The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Open accessAbstract
Regeneration without scarring: Wounds in adult mammals typically heal by forming fibrotic scars. Mascharak et al. found that a specific population of skin fibroblasts ( Engrailed-1 lineage–negative fibroblasts) activate expression of Engrailed-1 and turn on profibrotic cellular programs in response to local tissue mechanics in wounds (see the Perspective by Konieczny and Naik). When mechanical signaling was inhibited in these cells (using either genetic deletion or small-molecule inhibition), skin wounds in mice no longer formed scars but instead healed by regeneration, restoring skin with normal hair follicles and glands, extracellular matrix, and mechanical strength. Science , this issue p. eaba2374 ; see also p. 346
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Challenges and opportunities for the next generation of cardiovascular tissue engineering
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ECM formation and degradation during fibrosis, repair, and regeneration
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Metadata
- Authors
- Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Griffin, M., Borrelli, M. R., Moore, A. L., Chen, K., Duoto, B., Chinta, M., Foster, D. S., Shen, A. H., Januszyk, M., Kwon, S. H., Wernig, G., Wan, D. C., Lorenz, H. P., Gurtner, G. C., & Longaker, M. T.
- Venue
- Science
- Published
- 2021-04-23
- Volume
- 372
- Issue
- 6540
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3155386417
- Cited by
- 617
- References
- 10
- FWCI
- 38.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Griffin, M., Borrelli, M. R., Moore, A. L., Chen, K., Duoto, B., Chinta, M., Foster, D. S., Shen, A. H., Januszyk, M., Kwon, S. H., Wernig, G., Wan, D. C., Lorenz, H. P., Gurtner, G. C., & Longaker, M. T. (2021). Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. Science. https://doi.org/10.1126/science.aba2374
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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