The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds
Abstract
Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or bacterial infection could further impede wound healing. Here, a type of ROS-scavenging hydrogel is developed by using polyvinyl alcohol (PVA) cross-linked by a ROS-responsive linker. The obtained hydrogel could act as an effective ROS-scavenging agent to promote the wound closure by decreasing the ROS level and up-regulating M2 phenotype macrophages around the wound. Importantly, such hydrogel formed in the wound could allow release of therapeutics, including mupirocin to kill bacteria, and granulocyte-macrophage colony-stimulating factor (GM-CSF) to accelerate the wound closure, in responsive to endogenous ROS existing in the wound microenvironment. Remarkably, our drug-loaded ROS-scavenging hydrogel could be employed to effectively treat various types of wounds including difficult-to-heal diabetic wounds with bacterial infection. Therefore, this work presents an effective strategy based on ROS-scavenging hydrogel for wound healing under various kinds of complications.
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Cites
Gao, F., Xu, Z., Liang, Q., Li, H., Peng, L., Wu, M., Zhao, X., Cui, X., Ruan, C., & Liu, W. (2019) · Advanced Science · doi:10.1002/advs.201900867 · Cited by 365
Wu, H., Li, F., Shao, W., Gao, J., & Ling, D. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00850 · Cited by 338
Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response
Grice, E. A., Snitkin, E. S., Yockey, L. J., Bermudez, D. M., Program, N. C. S., Liechty, K. W., Segre, J. A., Mullikin, J., Blakesley, R., Young, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004204107 · Cited by 227
Cited by
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Macrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Faridi-Majidi, R., De Smedt, S. C., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 573
Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations
Zeng, Q., Qi, X., Shi, G., Zhang, M., & Haick, H. (2022) · ACS Nano · doi:10.1021/acsnano.1c08411 · Cited by 532
Anti‐inflammatory hydrogel dressings and skin wound healing
Huang, C., Dong, L., Zhao, B., Lu, Y., Huang, S., Yuan, Z., Luo, G., Xu, Y., & Qian, W. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1094 · Cited by 445
Self-citationTissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
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Metadata
- Authors
- Zhao, H., Huang, J., Li, Y., Lv, X., Zhou, H., Wang, H., Xu, Y., Wang, C., Wang, J., & Liu, Z.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 258
- Pages
- 120286
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3047317117
- Cited by
- 841
- References
- 3
- FWCI
- 38.87
- Type
- journal article
- Language
- en
- Open access
- closed
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