The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy
Abstract
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II PDT relying on 1 O 2 presents poor therapeutic efficacy for hypoxic tumors due to the oxygen‐dependent manner. Alternatively, emerging researches have demonstrated that type I PDT exhibits superiority over type II PDT in tumor treatment owing to its diminished oxygen‐dependence. In this review, state‐of‐the‐art studies concerning recent progress in type I photosensitizers are scrutinized, emphasizing the strategies to construct highly effective type I photosensitizers. As the foundation, basic principles of type I PDT are presented, and up‐to‐date type I photosensitizers are summarized and classified based on their attributes. Then, a literature review of representative type I photosensitizers (including nanomaterials and small molecules) is presented with impetus to delineate their novel designs, action mechanisms, as well as anticancer PDT applications. Finally, the remaining challenges and development directions of type I photosensitizers are outlined, highlighting key scientific issues toward clinical translations.
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Cited by
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Phototherapy in cancer treatment: strategies and challenges
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Wen, K., Tan, H., Peng, Q., Chen, H., Ma, H., Wang, L., Peng, A., Shi, Q., Cai, X., & Huang, H. (2022) · Advanced Materials · doi:10.1002/adma.202108146 · Cited by 298
Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death
Maharjan, P. S., & Bhattarai, H. K. (2022) · Journal of Oncology · doi:10.1155/2022/7211485 · Cited by 222
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Metadata
- Authors
- Chen, D., Xu, Q., Wang, W., Shao, J., Huang, W., & Dong, X.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2021-05-26
- Volume
- 17
- Issue
- 31
- Pages
- e2006742-e2006742
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3165504457
- Cited by
- 482
- References
- 112
- FWCI
- 42.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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