Optical Sensor for Real-Time pH Monitoring in Human Tissue
Abstract
This article reports on a fiber-based ratiometric optical pH sensor for use in real-time and continuous in vivo pH monitoring in human tissue. Stable hybrid sol-gel-based pH sensing material is deposited on a highly flexible plastic optical fiber tip and integrated with excitation and detection electronics. The sensor is extensively tested in a laboratory environment before it is applied in vivo in a human model. The pH sensor performance in the laboratory environment outperforms the state-of-the-art reported in the current literature. It exhibits the highest sensitivity in the physiological pH range, resolution of 0.0013 pH units, excellent sensor to sensor reproducibility, long-term stability, short response time of <2 min, and drift of 0.003 pH units per 22 h. The sensor also exhibits promising performance in in vitro whole blood samples. In addition, human evaluations conducted under this project demonstrate successful short-term deployment of this sensor in vivo.
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Fiber optic ratiometric sensors with a hybrid sol-gel pH sensing material on a flexible POF tip can measure in vivo pH in the physiological range with a resolution of 0.0013 pH units.
“The use of fiber optic sensors for in vivo pH measurement is possible using ratiometric sensors based on a hybrid sol-gel pH sensing material deposited on a highly flexible POF tip capable of operating in the physiological pH range with a resolution of 0.0013 pH units.”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [225]
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The Current State of Optical Sensors in Medical Wearables
Vavrinsky, E., Esfahani, N. E., Hausner, M., Kuzma, A., Rezo, V., Donoval, M., & Kosnacova, H. (2022) · Biosensors · doi:10.3390/bios12040217 · Cited by 103 · see citing works
- Authors
- Wencel, D., Kaworek, A., Abel, T., Efremov, V., Bradford, A., Carthy, D., Coady, G., McMorrow, R. C. N., & McDonagh, C.
- Affiliations
- Dublin City University (IE)
- BlueBridge Technologies 3015 Lake Drive, Citywest Campus, Citywest Dublin 24 Ireland
- F. Hoffmann-La Roche AG (CH)
- Royal College of Surgeons in Ireland (IE)
- National Maternity Hospital (IE)
- Corresponding author
- Wencel, Dorota
- Venue
- Small
- Publisher
- Wiley
- Published
- 2018-11-14
- Volume
- 14
- Issue
- 51
- Pages
- e1803627-e1803627
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2901730896
- Cited by
- 77
- References
- 33
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 8 · 2019: 5
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Enterprise Ireland (IP 2012 0181, IP 2014 0300A)
- Science Foundation Ireland (14/IFB/2704)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Fiber Optic Sensors
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- optical pH sensor, ratiometric sensing, fiber optic sensors, human tissue, sensor stability, real-time monitoring
- MeSH terms
- Fiber Optic Technology, Humans, Hydrogen-Ion Concentration, Optical Fibers
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