The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
siRNA Delivery Strategies: A Comprehensive Review of Recent Developments
Open accessAbstract
siRNA is a promising therapeutic solution to address gene overexpression or mutations as a post-transcriptional gene regulation process for several pathological conditions such as viral infections, cancer, genetic disorders, and autoimmune disorders like arthritis. This therapeutic method is currently being actively pursued in cancer therapy because siRNA has been found to suppress the oncogenes and address mutations in tumor suppressor genes and elucidate the key molecules in cellular pathways in cancer. It is also effective in personalized gene therapy for several diseases due to its specificity, adaptability, and broad targeting capability. However, naked siRNA is unstable in the bloodstream and cannot efficiently cross cell membranes besides being immunogenic. Therefore, careful design of the delivery systems is essential to fully utilize the potential of this therapeutic solution. This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems.
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Cites
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mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
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Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
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Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
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Metadata
- Authors
- Tatiparti, K., Sau, S., Kashaw, S., & Iyer, A.
- Venue
- Nanomaterials
- Publisher
- MDPI AG
- Published
- 2017-04-05
- Volume
- 7
- Issue
- 4
- Pages
- 77
- ISSN
- 2079-4991 (ISSN-L)
- OpenAlex
- W2605100193
- Cited by
- 429
- References
- 79
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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