Cited by 367Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDrug Transport and Resistance Mechanisms

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Open access
Gurunathan, Sangiliyandi, Kang, Min-Hee, Qasim, Muhammad, Kim, Jin-Hoi·2018·International Journal of Molecular Sciences

Abstract

Cancer represents a group of heterogeneous diseases characterized by uncontrolled growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a significant role in the development of nanodrugs, nanodevices, drug delivery systems and nanocarriers. Some of the major issues in the treatment of cancer are multidrug resistance (MDR), narrow therapeutic window and undesired side effects of available anticancer drugs and the limitations of anticancer drugs. Several nanosystems being utilized for detection, diagnosis and treatment such as theranostic carriers, liposomes, carbon nanotubes, quantum dots, polymeric micelles, dendrimers and metallic nanoparticles. However, nonbiodegradable nanoparticles causes high tissue accumulation and leads to toxicity. MDR is considered a major impediment to cancer treatment due to metastatic tumors that develop resistance to chemotherapy. MDR contributes to the failure of chemotherapies in various cancers, including breast, ovarian, lung, gastrointestinal and hematological malignancies. Moreover, the therapeutic efficiency of anticancer drugs or nanoparticles (NPs) used alone is less than that of the combination of NPs and anticancer drugs. Combination therapy has long been adopted as the standard first-line treatment of several malignancies to improve the clinical outcome. Combination therapy with anticancer drugs has been shown to generally induce synergistic drug actions and deter the onset of drug resistance. Therefore, this review is designed to report and analyze the recent progress made to address combination therapy using NPs and anticancer drugs. We first provide a comprehensive overview of the angiogenesis and of the different types of NPs currently used in treatments of cancer; those emphasized in this review are liposomes, polymeric NPs, polymeric micelles (PMs), dendrimers, carbon NPs, nanodiamond (ND), fullerenes, carbon nanotubes (CNTs), graphene oxide (GO), GO nanocomposites and metallic NPs used for combination therapy with various anticancer agents. Nanotechnology has provided the convenient tools for combination therapy. However, for clinical translation, we need continued improvements in the field of nanotechnology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms19103264

Cites

219 of 219 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

1 of the 220 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [58]Mewani R. Li B. Danner M. Carr T. Lee S. Kasid U. Jung M. Dritschilo A. Gokhale P.C. Analysis of gene expression in breast cancer cells treated with antisense raf oligonucleotide using microarray Proc. Am. Assoc. Cancer Res. 2004 64 1209 1210

Cited by

Sorted by citations

Authors
Gurunathan, S., Kang, M.-H., Qasim, M., & Kim, J.-H.
Affiliations
Konkuk University (KR)
Corresponding author
  • Gurunathan, Sangiliyandi
  • Kim, Jin-Hoi
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-10-20
Volume
19
Issue
10
Pages
3264
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2896053285
Cited by
367
References
220
Citations by year
2026: 26 · 2025: 55 · 2024: 55 · 2023: 51 · 2022: 57 · 2021: 52 · 2020: 47 · 2019: 24
FWCI
2.03
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
cancer nanomedicine, multidrug resistance, anticancer drug delivery, liposomes, polymeric micelles, dendrimers, carbon nanotubes, graphene oxide, nanodiamonds, C60, metal nanoparticles, angiogenesis, theranostic nanocarriers, drug synergy
MeSH terms
Animals, Antineoplastic Agents, Drug Therapy, Combination, Humans, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review