The biology , function , and biomedical applications of exosomes

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,774 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works

Reassessment of exosome composition

Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975 · see citing works

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0392-8 · Cited by 2,813 · see citing works

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

Current knowledge on exosome biogenesis and release

Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Regulation of immune responses by extracellular vesicles

Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

The biology and function of exosomes in cancer

Kalluri, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81135 · Cited by 1,849 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730 · see citing works

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666 · see citing works

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Wurdinger, T. D., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,648 · see citing works

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Zhang, H., Freitas, D. P., Kim, H. S., Fabijanic, K. I., Li, Z., Chen, H., Mark, M. T., Molina, H., Benito‐Martín, A., Bojmar, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0040-4 · Cited by 1,623 · see citing works

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Thakur, B. K., Zhang, H., Becker, A., Matei, I. R., Huang, Y., Costa‐Silva, B., Zheng, Y., Hoshino, A., Brazier, H., Xiang, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.44 · Cited by 1,592 · see citing works

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kügler, S., & Ikezu, T. (2015) · Nature Neuroscience · doi:10.1038/nn.4132 · Cited by 1,591 · see citing works

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Parolini, I., Federici, C., Raggi, C., Lugini, L., Palleschi, S., Milito, A. D., Coscia, C., Iessi, E., Logozzi, M., Molinari, A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041152 · Cited by 1,561 · see citing works

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,561 · see citing works

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Le‐Deygen, I. M., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky‐Papkov, M., Okolie, O., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,498 · see citing works

Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476 · see citing works

ExoCarta: A Web-Based Compendium of Exosomal Cargo

Keerthikumar, S., Chisanga, D., Ariyaratne, D., Saffar, H. A., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.019 · Cited by 1,447 · see citing works

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435 · see citing works

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Poggio, M., Hu, T., Pai, C.-C., Chu, B., Belair, C. D., Chang, A., Montabana, E., Lang, U. E., Fu, Q., Fong, L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.016 · Cited by 1,376 · see citing works

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · cited 1× · see citing works

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242 · see citing works

Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

Admyre, C., Johansson, S. M., Qazi, K. R., Filén, J., Lahesmaa, R., Norman, M., Neve, E. P. A., Scheynius, A., & Gabrielsson, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1969 · Cited by 1,222 · see citing works

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., Chow, A., O’Connor, S. T. F., Li, S., Chin, A. R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3094 · Cited by 1,118 · see citing works

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Qu, L., Ding, J., Chen, C. Y., Wu, Z., Liu, B., Gao, Y., Chen, W., Liu, F., Sun, W. C., Li, X., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.004 · Cited by 1,116 · see citing works

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H. A., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,101 · see citing works

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

Kordelas, L., Rebmann, V., Ludwig, A., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P., Beelen, D. W., & Giebel, B. (2014) · Leukemia · doi:10.1038/leu.2014.41 · Cited by 1,086 · see citing works

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works

Exosomes: Therapy delivery tools and biomarkers of diseases

Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,038 · see citing works

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Chalmin, F., Ladoire, S., Mignot, G., Vincent, J., Bruchard, M., Rémy-Martin, J.-P., Boireau, W., Rouleau, A., Simon, B., Lanneau, D., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40483 · Cited by 999 · see citing works

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Willms, E., Cabañas, C., Mäger, I., Wood, M. J. A., & Vader, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00738 · Cited by 982 · see citing works

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939 · see citing works

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 904 · see citing works

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J. P., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 850 · see citing works

Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis

Kahlert, C., & Kalluri, R. (2013) · Journal of molecular medicine · doi:10.1007/s00109-013-1020-6 · Cited by 842 · see citing works

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell‐free blood

Cheng, L., Sharples, R. A., Scicluna, B. J., & Hill, A. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23743 · Cited by 840 · see citing works

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R., de Wit, E., Berenguer, J., Ellenbroek, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 815 · see citing works

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M., & Baglio, S. R. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.013 · Cited by 815 · see citing works

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Besse, B., Charrier, M., Lapierre, V., Dansin, É., Lantz, O. J., Planchard, D., Chevalier, T. L., Livartoski, A., Barlési, F., Laplanche, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1071008 · Cited by 802 · see citing works

