State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery

Cited by (330)

Items 101–200 of 330

  1. New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery
    Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, Alexandru Mihai Grumezescu · 2021 · Pharmaceutics
  2. Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles
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  4. Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer
    Junyi Zhang, Kamran Ali, Jianwei Wang · 2024 · International Journal of Nanomedicine
  5. In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA
    Ayoub Medjmedj, Albert Ngalle Loth, Rudy Clémençon, Josef Hamáček, Chantal Pichon, Federico Perche · 2022 · Nanomaterials
  6. Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out
    Anindita De, Young Tag Ko · 2023 · Expert Opinion on Drug Delivery
  7. Microfluidic ultrasonic cavitation enables versatile and scalable synthesis of monodisperse nanoparticles for biomedical application
    Zhikai Liu, Mei Yang, Yao Wang, Tingting Wang, Guangwen Chen · 2023 · Chemical Engineering Science
  8. Overview on LNP-mRNA encapsulation unit operation: Mixing technologies, scalability, and influence of formulation & process parameters on physico-chemical characteristics
    Laurine Hourdel, Noureddine Lebaz, Florent Peral, Manon Ripoll, Stéphanie Briançon, Fethi Bensaid, Sumit Luthra, Claudia Cogné · 2025 · International Journal of Pharmaceutics
  9. Engineered nanotransporters for efficient RNAi delivery in plant protection applications
    Yue Xing, Hao Jiang, Lin Cai · 2025 · Journal of Integrative Plant Biology
  10. Advances in buccal and oral delivery of insulin
    Amani Elsayed, Mayyas M. Al-Remawi, Nisrein Jaber, Khalid M. Abu–Salah · 2023 · International Journal of Pharmaceutics
  11. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics
    Ada W.Y. Leung, Carolyn Amador, Linchuan Wang, Urmi Vijay Mody, Marcel B. Bally · 2019 · Pharmaceutics
  12. Process development of tangential flow filtration and sterile filtration for manufacturing of mRNA-lipid nanoparticles: A study on membrane performance and filtration modeling
    Wenjun Wu, Líliam Teixeira Oliveira, A. Jain, Yury Karpov, Kirstin Olsen, Yu Wu, Rajesh Krishnan Gopalakrishna Panicker · 2025 · International Journal of Pharmaceutics
  13. Engineering Lipid Nanoparticles for mRNA Immunotherapy
    Robby C. Zwolsman, Youssef Bahaaeldin Darwish, Ewelina Kluza, Roy van der Meel · 2025 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  14. Elucidating lipid nanoparticle properties and structure through biophysical analyses
    Marshall Scott Padilla, Sarah J. Shepherd, Andrew R. Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A. Joseph, Hannah M. Yamagata, Adele S. Ricciardi et al. · 2025 · Nature Biotechnology
  15. Endocytosis-like DNA uptake by cell wall-deficient bacteria
    Renée Kapteijn, Shraddha Shitut, Dennis Aschmann, Le Zhang, Marit A. de Beer, Deniz Daviran, Rona Roverts, Anat Akiva, Gilles P. van Wezel, Alexander Kros et al. · 2022 · Nature Communications
  16. Complex Structures Made Simple – Continuous Flow Production of Core Cross‐Linked Polymeric Micelles for Paclitaxel Pro‐Drug‐Delivery
    Tobias Alexander Bauer, Jonas Schramm, Federico Fenaroli, Svenja Siemer, Christine Ilona Seidl, Christine Rosenauer, Regina Bleul, Roland H. Stauber, Kaloian Koynov, Michael Maskos et al. · 2023 · Advanced Materials
  17. Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy
    Zheng‐Rong Lu, Victoria E. A. Laney, Ryan C.W. Hall, Nadia R. Ayat · 2020 · Advanced Healthcare Materials
  18. Nanomedicine for Gene Delivery and Drug Repurposing in the Treatment of Muscular Dystrophies
    Ilaria Andreana, Mathieu Repellin, Flavia Carton, David Kryza, Stéphanie Briançon, Bénédicte Chazaud, Rémi Mounier, Silvia Arpicco, Manuela Malatesta, Barbara Stella et al. · 2021 · Pharmaceutics
  19. Formulation of Nucleic Acids by Encapsulation in Lipid Nanoparticles for Continuous Production of mRNA
    Alina Hengelbrock, A. Schmidt, Jochen Strube · 2023 · Processes
