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Mechanisms of action of ribavirin against distinct viruses
Open accessAbstract
The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects) and direct mechanisms (interference with RNA capping, polymerase inhibition, lethal mutagenesis). Recent concerns about bioterrorism have renewed interest in exploring the antiviral activity of ribavirin against unique viruses. In this paper, we review the proposed mechanisms of action with emphasis on recent discoveries, as well as the implications of ribavirin resistance. Evidence exists to support each of the five proposed mechanisms of action, and distinct virus/host combinations may preferentially favour one or more of these mechanisms during antiviral therapy. Copyright © 2005 John Wiley & Sons, Ltd.
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Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase
Steinhauer, D. A., Domingo, E., & Holland, J. J. (1992) · Gene · doi:10.1016/0378-1119(92)90216-c · Cited by 415
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Denison, M. R., Graham, R. L., Donaldson, E. F., Eckerle, L. D., & Baric, R. S. (2011) · RNA Biology · doi:10.4161/rna.8.2.15013 · Cited by 476
IMP Dehydrogenase: Structure, Mechanism, and Inhibition
Hedstrom, L. (2009) · Chemical Reviews · doi:10.1021/cr900021w · Cited by 428
Selection for Robustness in Mutagenized RNA Viruses
Sanjuán, R., Cuevas, J. M., Furió, V., Holmes, E. C., & Moya, A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030093 · Cited by 366
Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID‐19
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Metadata
- Authors
- Graci, J. D., & Cameron, C. E.
- Venue
- Reviews in Medical Virology
- Publisher
- Wiley
- Published
- 2005-11-15
- Volume
- 16
- Issue
- 1
- Pages
- 37-48
- ISSN
- 1052-9276 (ISSN-L)
- 1099-1654
- OpenAlex
- W1975106131
- Cited by
- 549
- References
- 1
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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