Generation and testing of clinical-grade exosomes for pancreatic cancer

Mendt, M. C., Kamerkar, S., Sugimoto, H., McAndrews, K. M., Wu, C.-C., Gagea, M., Yang, S., Blanko, E. V. R., Peng, Q., Ma, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99263 · Cited by 795 · see citing works

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

Yeung, C. L. A., Co, N.-N., Tsuruga, T., Yeung, T.-L., Kwan, S., Leung, C. S., Li, Y., Lu, E. S., Kwan, K., Wong, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11150 · Cited by 776 · see citing works

Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles

Andreola, G., Rivoltini, L., Castelli, C., Huber, V., Perego, P., Deho, P., Squarcina, P., Accornero, P., Lozupone, F., Lugini, L., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011624 · Cited by 773 · see citing works

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

Pathan, M., Fonseka, P., Chitti, S. V., Kang, T., Sanwlani, R., Deun, J. V., Hendrix, A., & Mathivanan, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1029 · Cited by 769 · see citing works

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

Boelens, M., Wu, T. J., Nabet, B., Xu, B.-H., Qiu, Y., Yoon, T., Azzam, D. J., Victor, C. T.-S., Wiemann, B., Ishwaran, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.051 · Cited by 768 · see citing works

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M. T., Obuse, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15287 · Cited by 761 · see citing works

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Katakowski, M., Buller, B., Zheng, X., Lü, Y., Rogers, T., Osobamiro, O. O., Shu, W., Jiang, F., & Chopp, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.019 · Cited by 748 · see citing works

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

Sansone, P., Savini, C., Kurelac, I., Chang, Q., Amato, L. B., Strillacci, A., Степанова, А., Iommarini, L., Mastroleo, C., Daly, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704862114 · Cited by 732 · see citing works

Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726 · see citing works

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

Feng, Z., Hensley, L., McKnight, K. L., Hu, F., Madden, V. J., Ping, L., Jeong, S., Walker, C. M., Lanford, R. E., & Lemon, S. M. (2013) · Nature · doi:10.1038/nature12029 · Cited by 712 · see citing works

Extracellular vesicles round off communication in the nervous system

Budnik, V., Ruiz-Cañada, C., & Wendler, F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.29 · Cited by 712 · see citing works

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

Liu, Y., Gu, Y. H., Han, Y., Zhang, Q., Jiang, Z., Zhang, X., Huang, B., Xu, X., Zheng, J., & Cao, X. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.021 · Cited by 642 · see citing works

The Trojan exosome hypothesis

Gould, S. J., Booth, A. M., & Hildreth, J. E. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831413100 · Cited by 638 · see citing works

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Yuan, D., Zhao, Y., Banks, W. A., Bullock, K. M., Haney, M., Batrakova, E., & Kabanov, A. V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.011 · Cited by 607 · see citing works

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

Yoshioka, Y., Kosaka, N., Konishi, Y., Ohta, H., Okamoto, H., Sonoda, H., Nonaka, R., Yamamoto, H., Ishii, H., Mori, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4591 · Cited by 601 · see citing works

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Zhu, X., Badawi, M. A., Pomeroy, S. M., Sutaria, D. S., Xie, Z., Baek, A., Jiang, J., Elgamal, O. A., Mo, X. M., Perle, K. L., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1324730 · Cited by 588 · see citing works

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

Pigati, L., Yaddanapudi, S. C., Iyengar, R., Kim, D.-J., Hearn, S., Danforth, D. N., Hastings, M. L., & Duelli, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013515 · Cited by 584 · see citing works

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

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Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

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Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

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HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

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Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

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Potential role of HER2‐overexpressing exosomes in countering trastuzumab‐based therapy

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Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

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Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

Ramakrishnaiah, V., Thumann, C., Fofana, I., Habersetzer, F., Pan, Q., de Ruiter, P. E., Willemsen, R., Demmers, J., Raj, V. S., Jenster, G. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221899110 · Cited by 503 · see citing works

Extracellular vesicles and viruses: Are they close relatives?