  20. Field-flow fractionation - an excellent tool for fractionation, isolation and/or purification of biomacromolecules
    Susanne Κ. Wiedmer, Marja‐Liisa Riekkola · 2023 · Journal of Chromatography A
  21. Nanomaterials for targeted therapy of kidney diseases: Strategies and advances
    Zhiwen Wang, Chun Zhang · 2025 · Materials Today Bio
  22. Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
    Xiaodong Yu, Chenyuan Huang, Martijn J.W. Evers, Jingjing Liu, Hui Jun Ting, Sitong Zhang, Suet Yen Chong, Michelle Siying Tan, Siyu Wang, Nilofer Sayed et al. · 2025 · Science Advances
  23. Genetically Engineered Biomimetic Nanoparticles for Targeted Delivery of mRNA to Treat Rheumatoid Arthritis
    Jianhai Chen, Jianwei Tan, Jian Li, Wenxiang Cheng, Liqing Ke, Anqiao Wang, Qinglin Wang, Sien Lin, Gang Li, Benguo Wang et al. · 2023 · Small Methods
  24. One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery
    Niko Kimura, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi · 2021 · ACS Applied Bio Materials
  25. Lipid Vesicles and Other Polymolecular Aggregates—From Basic Studies of Polar Lipids to Innovative Applications
    Peter Walde, Sosaku Ichikawa · 2021 · Applied Sciences
  26. Zwitterionic Polymer-Decorated Lipid Nanoparticles for mRNA Delivery in Mammalian Cells
    Phim-on Khunsuk, Chitsuda Pongma, Tanapat Palaga, Voravee P. Hoven · 2023 · Biomacromolecules
  27. Dialysis is a key factor modulating interactions between critical process parameters during the microfluidic preparation of lipid nanoparticles
    Ronny Vargas, Miquel Romero-Obón, Tomás Berasategui, David A. Narváez-Narváez, Patricia Ramirez, Anna Nardi-Ricart, Encarna García‐Montoya, Pilar Pérez‐Lozano, Josep Maria Suñé-Negre, Cristina Moreno‐Castro et al. · 2023 · Colloids and Interface Science Communications
  28. Microfluidic preparation of various perfluorocarbon nanodroplets: Characterization and determination of acoustic droplet vaporization (ADV) threshold
    Romain Melich, Philippe Bussat, Luca Morici, Alexis Vivien, Emmanuel Gaud, Thierry Bettinger, Samir Cherkaoui · 2020 · International Journal of Pharmaceutics
  29. On-chip controlled synthesis of polycaprolactone nanoparticles using continuous-flow microfluidic devices
    Fazlollah Heshmatnezhad, Ali Reza Solaimany Nazar · 2020 · Journal of Flow Chemistry
  30. mRNA-based therapeutic strategies for cancer treatment
    Thilelli Taibi, Sehyun Cheon, Fabiana Perna, Ly Vu · 2024 · Molecular Therapy
  31. Taylor Dispersion Analysis to support lipid-nanoparticle formulations for mRNA vaccines
    Camille Malburet, Laurent Leclercq, Jean‐François Cotte, Jérôme Thiebaud, Emilie Bazin, Marie Garinot, Hervé Cottet · 2022 · Gene Therapy
  32. Microfluidics for Formulation and Scale-Up Production of Nanoparticles for Biopharma Industry
    Mingzhi Yu, Allen Mathew, Dongsheng Liu, Yixin Chen, Jing Wu, Yuguo Zhang, Nan Zhang · 2024 · AAPS introductions in the pharmaceutical sciences
  33. Controlled preparation of lipid nanoparticles in microreactors: Mixing time, morphology and mRNA delivery
    Daixin Chen, Zhikai Liu, Letao Guo, Lixia Yang, Yu-Chao Zhao, Mei Yang · 2025 · Chemical Engineering Journal
  34. Design principles of lipid nanoparticles for RNA delivery
    Mariah Lynn Arral, Kathryn A. Whitehead · 2026 · Nature Reviews Bioengineering
  35. Strategies to deliver RNA by nanoparticles for therapeutic potential
    Alysia Cox, Siyoung A. Lim, Eun Ji Chung · 2021 · Molecular Aspects of Medicine
  36. Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
    Zuzana Hejdankova, Václav Vaněk, František Sedlák, Jan Procházka, Audrey Diederichs, Sami Kereı̈che, Barbora Novotná, Miloš Buděšı́nský, Gabriel Birkuš, Klára Grantz Šašková et al. · 2021 · Advanced Functional Materials
  37. Ionizable drug delivery systems for efficient and selective gene therapy
    Yuqi Zhang, Ranran Guo, Yonghu Chen, Tian‐Cheng Li, Wen-Zhen Du, Rongwu Xiang, Jibin Guan, Yupeng Li, Yuanyu Huang, Zhiqiang Yu et al. · 2023 · Military Medical Research
