ZnO/Nanocarbons-Modified fibrous scaffolds for stem cell-based osteogenic differentiation
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Abstract Currently, mesenchymal stem cells (MSCs)‐based therapies for bone regeneration and treatments have gained significant attention in clinical research. Though many chemical and physical cues which influence the osteogenic differentiation of MSCs have been explored, scaffolds combining the benefits of Zn 2+ ions and unique nanostructures may become an ideal interface to enhance osteogenic and anti‐infective capabilities simultaneously. In this work, motivated by the enormous advantages of Zn‐based metal–organic framework‐derived nanocarbons, C‐ZnO nanocarbons‐modified fibrous scaffolds for stem cell‐based osteogenic differentiation are constructed. The modified scaffolds show enhanced expression of alkaline phosphatase, bone sialoprotein, vinculin, and a larger cell spreading area. Meanwhile, the caging of ZnO nanoparticles can allow the slow release of Zn 2+ ions, which not only activate various signaling pathways to guide osteogenic differentiation but also prevent the potential bacterial infection of implantable scaffolds. Overall, this study may provide new insight for designing stem cell‐based nanostructured fibrous scaffolds with simultaneously enhanced osteogenic and anti‐infective capabilities.
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Other studies demonstrated that porous scaffolds allowed hBMSCs to proliferate more easily and adhere to scaffold surfaces.
“other studies also demonstrated that porous scaffolds allowed hBMSCs proliferate more easily and adhere to scaffold surfaces [54,55].”
From Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. (2022) · cites this paper as [54]
The scaffold-results passage (section 2.1; page unavailable) reports that hMSCs adhered to the scaffolds, and the cell-adhesion analysis reports improved adhesion on carbon-nanomaterial-modified fibers. It does not identify the cells as bone-marrow-derived or show that porosity made proliferation easier: proliferation was largely unchanged at lower nanoparticle concentrations and decreased at the highest concentration. (LLM, conf=0.86)
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- Authors
- Xia, Y., Fan, X., Yang, H., Li, L., He, C., Cheng, C., & Haag, R.
- Affiliations
- Sichuan University (CN)
- Technische Universität Berlin (DE)
- Freie Universität Berlin (DE)
- Corresponding author
- Cheng, Chong
- Haag, Rainer
- Venue
- Small
- Publisher
- Wiley
- Published
- 2020-08-19
- Volume
- 16
- Issue
- 38
- Pages
- e2003010-e2003010
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3081445359
- Cited by
- 79
- References
- 60
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 22 · 2020: 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Small (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- National Basic Research Program of China (2019YFA0110600, 2019YFA0110601)
- Deutsche Forschungsgemeinschaft ((SFB) 765)
- China Scholarship Council
- State Key Laboratory of Polymer Materials Engineering (sklpme2019‐2‐03)
- Fundamental Research Funds for the Central Universities
- Donghua University (YJ202005)
- Sichuan University (2020scunCoV‐YJ‐20005)
- Ministry of Education (KLET‐201907)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- fibrous scaffolds, mesenchymal stem cells, osteogenic differentiation, zinc ion release, bone regeneration, anti-infection, bacterial infection prevention, alkaline phosphatase, bone sialoprotein
- MeSH terms
- Alkaline Phosphatase, Carbon, Cell Differentiation, Cells, Cultured, Humans, Materials Testing, Microscopy, Electron, Scanning, Osteogenesis, Zinc Oxide, Signal Transduction, Vinculin, Tissue Engineering, Tissue Scaffolds, Nanofibers, Integrin-Binding Sialoprotein, Mesenchymal Stem Cells
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