The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells
Open accessAbstract
The ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) into Ewing sarcoma cells is investigated with a view to the possibility of in‐vivo anticancer nucleic‐acid drug delivery. siRNA is adsorbed onto NDs that are coated with cationic polymer. Cell uptake of NDs is demonstrated by taking advantage of the NDs’ intrinsic fluorescence from embedded color‐center defects. Cell toxicity of these coated NDs is shown to be low. Consistent with the internalization efficacy, a specific inhibition of EWS/Fli‐1 gene expression is shown at the mRNA and protein level by the ND‐vectorized siRNA in a serum‐containing medium.
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Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Cited by
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Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Nanoparticles in Drug Delivery: From History to Therapeutic Applications
Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., et al. (2022) · Nanomaterials · doi:10.3390/nano12244494 · Cited by 468
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Metadata
- Authors
- Alhaddad, A., Adam, M., Botsoa, J., Dantelle, G., Perruchas, S., Gacoin, T., Mansuy, C., Lavielle, S., Malvy, C., Treussart, F., & Bertrand, J.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2011-09-12
- Volume
- 7
- Issue
- 21
- Pages
- 3087-3095
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2594430330
- Cited by
- 231
- References
- 1
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Alhaddad, A., Adam, M., Botsoa, J., Dantelle, G., Perruchas, S., Gacoin, T., Mansuy, C., Lavielle, S., Malvy, C., Treussart, F., & Bertrand, J. (2011). Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells. Small. https://doi.org/10.1002/smll.201101193
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