  38. Flash nanoprecipitation assisted self-assembly of ionizable lipid nanoparticles for nucleic acid delivery
    Bishal Misra, Krystal A. Hughes, William H. Pentz, Parinya Samart, Werner J. Geldenhuys, Sharan Kumar Reddy Bobbala · 2024 · Nanoscale
  39. Mesoscopic Structure of Lipid Nanoparticle Formulations for mRNA Drug Delivery: Comirnaty and Drug-Free Dispersions
    Tobias Unruh, Klaus Götz, Carola S. Vogel, Erik Fröhlich, Andreas Scheurer, Lionel Porcar, Frank Steiniger · 2024 · ACS Nano
  40. Light-Triggered Cellular Delivery of Oligonucleotides
    Leena-Stiina Kontturi, Joep B. van den Dikkenberg, Arto O. Urtti, Wim E. Hennink, Enrico Mastrobattista · 2019 · Pharmaceutics
  41. Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery
    Shahd Qassem, Dor Breier, Gonna Somu Naidu, Inbal Hazan‐Halevy, Dan Peer · 2024 · Molecular Therapy — Nucleic Acids
  42. A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement
    Anindita De, Young Tag Ko · 2022 · Expert Opinion on Drug Delivery
  43. Microfluidics for Nanomedicine Delivery
    Kangfu Chen, Hongfen Yang, Ren Cai · 2025 · ACS Biomaterials Science & Engineering
  44. A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs
    Hiroki Tanaka, Yuka Sato, Tomoya Nakabayashi, Akira Tanaka, Kazuma Nishio, Chika Matsumoto, Atsuya Matsumaru, Takuma Yamakawa, Kota Ishizaki, Keisuke Ueda et al. · 2025 · Nano Letters
  45. Meeting vaccine formulation challenges in an emergency setting: Towards the development of accessible vaccines
    Allegra Peletta, Céline Lemoine, Thomas Courant, Nicolas Collin, Gerrit Borchard · 2023 · Pharmacological Research
  46. Synthesizing Lipid Nanoparticles by Turbulent Flow in Confined Impinging Jet Mixers
    Sai Nikhil Subraveti, Brian K. Wilson, Navid Bizmark, Jason X. Liu, Robert K. Prud’homme · 2024 · Journal of Visualized Experiments
  47. Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
    Christina M. Bailey‐Hytholt, Paroma Ghosh, Julia Dugas, Isidro E. Zarraga, Amey Bandekar · 2021 · Journal of Visualized Experiments
  48. Lipid‐based nucleic acid therapeutics with in vivo efficacy
    Md Abu Sufian, Marc Antoniu Ilies · 2022 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  49. Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models – a comprehensive review
    Yusuf M. Idres, Adi Idris, Wenqing Gao · 2025 · Drug Delivery and Translational Research
  50. RNA nanomedicine in liver diseases
    Anita K. Bakrania, Yulin Mo, Gang Zheng, Mamatha Bhat · 2023 · Hepatology
  51. Soybean Oil‐Derived Lipids for Efficient mRNA Delivery
    Zhongmin Tang, Fan Yu, Jessica C. Hsu, Jianlin Shi, Weibo Cai · 2023 · Advanced Materials
  52. Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers
    Gi-Su Na, Jeong‐Un Joo, Joo Young Lee, Yejin Yun, Byung Kwon Kaang, Joo-Sung Yang, Kyungjin Kim, Dong-Pyo Kim · 2024 · Journal of Controlled Release
  53. Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy
    Zhangkun Liu, Shengkai Li, Xin Xia, Zhaotian Zhu, Long Chen, Zhuo Chen · 2019 · Small Methods
  54. coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid–Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications
    Felicia Roffo, Alfonso Maria Ponsiglione, Paolo A. Netti, Enza Torino · 2022 · Biomedicines
  55. Lipid nanoparticle steric stabilization roadmap
    Xudong Cai, Jiali Zhai, Nhiem L. Tran, Xavier Mulet, Calum John Drummond · 2022 · Advances in biomembranes and lipid self-assembly
  56. Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets
    Purva Khare, Sara X. Edgecomb, Christine M. Hamadani, James F. Conway, Eden E. L. Tanner, Devika Soundara Manickam · 2023 · Nanoscale Advances
  57. Research progress and application exploration of typical microreactor technologies for health monitoring and disease Diagnosis/Treatment
    Zhongjian Tan, Yun Hong Zheng, Huanhuan Shi, Weizheng Xu, Xuanhao Jia, Zhengxian Dan, Jiacong Liao, Zhiying Dai, Chenyang Xu · 2024 · Chemical Engineering Journal
  58. High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline
