The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anti‐inflammatory Properties of Cerium Oxide Nanoparticles
Abstract
The valence and oxygen defect properties of cerium oxide nanoparticles (nanoceria) suggest that they may act as auto‐regenerative free radical scavengers. Overproduction of the free radical nitric oxide (NO) by the enzyme inducible nitric oxide synthase (iNOS) has been implicated as a critical mediator of inflammation. NO is correlated with disease activity and contributes to tissue destruction. The ability of nanoceria to scavenge free radicals, or reactive oxygen species (ROS), and inhibit inflammatory mediator production in J774A.1 murine macrophages is investigated. Cells internalize nanoceria, the treatment is nontoxic, and oxidative stress and pro‐inflammatory iNOS protein expression are abated with stimulation. In vivo studies show nanoceria deposition in mouse tissues with no pathogenicity. Taken together, it is suggested that cerium oxide nanoparticles are well tolerated in mice and are incorporated into cellular tissues. Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation.
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Cites
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
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Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Fundamentals and Catalytic Applications of CeO 2 -Based Materials
Montini, T., Melchionna, M., Monai, M., & Fornasiero, P. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00603 · Cited by 2,766
Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Self-citationCerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications
Dhall, A., & Self, W. (2018) · Antioxidants · doi:10.3390/antiox7080097 · Cited by 482
Lee, S. S., Song, W., Cho, M., Puppala, H. L., Nguyen, P., Zhu, H., Segatori, L., & Colvin, V. L. (2013) · ACS Nano · doi:10.1021/nn4026806 · Cited by 414
Metadata
- Authors
- Hirst, S. M., Karakoti, A. S., Tyler, R. D., Sriranganathan, N., Seal, S., & Reilly, C. M.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2009-12-14
- Volume
- 5
- Issue
- 24
- Pages
- 2848-2856
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2022556212
- Cited by
- 727
- References
- 1
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hirst, S. M., Karakoti, A. S., Tyler, R. D., Sriranganathan, N., Seal, S., & Reilly, C. M. (2009). Anti‐inflammatory Properties of Cerium Oxide Nanoparticles. Small. https://doi.org/10.1002/smll.200901048
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