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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A hierarchical regression approach to meta‐analysis of diagnostic test accuracy evaluations

Rutter, Carolyn M., Gatsonis, Constantine A.·2001·Statistics in Medicine

Abstract

An important quality of meta‐analytic models for research synthesis is their ability to account for both within‐ and between‐study variability. Currently available meta‐analytic approaches for studies of diagnostic test accuracy work primarily within a fixed‐effects framework. In this paper we describe a hierarchical regression model for meta‐analysis of studies reporting estimates of test sensitivity and specificity. The model allows more between‐ and within‐study variability than fixed‐effect approaches, by allowing both test stringency and test accuracy to vary across studies. It is also possible to examine the effects of study specific covariates. Estimates are computed using Markov Chain Monte Carlo simulation with publicly available software (BUGS). This estimation method allows flexibility in the choice of summary statistics. We demonstrate the advantages of this modelling approach using a recently published meta‐analysis comparing three tests used to detect nodal metastasis of cervical cancer. Copyright © 2001 John Wiley & Sons, Ltd.

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Metadata

Authors
Rutter, C. M., & Gatsonis, C. A.
Venue
Statistics in Medicine
Publisher
Wiley
Published
2001-09-05
Volume
20
Issue
19
Pages
2865-2884
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2151047141
Cited by
1,505
References
2
FWCI
6.98
Type
journal article
Language
en
Open access
closed

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