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Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Abstract
A series of gold nanoparticles were examined for uptake and acute toxicity in human leukemia cells. The nanoparticles (average diameter=18 nm), which possessed various surface modifiers, were not toxic to cells during continuous exposure for three days. Citrate-capped nanoparticles were further examined for their cellular uptake by absorbance and transmission electron microscopy (see image). Results indicate that although some precursors of nanoparticles may be toxic, the nanoparticles themselves are not necessarily detrimental to cellular function.
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Citations
Cited by
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, B. D., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,879
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
Singh, P., Pandit, S., Mokkapati, V. R. S. S., Garg, A., Ravikumar, V., & Mijakovic, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071979 · Cited by 1,038
Metadata
- Authors
- Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2005-01-28
- Volume
- 1
- Issue
- 3
- Pages
- 325-327
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2137335948
- Cited by
- 2,406
- References
- 0
- FWCI
- 33.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005). Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity. Small. https://doi.org/10.1002/smll.200400093
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
