The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Selection for Robustness in Mutagenized RNA Viruses
Open accessAbstract
Mutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico experiments predict that, at high mutation rates, slow-replicating genotypes can potentially outcompete faster counterparts if they benefit from a higher robustness. Here, we experimentally validate this hypothesis, dubbed the "survival of the flattest," using two populations of the vesicular stomatitis RNA virus. Characterization of fitness distributions and genetic variability indicated that one population showed a higher replication rate, whereas the other was more robust to mutation. The faster replicator outgrew its robust counterpart in standard competition assays, but the outcome was reversed in the presence of chemical mutagens. These results show that selection can directly favor mutational robustness and reveal a novel viral resistance mechanism against treatment by lethal mutagenesis.
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Cites
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Evolution of digital organisms at high mutation rates leads to survival of the flattest
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Self-citationMechanisms of action of ribavirin against distinct viruses
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Cited by
Quasispecies Theory and the Behavior of RNA Viruses
Lauring, A. S., & Andino, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001005 · Cited by 846
Spatiotemporal microbial evolution on antibiotic landscapes
Baym, M., Lieberman, T. D., Kelsic, E. D., Chait, R., Gross, R., Yelin, I., & Kishony, R. (2016) · Science · doi:10.1126/science.aag0822 · Cited by 538
Recombination within the Pandemic Norovirus GII.4 Lineage
Eden, J.-S., Tanaka, M. M., Boni, M. F., Rawlinson, W. D., & White, P. A. (2013) · Journal of Virology · doi:10.1128/jvi.03464-12 · Cited by 270
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Metadata
- Authors
- Sanjuán, R., Cuevas, J. M., Furió, V., Holmes, E. C., & Moya, A.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-06-15
- Volume
- 3
- Issue
- 6
- Pages
- e93
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1970487362
- Cited by
- 366
- References
- 43
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sanjuán, R., Cuevas, J. M., Furió, V., Holmes, E. C., & Moya, A. (2007). Selection for Robustness in Mutagenized RNA Viruses. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0030093
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
