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Nuclear Receptor Coregulators: Cellular and Molecular Biology*

McKenna, Neil J., Lanz, Rainer B., O’Malley, Bert W.·1999·Endocrine Reviews
DOI 10.1210/edrv.20.3.0366
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Abstract

Nuclear receptor coregulators are coactivators or corepressors that are required by nuclear receptors for efficient transcripitonal regulation. In this context, we define coactivators, broadly, as molecules that interact with nuclear receptors and enhance their transactivation. Analogously, we refer to nuclear receptor corepressors as factors that interact with nuclear receptors and lower the transcription rate at their target genes. Most coregulators are, by definition, rate limiting for nuclear receptor activation and repression, but do not significantly alter basal transcription. Recent data have indicated multiple modes of action of coregulators, including direct interactions with basal transcription factors and covalent modification of histones and other proteins. Reflecting this functional diversity, many coregulators exist in distinct steady state precomplexes, which are thought to associate in promoter-specific configurations. In addition, these factors may function as molecular gates to enable integration of diverse signal transduction pathways at nuclear receptor-regulated promoters. This review will summarize selected aspects of our current knowledge of the cellular and molecular biology of nuclear receptor coregulators.

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Metadata

Authors
McKenna, N. J., Lanz, R. B., & O’Malley, B. W.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1999-06-01
Volume
20
Issue
3
Pages
321-344
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.20.3.0366
OpenAlex
W2094838095
Cited by
1,911
References
10
FWCI
82.07
Type
journal article
Language
en
Open access
closed

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McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999). Nuclear Receptor Coregulators: Cellular and Molecular Biology*. Endocrine Reviews. https://doi.org/10.1210/edrv.20.3.0366

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