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Human placental trophoblasts confer viral resistance to recipient cells

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High prevalence of mutantKRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients

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Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

Feng, Y., Huang, W. C., Mashhood, W., Yu, X., & Ashraf, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088685 · Cited by 476 · see citing works

Phosphoproteins in extracellular vesicles as candidate markers for breast cancer

Chen, I.-H., Xue, L., Hsu, C., Paez, S. J., Pan, L., Aguilar, H. A., Wendt, M. K., Iliuk, A. B., Zhu, J., & Tao, W. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618088114 · Cited by 472 · see citing works

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

Mao, G., Zhang, Z., Hu, S., Zhang, Z., Chang, Z., Huang, Z., Liao, W., & Kang, Y. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1004-0 · Cited by 462 · see citing works

Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis

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Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Melo, S. A., Sugimoto, H., O'Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L., Melo, C., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 453 · see citing works

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Nabet, B. Y., Qiu, Y., Shabason, J. E., Wu, T. J., Yoon, T., Kim, B. C., Benci, J. L., DeMichele, A. M., Tchou, J. C., Marcotrigiano, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.031 · Cited by 453 · see citing works

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

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Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

Genschmer, K. R., Russell, D. W., Lal, C. V., Szul, T., Bratcher, P. E., Noerager, B. D., Roda, M. A., Xu, X., Rezonzew, G., Viera, L., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.002 · Cited by 444 · see citing works

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

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Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

Stuendl, A., Kunadt, M., Kruse, N., Bartels, C., Moebius, W., Danzer, K. M., Mollenhauer, B., & Schneider, A. (2016) · Brain · doi:10.1093/brain/awv346 · Cited by 428 · see citing works

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

Castaño, C., Kalko, S. G., Novials, A., & Párrizas, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808855115 · Cited by 422 · see citing works

Exosomes: Mechanisms of Uptake

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Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

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Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 416 · see citing works

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

Chen, W.-X., Liu, X.-M., Lv, M., Chen, L., Zhao, J.-H., Zhong, S., Ji, M., Hu, Q., Luo, Z., Wu, J.-Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095240 · Cited by 413 · see citing works

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

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Exosomal miRNAs as cancer biomarkers and therapeutic targets

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Mechanisms associated with biogenesis of exosomes in cancer

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A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer

Lai, X., Wang, M., McElyea, S. D., Sherman, S., House, M. G., & Korc, M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.019 · Cited by 386 · see citing works

Qualitative differences in T‐cell activation by dendritic cell‐derived extracellular vesicle subtypes

Tkach, M., Kowal, J., Zucchetti, A. E., Enserink, L. N. F. L., Jouve, M. J., Lankar, D., Saitakis, M., Jaular, L. M., & Théry, C. (2017) · The EMBO Journal · doi:10.15252/embj.201696003 · Cited by 381 · see citing works

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Torralba, D., Baixauli, F., Villarroya‐Beltri, C., Fernández‐Delgado, I., Latorre, A., Acín‐Pérez, R., Martin-Cofreces, N. B., Jaso-Tamame, A. L., Iborra, S., Jorge, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05077-9 · Cited by 376 · see citing works

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

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Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

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Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

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Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer

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KRAS-dependent sorting of miRNA to exosomes

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Exosome secretion is a key pathway for clearance of pathological TDP-43

Iguchi, Y., Eid, L., Parent, M., Soucy, G., Bareil, C., Riku, Y., Kawai, K., Takagi, S., Yoshida, M., Katsuno, M., et al. (2016) · Brain · doi:10.1093/brain/aww237 · Cited by 360 · see citing works

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

Ying, X., Wu, Q., Wu, X., Zhu, Q., Wang, X., Jiang, L., Chen, X., & Wang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.9246 · Cited by 349 · see citing works

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

Verweij, F. J., Revenu, C., Arras, G., Dingli, F., Loew, D., Pegtel, D. M., Follain, G., Allio, G., Goetz, J. G., Zimmermann, P., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.004 · Cited by 345 · see citing works

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

Binenbaum, Y., Fridman, E., Yaari, Z. A., Milman, N., Schroeder, A., David, G. B., Shlomi, T., & Gil, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0124 · Cited by 339 · see citing works

