Characterization and cytocompatibility of polydopamine on MAO‐HA coating supported on Mg‐Zn‐Ca alloy
Abstract
Magnesium has been suggested as a potential biodegradable metal for the usage as orthopaedic implants. However, high degradation rate in physiological environment remains the biggest challenge, impeding wide clinical application of magnesium‐based biomaterials. In order to reduce its degradation rate and improve the biocompatibility, micro‐arc oxidation coating doped with HA particles (MAO‐HA) was applied as the inner coating, and polydopamine (PDA) film was synthesized by dopamine self‐polymerization as the outer coating. The microstructure evolution of the coating was characterized using scanning electron microscopy (SEM), atomic force microscope (AFM), X‐ray diffraction analyses (XRD), Fourier transform infrared spectroscopy (FT‐IR), and X‐ray photoelectron spectroscopy (XPS). The results showed that PDA film had covered the entire surface of MAO‐HA coating and the pore size of MAO‐HA coating decreased. The root mean square (RMS) roughness of PDA/MAO‐HA coatings was approximately 106.46 nm, which was closer to the optimum surface roughness for cellular attachment as compared with MAO‐HA coatings. Contact angle measurement indicated that the surface wettability had been transformed from hydrophobic to hydrophilic due to the introduction of PDA. The PDA/MAO‐HA coatings exhibited better corrosion resistance in vitro, with the self‐corrosion potential increasing by 150 mV and the corrosion current density decreasing from 2.09 × 10 −5 A/cm 2 to 1.46 × 10 −6 A/cm 2 . In hydrogen…
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PDA/MAO-HA coatings have better corrosion resistance, with corrosion current density declining from 2.09 × 10−5 A/cm2 to 1.46 × 10−6 A/cm2.
“In vitro experiments showed that the PDA/MAO-HA coatings revealed better corrosion resistance, with the corrosion current density declining from 2.09 × 10−5 A/cm2 to 1.46 × 10−6 A/cm2.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [56]
PDA/MAO-HA coating exhibits good biocompatibility with increased cell proliferation (~1.2-fold at day 5) and cell adhesion properties.
“The cell-surface interaction experiment showed that the PDA/MAO-HA coating exhibited good biocompatibility with increased cell proliferation (~1.2-fold at day 5), and cell adhesion properties as seen by scanning electron microscopy.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [56]
The water contact angle of MAO-HA coating is 100.5°, while that of PDA/MAO-HA coating is 80.1°.
“The water contact angle of MAO-HA coating is measured to be 100.5°, while that of PDA/MAO-HA coating is 80.1°, which indicates that the addition of PDA has shifted the surface wettability from hydrophobic to hydrophilic.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [56]
Addition of PDA coating transforms the surface wettability of MAO-HA from hydrophobic to hydrophilic.
“The key outcome was that the addition of PDA coating transformed the surface wettability from hydrophobic to hydrophilic.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [56]
Cited by
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Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“developed a method where micro-arc oxidation coating doped with HA particles (MAO-HA) was applied as the inner coating, and the PDA film was made by DA self-polymerization as the outer coating [56].”
MethodFarshid, S., Kharaziha, M., Salehi, H., & Ganjalikhani Hakemi, M. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c11184 · Cited by 23 · see citing works
- Authors
- Feng, Y., Ma, X., Chang, L., Zhu, S., & Guan, S.
- Affiliations
- Zhengzhou University (CN)
- Helmholtz-Zentrum Hereon (DE)
- Corresponding author
- Guan, Shaokang
- Venue
- Surface and Interface Analysis
- Publisher
- Wiley
- Published
- 2017-08-14
- Volume
- 49
- Issue
- 11
- Pages
- 1115-1123
- ISSN
- 0142-2421 (ISSN-L)
- 1096-9918
- OpenAlex
- W2748923674
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 4 · 2018: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surface and Interface Analysis (publishedVersion)
- Funders
- National High Technology Research and Development Program of China (863) (2015AA033603, 2015AA020301)
- the National Key Research and Development Program of China (2016YFC1102403)
- Major Science and Technology Projects in Henan Province (141100310900)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- polydopamine coating, plasma electrolytic oxidation, hydroxyapatite, Mg-Zn-Ca alloy, corrosion resistance, surface roughness, wettability, cytocompatibility, MC3T3-E1 cells, coating microstructure
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