The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines
Abstract
Hotair is a member of the recently described class of noncoding RNAs called lincRNA (large intergenic noncoding RNA). Various studies suggest that Hotair acts regulating epigenetic states by recruiting chromatin-modifying complexes to specific target sequences that ultimately leads to suppression of several genes. Although Hotair has been associated with metastasis and poor prognosis in different tumor types, a deep characterization of its functions in cancer is still needed. Here, we investigated the role of Hotair in the scenario of epithelial-to-mesenchymal transition (EMT) and in the arising and maintenance of cancer stem cells (CSCs). We found that treatment with TGF-β1 resulted in increased Hotair expression and triggered the EMT program. Interestingly, ablation of Hotair expression by siRNA prevented the EMT program stimulated by TGF-β1, and also the colony-forming capacity of colon and breast cancer cells. Furthermore, we observed that the colon CSC subpopulation (CD133+/CD44+) presents much higher levels of Hotair when compared with the non-stem cell subpopulation. These results indicate that Hotair acts as a key regulator that controls the multiple signaling mechanisms involved in EMT. Altogether, our data suggest that the role of Hotair in tumorigenesis occurs through EMT triggering and stemness acquisition. Stem Cells 2013;31:2827–2832
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Cites
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.013 · Cited by 399
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EMT, CTCs and CSCs in tumor relapse and drug-resistance
Mitra, A., Mishra, L., & Li, S. (2015) · Oncotarget · doi:10.18632/oncotarget.4037 · Cited by 465
Functions of lncRNA HOTAIR in lung cancer
Loewen, G., Jayawickramarajah, J., Zhuo, Y., & Shan, B. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0090-4 · Cited by 454
Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review
Cao, H., Xu, E., Liu, H., Wan, L., & Lai, M. (2015) · Pathology - Research and Practice · doi:10.1016/j.prp.2015.05.010 · Cited by 356
lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions
McCabe, E. M., & Rasmussen, T. P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.012 · Cited by 312
Ren, Y., Jia, H.-H., Xu, Y.-Q., Zhou, X., Zhao, X.-H., Wang, Y.-F., Song, X., Zhu, Z.-Y., Sun, T., Dou, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0758-4 · Cited by 217
Metadata
- Authors
- Pádua Alves, C., Fonseca, A. S., Muys, B. R., Barros e Lima Bueno, R., Bürger, M. C., Souza, J. E. S., Valente, V., Zago, M. A., & Silva, W. A.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-12-01
- Volume
- 31
- Issue
- 12
- Pages
- 2827-2832
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1622456909
- Cited by
- 218
- References
- 5
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
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