The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor
Open accessAbstract
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug‐resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, a novel in situ injectable HA@MnO 2/FGF‐2/Exos hydrogel is introduced for improving diabetic wound healing. Through a simple local injection, this hydrogel is able to form a protective barrier covering the wound, providing rapid hemostasis and long‐term antibacterial protection. The MnO 2/ε‐PL nanosheet is able to catalyze the excess H 2 O 2 produced in the wound, converting it to O 2, thus not only eliminating the harmful effects of H 2 O 2 but also providing O 2 for wound healing. Moreover, the release of M2‐derived Exosomes (M2 Exos) and FGF‐2 growth factor stimulates angiogenesis and epithelization, respectively. These in vivo and in vitro results demonstrate accelerated healing of diabetic wounds with the use of the HA@MnO 2/FGF‐2/Exos hydrogel, presenting a viable strategy for chronic diabetic wound repair.
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1 retracted
Xiong, Y., Chen, L., Yan, C., Zhou, W., Yu, T., Sun, Y., Cao, F., Xue, H., Hu, Y., Chen, D., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00622-5 · Cited by 163
Self-citationRetractedFunctional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing
Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine · doi:10.1038/nm.3887 · Cited by 1,264
Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2019) · Theranostics · doi:10.7150/thno.29766 · Cited by 908
Self-citationJang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894
ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds
Zhao, H., Huang, J., Li, Y., Lv, X., Zhou, H., Wang, H., Xu, Y., Wang, C., Wang, J., & Liu, Z. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120286 · Cited by 841
Strategy for Treatment of Infected Diabetic Foot Ulcers
Chang, M., & Nguyen, T. T. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00864 · Cited by 712
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Griffin, M., Borrelli, M. R., Moore, A. L., Chen, K., Duoto, B., Chinta, M., Foster, D. S., et al. (2021) · Science · doi:10.1126/science.aba2374 · Cited by 617
Cited by
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Huang, F., Lu, X., Yang, Y., Yang, Y., Li, Y., Kuai, L., Li, B., Dong, H., & Shi, J. (2023) · Advanced Science · doi:10.1002/advs.202203308 · Cited by 365
Dong, Q., Liang, X., Chen, F., Ke, M., Yang, X., Ai, J., Cheng, Q., Zhou, Y., & Chen, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.051 · Cited by 21
Metadata
- Authors
- Xiong, Y., Chen, L., Liu, P., Yu, T., Lin, C., Yan, C., Hu, Y., Zhou, W., Sun, Y., Panayi, A. C., Cao, F., Xue, H., Hu, L., Lin, Z., Xie, X., Xiao, X., Feng, Q., Mi, B., & Liu, G.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2021-11-17
- Volume
- 18
- Issue
- 1
- Pages
- e2104229-e2104229
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3213729392
- Cited by
- 331
- References
- 49
- FWCI
- 22.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xiong, Y., Chen, L., Liu, P., Yu, T., Lin, C., Yan, C., Hu, Y., Zhou, W., Sun, Y., Panayi, A. C., Cao, F., Xue, H., Hu, L., Lin, Z., Xie, X., Xiao, X., Feng, Q., Mi, B., & Liu, G. (2022). All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor. Small. https://doi.org/10.1002/smll.202104229
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
