Effective mucus clearance is essential for respiratory health
Open accessAbstract
Studies of the pathogenesis of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), as well as novel genetic mouse models, vividly illustrate that effective "mucus clearance" is a critical innate airway defense mechanism.Modern physics, physical chemistry, biochemistry, and cell and systems biology are revealing the structure of the mucus clearance apparatus and elucidating key parameters underlying its efficient function.New paradigms are evolving to describe the interaction of the near-cell surface environment with overlying mucus, the dominant role of adequate hydration for effective mucus clearance, the role of nucleotide and nucleoside signaling to regulate airway surface hydration, the physiochemical basis of mucus adhesion, and the pathophysiologic consequences of impaired mucus clearance.The recent success of hypertonic saline to restore surface hydration and improve mucus clearance in CF suggests that novel therapeutic strategies will be similarly efficacious in other airway diseases, including chronic obstructive pulmonary disease (COPD).
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Low humidity in the respiratory tract leads to impaired mucociliary function and increases the risk of both upper and lower respiratory tract infections.
“Low humidity in the respiratory tract leads to impaired mucociliary function and increases the risk of both upper and lower respiratory tract infections [6].”
From Investigating the case of human nose shape and climate adaptation (2017) · cites this paper as [6]
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“…in asthma, COPD, sleep apnea of the obstructive type, atypical lung infections and cystic fibrosis (CF) where along with an acid reflux the coordination of breathing and swallowing (Miller et al. 2005) and clearance of microorganisms from the lower airways (Randell and Boucher 2006) are reduced.”
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“14 and 15).”
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- Authors
- Randell, S. H., & Boucher, R. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-01
- Volume
- 35
- Issue
- 1
- Pages
- 20-28
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- PMC
- PMC2658694
- OpenAlex
- W2104048715
- Cited by
- 335
- References
- 67
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 25 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 23 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 30 · 2013: 24 · 2012: 24
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- mucus clearance, cystic fibrosis, primary ciliary dyskinesia, mucus adhesion, nucleotide signaling, hypertonic saline, airway defense, chronic obstructive pulmonary disease
- MeSH terms
- Animals, Body Water, Humans, Inflammation, Mucociliary Clearance, Respiratory System, Immunity, Mucosal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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