Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
Open accessAbstract
The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications. These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature. Moreover, the non-toxic and non-immunogenic nature of gold nanoparticles and the high permeability and retention effect provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Various innovative approaches with gold nanoparticles are under development. In this review, we provide an overview of recent progress made in the application of gold nanoparticles in the treatment of cancer by tumor detection, drug delivery, imaging, photothermal and photodynamic therapy and their current limitations in terms of bioavailability and the fate of the nanoparticles.
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The non-toxic, non-immunologic, highly permeable, and retention effects of gold nanoparticles make them more likely to infiltrate into the tumor site and to produce better therapeutic effects.
“Furthermore, the non-toxic, non-immunologic, highly permeable, and retention effects of gold nanoparticles make them more likely to infiltrate into the tumor site and to produce better therapeutic effects.80”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [80]
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Self-citationTarantino, S., Bianco, A., Cascione, M., Carlà, A., Fiamà, L., Di Corato, R., Giotta, L., Pellegrino, P., Caricato, A. P., Rinaldi, R., et al. (2025) · Discover Nano · doi:10.1186/s11671-025-04186-x · Cited by 10 · see citing works
- Authors
- Singh, P., Pandit, S., Mokkapati, V. R. S. S., Garg, A., Ravikumar, V., & Mijakovic, I.
- Affiliations
- Novo Nordisk Foundation (DK)
- Chalmers University of Technology (SE)
- The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-07-06
- Volume
- 19
- Issue
- 7
- Pages
- 1979
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6073740
- OpenAlex
- W2850142515
- Cited by
- 1,038
- References
- 91
- Citations by year
- 2026: 55 · 2025: 107 · 2024: 131 · 2023: 149 · 2022: 173 · 2021: 207 · 2020: 140 · 2019: 64 · 2018: 12
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, cc-by)
- Funders
- VINNOVA
- Novo Nordisk
- Novo Nordisk Fonden (NNF10CC1016517)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- gold nanoparticles, cancer diagnosis, cancer therapeutics, tumor targeting, drug delivery, surface plasmon resonance, photothermal therapy, photodynamic therapy, tumor imaging, PEGylation, nanoparticle bioavailability, nanoparticle fate
- MeSH terms
- Drug Carriers, Gold, Humans, Materials Testing, Neoplasms, Phototherapy, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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