R. H., Trygg, J., Hudson, J., Blancher, C., Gauguier, D., Lindon, J. C., Holmes, E., et al. (2005) · Analytical Chemistry · doi:10.1021/ac048630x · Cited by 912
Large-Scale Human Metabolomics Studies: A Strategy for Data (Pre-) Processing and Validation
Bijlsma, S., Bobeldijk, I., Verheij, E. R., Ramaker, R., Kochhar, S., Macdonald, I. A., van Ommen, B., & Smilde, A. K. (2006) · Analytical Chemistry · doi:10.1021/ac051495j · Cited by 867
Gika, H. G., Theodoridis, G. A., Wingate, J. E., & Wilson, I. D. (2007) · Journal of Proteome Research · doi:10.1021/pr070183p · Cited by 502
Rochfort, S. (2005) · Journal of Natural Products · doi:10.1021/np050255w · Cited by 465
Metadata
- Authors
- Plumb, R. S., Stumpf, C. L., Gorenstein, M. V., Castro‐Perez, J. M., Dear, G. J., Anthony, M., Sweatman, B. C., Connor, S. C., & Haselden, J. N.
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 2002-09-25
- Volume
- 16
- Issue
- 20
- Pages
- 1991-1996
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W2011348557
- Cited by
- 216
- References
- 0
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Plumb, R. S., Stumpf, C. L., Gorenstein, M. V., Castro‐Perez, J. M., Dear, G. J., Anthony, M., Sweatman, B. C., Connor, S. C., & Haselden, J. N. (2002). Metabonomics: the use of electrospray mass spectrometry coupled to reversed‐phase liquid chromatography shows potential for the screening of rat urine in drug development. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
