Cullis, Pieter R.

Liposomal drug delivery systems: From concept to clinical applications

Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews

Nanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Cited by 4,839

Drug Delivery Systems: Entering the Mainstream

Allen, T. M., & Cullis, P. R. (2004) · Science

Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Cited by 4,552

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,822

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., et al. (2019) · Nature Nanotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,636

The current landscape of nucleic acid therapeutics

Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R., & van der Meel, R. (2021) · Nature Nanotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,371

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie International Edition

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,267

Lipid Nanoparticle Systems for Enabling Gene Therapies

Cullis, P. R., & Hope, M. J. (2017) · Molecular Therapy

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,208

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., et al. (2012) · Molecular Therapy - Nucleic Acids

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 685

On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA

Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., van der Meel, R., Thewalt, J. L., Tam, Y. Y. C., & Cullis, P. R. (2018) · ACS Nano

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 663

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., et al. (2013) · Molecular Therapy

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 625

Lipid nanoparticles enabling gene therapies: from concepts to clinical utility

Kulkarni, J. A., Cullis, P. R., & van der Meel, R. (2018) · Nucleic Acid Therapeutics

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 592

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., et al. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 454

Lipid nanoparticle technology for therapeutic gene regulation in the liver

Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 376

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016) · Journal of Controlled Release

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 366

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Leung, A. K. K., Tam, Y. Y. C., Chen, S., Hafez, I. M., & Cullis, P. R. (2015) · The Journal of Physical Chemistry B

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 359

Developments in liposomal drug delivery systems

Maurer, N., Fenske, D. B., & Cullis, P. R. (2001) · Expert Opinion on Biological Therapy

Nanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Cited by 344

State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods

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Cited by 332

Advances in lipid nanoparticles for siRNA delivery

Tam, Y., Chen, S., & Cullis, P. (2013) · Pharmaceutics

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 229

Poly(ethylene glycol)−Lipid Conjugates Regulate the Calcium-Induced Fusion of Liposomes Composed of Phosphatidylethanolamine and Phosphatidylserine

Holland, J. W., Hui, C., Cullis, P. R., & Madden, T. D. (1996) · Biochemistry

Lipid Membrane Structure and BehaviorNanoparticle-Based Drug Delivery

Cited by 223

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Pattipeiluhu, R., Arias‐Alpizar, G., Basha, G., Chan, K. Y. T., Bussmann, J., Sharp, T. H., Moradi, M., Sommerdijk, N., Harris, E. N., Cullis, P. R., et al. (2022) · Advanced Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 194

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Rungta, R. L., Choi, H. B., Lin, P. J., Ko, R. W., Ashby, D., Nair, J., Manoharan, M., Cullis, P. R., & MacVicar, B. A. (2013) · Molecular Therapy—Nucleic Acids

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 165

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C., & Cullis, P. R. (2019) · Nanoscale

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 161

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

Chen, S., Tam, Y. Y. C., Lin, P. J. C., Leung, A. K. K., Tam, Y. K., & Cullis, P. R. (2014) · Journal of Controlled Release

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 160

Lipid nanoparticles for short interfering RNA delivery

Leung, A. K. K., Tam, Y. Y. C., & Cullis, P. R. (2014) · Advances in genetics

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 158