Clinical applications of exosomes in cosmetic dermatology
Open accessAbstract
Introduction: Exosomes are extracellular vesicles that transport bioactive substances during normal and abnormal cellular physiological processes. The unique properties of exosomes can be exploited for use as biomarkers and targeted drug delivery vehicles, and are, for this reason, gaining increasing attention in the field of dermatology. This review aims to synthesise the existing evidence supporting exosomes in regenerative and cosmetic dermatology. Method: A comprehensive PubMed search for the period of 2010-2023 was performed using the MeSH terms "exosome" and "skin." The initial search yielded 246 studies, which were then refined to 178 studies following title and abstract screening. Studies were confined to human or animal studies published in English that evaluated the use of exosomes in medical/cosmetic dermatology. A subsequent full-text review based on these criteria yielded 34 studies, which were then reviewed. Results: Exosomes can be derived from a variety of biological sources and show potential application in wound healing, scar prophylaxis, photodamage prevention, skin regeneration, improved grafting success, hair loss mitigation, and as biomarkers and drug carriers. Conclusion: Exosomes are gaining traction in regenerative and cosmetic dermatology. However, their widespread clinical application is hindered by cost, a complex isolation process, lack of uniform protocols, limited assessment of infective potential, and a paucity of clinical evidence. Further research in this area is needed, especially by way of clinical studies evaluating the efficacy of exosome-based treatments on human skin.
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Other stem cell and platelet-EV clinical reports have demonstrated improved collagen and elasticity measures and reduced redness/texture over several weeks to months.
“Other stem cell and platelet-EV clinical reports have demonstrated improved collagen and elasticity measures and reduced redness/texture over several weeks to months, whereas our results here show that a plant-derived EV formulation can produce comparable early improvements within 28 days [26].”
Our results show that a plant-derived EV formulation can produce comparable early improvements within 28 days.
“Other stem cell and platelet-EV clinical reports have demonstrated improved collagen and elasticity measures and reduced redness/texture over several weeks to months, whereas our results here show that a plant-derived EV formulation can produce comparable early improvements within 28 days [26].”
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РАСТИТЕЛЬНЫЕ ЭКЗОСОМЫ И ИХ ПРИМЕНЕНИЕ В ЭСТЕТИЧЕСКОЙ МЕДИЦИНЕ
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- Authors
- Bai, G., Truong, T. M., Pathak, G. N., Benoit, L., & Rao, B.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- IEH Laboratories and Consulting Group , Lake Forest Park, Washington ,
- Weill Cornell Medicine (US)
- Corresponding author
- Bai, Ge
- Venue
- Skin Health and Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-02-13
- Volume
- 4
- Issue
- 6
- Pages
- e348-e348
- ISSN
- 2690-442X (ISSN-L)
- PMC
- PMC11608875
- OpenAlex
- W4391786146
- Cited by
- 32
- References
- 38
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 5
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Skin Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- This article received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- exosomes, extracellular vesicles, cosmetic dermatology, skin regeneration, wound healing, skin grafting, hair loss, biomarkers, drug carriers, exosome isolation
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