    Lois Lam, Stephanie Louise Watson, Yogambha Ramaswamy, Gurvinder Singh · 2025 · Advanced Science
  59. Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter
    Neil Welling Taylor, Wanli Ma, Adam Kristopeit, Sheng‐Ching Wang, Andrew L. Zydney · 2022 · Journal of Membrane Science
  60. Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study
    Anthony Cunha, Alexandra Gaubert, Julien Verget, Marie-Laure Thiolat, Philippe Barthélémy, Laurent Latxague, Benjamin Dehay · 2022 · Pharmaceutics
  61. Ionizable Drugs Enable Intracellular Delivery of Co‐Formulated siRNA
    Kai V. Slaughter, Eric N. Donders, Michael S. Jones, Sami G. Sabbah, Mitchell J. Elliott, Brian K. Shoichet, David W. Cescon, Molly Sandra Shoichet · 2024 · Advanced Materials
  62. NANOSPRESSO: toward personalized, locally produced nucleic acid nanomedicines
    Mariona Estapé Sentí, Alexandre Ceccaldi, Marta Luciani, Nadine Saber, Paul J. L. Schürmann, Maurits W. Geerlings, Peter Hölig, Joel de Beer, Michael Hannus, Fred Campbell et al. · 2025 · Frontiers in Science
  63. Scalable Production of Lipid Nanoparticles Containing Amphotericin B
    Jayesh A. Kulkarni, Sam Chen, Yuen Yi C. Tam · 2021 · Langmuir
  64. Time-dependent particle size increase during lipid nanoparticle purification by cross-flow filtration
    Annabelle Dietrich, Nicole Beckert, Jürgen J. Hubbuch · 2025 · Journal of Colloid and Interface Science
  65. Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics
    Pavan Inguva, Saikat Mukherjee, Pierre J. Walker, Vico Tenberg, Cedric Devos, Sunkyu Shin, Yanchen Wu, Srimanta Santra, Jie Wang, Shalini Singh et al. · 2025 · Biotechnology Advances
  66. Replacing poly(ethylene glycol) with RAFT lipopolymers in mRNA lipid nanoparticle systems for effective gene delivery
    Dayangku Nordiyana B P Hassanel, Emily H. Pilkington, Yi Ju, Stephen John Kent, Colin William Pouton, Nghia Phuoc Truong · 2024 · International Journal of Pharmaceutics
  67. Nano Plasma Membrane Vesicle‐Lipid Nanoparticle Hybrids for Enhanced Gene Delivery and Expression
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  68. Corosolic acid derivative-based lipid nanoparticles for efficient RNA delivery
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  69. The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens
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  70. Intracellular trafficking of lipid nanoparticles is hindered by cholesterol
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  71. Single particle charge detection mass spectrometry enables molecular characterization of lipid nanoparticles and mRNA packaging
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  72. mRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeutics
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  73. Industrial Perspective on the Manufacturing of Lipid Nanoparticles for Nucleic Acid Delivery
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  74. Golden Threads of Lipid Nanoparticles (LNPs) contributing to COVID-19 mRNA Vaccine: A Review
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  75. Lipid-Based Colloidal Nanocarriers for Site-Specific Drug Delivery
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  76. Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy
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  77. Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control
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  78. RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems
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  79. Single pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics
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  80. An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single dose
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  82. Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated
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  83. Computational approaches to lipid-based nucleic acid delivery systems
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