The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Airway Epithelial Progenitors Are Region Specific and Show Differential Responses to Bleomycin-Induced Lung Injury
Open accessAbstract
Mechanisms that regulate regional epithelial cell diversity and pathologic remodeling in airways are poorly understood. We hypothesized that regional differences in cell composition and injury-related tissue remodeling result from the type and composition of local progenitors. We used surface markers and the spatial expression pattern of an SFTPC-GFP transgene to subset epithelial progenitors by airway region. Green fluorescent protein (GFP) expression ranged from undetectable to high in a proximal-to-distal gradient. GFPhi cells were subdivided by CD24 staining into alveolar (CD24neg) and conducting airway (CD24low) populations. This allowed for the segregation of three types of progenitors displaying distinct clonal behavior in vitro. GFPneg and GFPlow progenitors both yielded lumen containing colonies but displayed transcriptomes reflective of pseudostratified and distal conducting airways, respectively. CD24lowGFPhi progenitors were present in an overlapping distribution with GFPlow progenitors in distal airways, yet expressed lower levels of Sox2 and expanded in culture to yield undifferentiated self-renewing progeny. Colony-forming ability was reduced for each progenitor cell type after in vivo bleomycin exposure, but only CD24lowGFPhi progenitors showed robust expansion during tissue remodeling. These data reveal intrinsic differences in the properties of regional progenitors and suggest that their unique responses to tissue damage drive local tissue remodeling.
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Cites
Generation of a functional mammary gland from a single stem cell
Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005
Effective mucus clearance is essential for respiratory health
Randell, S. H., & Boucher, R. C. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0082sf · Cited by 335 · cited 1×
“Its expression has been localized to adult tissue stem cells found in a number of adult tissues including the stomach, cervix, anus, testes, lens, and multiple glands, where it fulfills important roles in adult tissue regeneration and stem cell maintenance [31].”
BackgroundSelf-citation
Cited by
Type 2 alveolar cells are stem cells in adult lung
Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776
Self-citationHogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., Niklason, L., Calle, E., Le, A., Randell, S. H., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.012 · Cited by 876
Self-citationLung organoids: current uses and future promise
Barkauskas, C. E., Chung, M.-I., Fioret, B., Gao, X., Katsura, H., & Hogan, B. L. M. (2017) · Development · doi:10.1242/dev.140103 · Cited by 444
Macrophages in Lung Injury, Repair, and Fibrosis
Cheng, P., Li, S., & Chen, H. (2021) · Cells · doi:10.3390/cells10020436 · Cited by 444
Self-citationLiang, J., Zhang, Y., Xie, T., Liu, N., Chen, H., Geng, Y., Kurkciyan, A., Mena, J. M., Stripp, B. R., Jiang, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4192 · Cited by 287
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Metadata
- Authors
- Chen, H., Matsumoto, K., Brockway, B. L., Rackley, C. R., Liang, J., Lee, J.-H., Jiang, D., Noble, P. W., Randell, S. H., Kim, C. F., & Stripp, B. R.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-20
- Volume
- 30
- Issue
- 9
- Pages
- 1948-1960
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2028871210
- Cited by
- 194
- References
- 2
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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