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

Yokoi, A., Yoshioka, Y., Yamamoto, Y., Ishikawa, M., Ikeda, S.-I., Kato, T., Kiyono, T., Takeshita, F., Kajiyama, H., Kikkawa, F., et al. (2017) · Nature Communications · doi:10.1038/ncomms14470 · Cited by 336 · see citing works

Mast Cell-Dependent B and T Lymphocyte Activation Is Mediated by the Secretion of Immunologically Active Exosomes

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Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

Vallabhaneni, K. C., Penfornis, P., Dhule, S. S., Guillonneau, F., Adams, K. V., Mo, Y. Y., Xu, R., Liu, Y., Watabe, K., Vemuri, M. C., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.3211 · Cited by 333 · see citing works

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

Hu, Y.-B., Yan, C., Mu, L., Huang, K., Li, X.-L., Tao, D., Wu, Y.-Q., & Qin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125625 · Cited by 328 · see citing works

Role of exosomes in sperm maturation during the transit along the male reproductive tract

Sullivan, R., Saez, F., Girouard, J., & Frenette, G. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.03.005 · Cited by 320 · see citing works

Protocells and RNA Self-Replication

Joyce, G. F., & Szostak, J. W. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034801 · Cited by 308 · see citing works

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

Cossetti, C., Iraci, N., Mercer, T. R., Leonardi, T., Alpi, E., Drago, D., Alfaro‐Cervelló, C., Saini, H. K., Davis, M. P. A., Schaeffer, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.020 · Cited by 301 · see citing works

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

Ciardiello, C., Cavallini, L., Spinelli, C., Yang, J., Reis-Sobreiro, M., de Candia, P., Minciacchi, V. R., & Vizio, D. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020175 · Cited by 301 · see citing works

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Kitai, Y., Kawasaki, T., Sueyoshi, T., Kobiyama, K., Ishii, K., Zou, J., Akira, S., Matsuda, T., & Kawai, T. (2017) · Journal of Immunology · doi:10.4049/jimmunol.1601694 · Cited by 296 · see citing works

Neoplastic Reprogramming of Patient-Derived Adipose Stem Cells by Prostate Cancer Cell-Associated Exosomes

Elmageed, Z. Y. A., Yang, Y., Thomas, R., Ranjan, M., Mondal, D., Moroz, K., Fang, Z., Rezk, B. M., Moparty, K., Sikka, S. C., et al. (2013) · Stem Cells · doi:10.1002/stem.1619 · Cited by 295 · see citing works

Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting

van Balkom, B. W. M., Eisele, A. S., Pegtel, D. M., Bervoets, S., & Verhaar, M. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26760 · Cited by 294 · see citing works

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

Gabrusiewicz, K., Li, X., Wei, J., Hashimoto, Y., Marisetty, A., Ott, M., Wang, F., Hawke, D., Yu, J., Healy, L. M., et al. (2017) · Oncoimmunology · doi:10.1080/2162402x.2017.1412909 · Cited by 291 · see citing works

Exosomes in the Pathology of Neurodegenerative Diseases

Howitt, J. A., & Hill, A. F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.757955 · Cited by 287 · see citing works

Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p

Ding, G., Zhou, L., Qian, Y., Fu, M., Chen, J., Chen, J., Xiang, J., Wu, Z., Jiang, G., & Cao, L. (2015) · Oncotarget · doi:10.18632/oncotarget.4924 · Cited by 285 · see citing works

Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells

Vincent-Schneider, H. (2002) · International Immunology · doi:10.1093/intimm/dxf048 · Cited by 285 · see citing works

Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Masyuk, A. I., Masyuk, T. V., & LaRusso, N. F. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.028 · Cited by 283 · see citing works

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

Lewis, J. M., Vyas, A. D., Qiu, Y., Messer, K. S., White, R., & Heller, M. J. (2018) · ACS Nano · doi:10.1021/acsnano.7b08199 · Cited by 283 · see citing works

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Yang, K. S., Im, H., Hong, S., Pergolini, I., del Castillo, A. F., Wang, R., Clardy, S. M., Huang, C.-H., Pille, C., Ferrone, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3226 · Cited by 275 · see citing works

microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer

Bhagirath, D., Yang, T. L., Bucay, N., Sekhon, K., Majid, S., Shahryari, V., Dahiya, R., Tanaka, Y., & Saini, S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2069 · Cited by 275 · see citing works

