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Assessing Methods for Blood Cell Cytotoxic Responses to Inorganic Nanoparticles and Nanoparticle Aggregates
Abstract
Inorganic nanoparticles (NPs) show great potential for medicinal therapy. However, biocompatibility studies are essential to determine if they are safe. Here, five different NPs are compared for their cytotoxicity, internalization, aggregation in medium, and reactive oxygen species (ROS) production, using tumoral and normal human blood cells. Differences depending on the cell type are analyzed, and no direct correlation between ROS production and cell toxicity is found. Results are discussed with the aim of standardizing the procedures for the evaluation of the toxicity.
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Cites
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Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
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Nanoparticle colloidal stability in cell culture media and impact on cellular interactions
Moore, T. L., Rodriguez-Lorenzo, L., Hirsch, V., Balog, S., Urban, D., Jud, C., Rothen-Rutishauser, B., Lattuada, M., & Petri-Fink, A. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00487f · Cited by 1,082
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Soenen, S. J., Rivera-Gil, P., Montenegro, J.-M., Parak, W. J., De Smedt, S. C., & Braeckmans, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.001 · Cited by 699
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Metadata
- Authors
- Díaz, B., Sánchez‐Espinel, C., Arruebo, M., Faro, J., de Miguel, E., Magadán, S., Yagüe, C., Fernández‐Pacheco, R., Ibarra, M. R., Santamaría, J., & González‐Fernández, Á.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2008-11
- Volume
- 4
- Issue
- 11
- Pages
- 2025-2034
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2069022842
- Cited by
- 182
- References
- 1
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Díaz, B., Sánchez‐Espinel, C., Arruebo, M., Faro, J., de Miguel, E., Magadán, S., Yagüe, C., Fernández‐Pacheco, R., Ibarra, M. R., Santamaría, J., & González‐Fernández, Á. (2008). Assessing Methods for Blood Cell Cytotoxic Responses to Inorganic Nanoparticles and Nanoparticle Aggregates. Small. https://doi.org/10.1002/smll.200800199
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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