The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells
Open accessAbstract
The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration. How cells sense and respond to the topographical cues, e.g., interfacial roughness, is yet to be fully understood and even debatable. Here, the mechanotransduction and fate determination of human mesenchymal stem cells (MSCs) on surface roughness gradients are systematically studied. The broad range of topographical scales and high‐throughput imaging is achieved based on a catecholic polyglycerol coating fabricated by a one‐step‐tilted dip‐coating approach. It is revealed that the adhesion of MSCs is biphasically regulated by interfacial roughness. The cell mechanotransduction is investigated from focal adhesion to transcriptional activity, which explains that cellular response to interfacial roughness undergoes a direct force‐dependent mechanism. Moreover, the optimized roughness for promoting cell fate specification is explored.
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Cites
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Cited by
ZnO/Nanocarbons-Modified fibrous scaffolds for stem cell-based osteogenic differentiation
Xia, Y., Fan, X., Yang, H., Li, L., He, C., Cheng, C., & Haag, R. (2020) · Small · doi:10.1002/smll.202003010 · Cited by 79
Self-citationBiomaterial-based physical regulation of macrophage behaviour
Zhou, H., Xue, Y., Dong, L., & Wang, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00107h · Cited by 47
Metadata
- Authors
- Hou, Y., Xie, W., Yu, L., Camacho, L. C., Nie, C., Zhang, M., Haag, R., & Wei, Q.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2020-02-17
- Volume
- 16
- Issue
- 10
- Pages
- e1905422-e1905422
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3006172684
- Cited by
- 247
- References
- 3
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hou, Y., Xie, W., Yu, L., Camacho, L. C., Nie, C., Zhang, M., Haag, R., & Wei, Q. (2020). Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells. Small. https://doi.org/10.1002/smll.201905422
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