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

Basso, M., Pozzi, S., Tortarolo, M., Fiordaliso, F., Bisighini, C., Pasetto, L., Spaltro, G., Lidonnici, D., Gensano, F., Battaglia, E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425066 · Cited by 274 · see citing works

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Plebanek, M. P., Angeloni, N. L., Vinokour, E., Li, J., Henkin, A., Martinez-Marin, D., Filleur, S., Bhowmick, R., Henkin, J., Miller, S. D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01433-3 · Cited by 273 · see citing works

Exosomal MicroRNA MiR-1246 Promotes Cell Proliferation, Invasion and Drug Resistance by Targeting CCNG2 in Breast Cancer

Li, X. J., Ren, Z. J., Tang, J. H., & Yu, Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485780 · Cited by 268 · see citing works

New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes

Fernando, M. R., Jiang, C. Y., Krzyzanowski, G. D., & Ryan, W. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183915 · Cited by 266 · see citing works

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

Montecalvo, A., Shufesky, W. J., Stolz, D. B., Sullivan, M., Wang, Z., Divito, S. J., Papworth, G. D., Watkins, S. C., Robbins, P. D., Larregina, A. T., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3081 · Cited by 265 · see citing works

A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐β peptide

Yuyama, K., Sun, H., Usuki, S., Sakaï, S., Hanamatsu, H., Mioka, T., Kimura, N., Okada, M., Tahara, H., Furukawa, J., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.11.027 · Cited by 263 · see citing works

Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients

Castillo, J., Bernard, V., Lucas, F. A. S., Allenson, K., Capello, M., Kim, D. U., Gascoyne, P. R. C., Mulu, F. C., Stephens, B. M., Huang, J. H., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx542 · Cited by 262 · see citing works

Exosomes Derived from M. Bovis BCG Infected Macrophages Activate Antigen-Specific CD4+ and CD8+ T Cells In Vitro and In Vivo

Giri, P. K., & Schorey, J. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002461 · Cited by 255 · see citing works

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

Cai, J., Han, Y., Ren, H., Chen, C., He, D., Zhou, L., Eisner, G. M., Asico, L. D., José, P. A., & Zeng, C. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt011 · Cited by 253 · see citing works

Exosomal miRNAs as novel cancer biomarkers: Challenges and opportunities

Salehi, M., & Sharifi, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26481 · Cited by 252 · see citing works

The Origin and Functions of Exosomes in Cancer

Rajagopal, C., & Harikumar, K. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00066 · Cited by 252 · see citing works

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Yang, S., Che, S. P. Y., Kurywchak, P., Tavormina, J. L., Gansmo, L. B., Correa de Sampaio, P., Tachezy, M., Bockhorn, M., Gebauer, F., Haltom, A. R., et al. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1281499 · Cited by 248 · see citing works

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Zhang, G., Liu, Z., Ding, H., Zhou, Y., Doan, H. A., Sin, K. W. T., Zhu, Z. J., Flores, R., Wen, Y., Gong, X., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00726-x · Cited by 248 · see citing works

Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue

Sagar, G., Sah, R. P., Javeed, N., Dutta, S. K., Smyrk, T. C., Lau, J. S., Giorgadze, N., Tchkonia, T., Kirkland, J. L., Chari, S. T., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308350 · Cited by 247 · see citing works

Exosomes as new players in metabolic organ cross‐talk

Guay, C., & Regazzi, R. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13027 · Cited by 241 · see citing works

Tumor exosomes block dendritic cells maturation to decrease the T cell immune response

Ning, Y., Shen, K., Wu, Q., Sun, X. Y., Bai, Y., Xie, Y., Pan, J., & Qi, C. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.05.002 · Cited by 236 · see citing works

Pharmacokinetics of Exosomes—An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

Morishita, M., Takahashi, Y., Nishikawa, M., & Takakura, Y. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.02.030 · Cited by 233 · see citing works

Extracellular vesicles in parasitic diseases

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