Uniform Beads with Controllable Pore Sizes for Biomedical Applications
Open accessAbstract
Uniform beads of poly(D,L-lactide-co- glycolide) with small or large pores are fabricated by selectively introducing phase-separated layers of an unstable emulsion into a fluidic device using a syringe with a tip offset from the barrel. When fibroblasts are cultured in the beads, a higher density of viable cells occurs in the beads with larger pores. These beads could be useful for tissue engineering and cell-delivery applications.
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Some important characteristics of cancer cells cannot be appropriately modeled in 2D cultures.
“For instance, some important characteristics of cancer cells cannot be appropriately modeled in 2D cultures (22).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [22]
The Experimental Section describes culturing NIH-3T3 fibroblasts in porous beads, and the paper’s discussion of three-dimensional matrices concerns cell viability. Searches for cancer cells and comparisons with 2D cultures found no passage addressing whether 2D cultures inadequately model cancer-cell characteristics; page numbers were not available in our copy. (LLM, conf=0.74)
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- [17]Senuma Y Franceschin S Hilborn JG Tissières P Bisson I Frey P Biomaterials 2000 21 1135 10817266
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Modeling physiological events in 2D vs. 3D cell culture
Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849 · see citing works
- Authors
- Choi, S., Yeh, Y., Zhang, Y., Sung, H., & Xia, Y.
- Affiliations
- Washington University in St. Louis (US)
- National Tsing Hua University (TW)
- Venue
- Small
- Publisher
- Wiley
- Published
- 2010-07-09
- Volume
- 6
- Issue
- 14
- Pages
- 1492-1498
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- PMC
- PMC3011368
- OpenAlex
- W2136609878
- Cited by
- 81
- References
- 30
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP1OD000798)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- poly(lactic-co-glycolic acid), porous beads, pore size control, phase separation, fluidic devices, fibroblast culture, cell viability, tissue engineering, cell delivery
- MeSH terms
- Animals, Emulsions, Microscopy, Electron, Scanning, Microscopy, Fluorescence, 3T3 Cells, Bioreactors, Hydrogels, Mice
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