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An extended mixed‐effects framework for meta‐analysis

Sera, Francesco, Armstrong, Benedict, Blangiardo, Marta, Gasparrini, Antonio·2019·Statistics in Medicine

Abstract

Standard methods for meta‐analysis are limited to pooling tasks in which a single effect size is estimated from a set of independent studies. However, this setting can be too restrictive for modern meta‐analytical applications. In this contribution, we illustrate a general framework for meta‐analysis based on linear mixed‐effects models, where potentially complex patterns of effect sizes are modeled through an extended and flexible structure of fixed and random terms. This definition includes, as special cases, a variety of meta‐analytical models that have been separately proposed in the literature, such as multivariate, network, multilevel, dose‐response, and longitudinal meta‐analysis and meta‐regression. The availability of a unified framework for meta‐analysis, complemented with the implementation in a freely available and fully documented software, will provide researchers with a flexible tool for addressing nonstandard pooling problems.

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Metadata

Authors
Sera, F., Armstrong, B., Blangiardo, M., & Gasparrini, A.
Venue
Statistics in Medicine
Publisher
Wiley
Published
2019-10-24
Volume
38
Issue
29
Pages
5429-5444
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2982160553
Cited by
323
References
77
FWCI
13.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: An extended mixed‐effects framework for meta‐analysis. https://app.cochat.ai/papers/10.1002/sim.8362
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Sera, F., Armstrong, B., Blangiardo, M., & Gasparrini, A. (2019). An extended mixed‐effects framework for meta‐analysis. Statistics in Medicine. https://doi.org/10.1002/sim.8362

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